STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

Innate immune recognition

Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Pathologic Basis of Disease.

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STATs and Gene Regulation

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Innate Immunity: The Virtues of a Nonclonal System of Recognition

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Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

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JAKS AND STATS: Biological Implications

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Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

Ogura, Y., Inohara, N., Benito, A., Chen, F. F., Yamaoka, S., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008072200 · Cited by 1,357

Intracoronary Mesenchymal Stem Cells Promote Postischemic Myocardial Functional Recovery, Decrease Inflammation, and Reduce Apoptosis via a Signal Transducer and Activator of Transcription 3 Mechanism

Poynter, J. A., Herrmann, J. L., Manukyan, M. C., Wang, Y., Abarbanell, A. M., Weil, B. R., Brewster, B. D., & Meldrum, D. R. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2011.04.005 · Cited by 44

STAT3 Differentially Regulates TLR4-Mediated Inflammatory Responses in Early or Late Phases

Ahuja, A., Kim, E., Sung, G., & Cho, J. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207675 · Cited by 43

STAT3 Regulates Mouse Neural Progenitor Proliferation and Differentiation by Promoting Mitochondrial Metabolism

Su, Y., Zhang, W., Patro, C. P. K., Zhao, J., Mu, T., Ma, Z., Xu, J., Ban, K. H.-K., Yi, C., & Zhou, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00362 · Cited by 41

Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis

Bai, A., Hu, P., Chen, J., Song, X., Chen, W., Peng, W., Zeng, Z., & Gao, X. (2006) · International Journal of Colorectal Disease · doi:10.1007/s00384-006-0229-z · Cited by 41

Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice

Brandl, K., Tomisato, W., Li, X., Neppl, C., PIRIE, E. C., Falk, W., Xia, Y., Moresco, E. M. Y., Baccalà, R., Theofilopoulos, A. N., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210366109 · Cited by 39

Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma

Bu, L., Yu, G., Deng, W., Mao, L., Liu, J., Ma, S., Fan, T., Hall, B., Kulkarni, A. B., Zhang, W., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1130206 · Cited by 40

STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance

Barton, B. E. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.3.459 · Cited by 40

STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia

Bruserud, Ø., Nepstad, I., Hauge, M., Hatfield, K. J., & Reikvam, H. (2014) · Expert Review of Hematology · doi:10.1586/17474086.2015.971005 · Cited by 40

Controlling Gut Inflammation by Restoring Anti-Inflammatory Pathways in Inflammatory Bowel Disease

Giuffrida, P., Cococcia, S., Delliponti, M., Lenti, M. V., & Sabatino, A. D. (2019) · Cells · doi:10.3390/cells8050397 · Cited by 38

Stat3 in osteocytes mediates osteogenic response to loading

Corry, K. A., Zhou, H., Brustovetsky, T., Himes, E. R., Bivi, N., Horn, M. R., Kitase, Y., Wallace, J. M., Bellido, T., Brustovetsky, N., et al. (2019) · Bone Reports · doi:10.1016/j.bonr.2019.100218 · Cited by 37

Alternative Medicines as Emerging Therapies for Inflammatory Bowel Diseases

Singh, U. P., Singh, N. P., Busbee, P. B., Guan, H., Singh, B., Price, R. L., Taub, D. D., Mishra, M. K., Nagarkatti, M., & Nagarkatti, P. S. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2011.642909 · Cited by 40

Conditional Ablation of MHC-II Suggests an Indirect Role for MHC-II in Regulatory CD4 T Cell Maintenance

Shimoda, M., Mmanywa, F., Joshi, S. K., Li, T., Miyake, K., Pihkala, J. P. S., Abbas, J. A., & Koni, P. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6503 · Cited by 38

CCR1-Mediated STAT3 Tyrosine Phosphorylation and CXCL8 Expression in THP-1 Macrophage-like Cells Involve Pertussis Toxin-Insensitive Gα14/16 Signaling and IL-6 Release

Lee, M. M. K., Chui, R. K. S., Tam, I. Y. S., Lau, H. Y. A., & Wong, Y. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103359 · Cited by 38

Corilagin Attenuates Radiation-Induced Brain Injury in Mice

Tong, F., Zhang, J., Liu, L., Gao, X., Cai, Q., Wei, C., Dong, J.-H., Hu, Y., Wu, G., & Dong, X. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9591-6 · Cited by 37

JAK Inhibition: The Most Promising Agents in the IBD Pipeline?

Fernandez-Clotet, A., Castro‐Poceiro, J., & Panés, J. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190405141410 · Cited by 37

Inflammatory Angiogenesis and the Tumor Microenvironment as Targets for Cancer Therapy and Prevention

Bruno, A., Pagani, A., Magnani, E., Rossi, T., Noonan, D. M., Cantelmo, A. R., & Albini, A. (2013) · Cancer treatment and research · doi:10.1007/978-3-642-38007-5_23 · Cited by 37

Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients

Pang, Y. H., Zheng, C. Q., Yang, X. Z., & Zhang, W. J. (2007) · Cellular Immunology · doi:10.1016/j.cellimm.2007.10.003 · Cited by 38

Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion

Wang, M., Wang, Y., Abarbanell, A. M., Tan, J., Weil, B. R., Herrmann, J. L., & Meldrum, D. R. (2009) · Surgery · doi:10.1016/j.surg.2009.03.035 · Cited by 37

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

Martino, N., Ramos, R. B., Lu, S., Leyden, K., Tomaszek, L., Sadhu, S., Fredman, G., Jaitovich, A., Vincent, P. A., & Adam, A. P. (2021) · JCI Insight · doi:10.1172/jci.insight.147280 · Cited by 33

Cellular and Molecular Mechanisms of Tumor-Induced T-Cell Tolerance

Horna, P., & Sotomayor, E. M. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780006940 · Cited by 34

Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-κB activation in congenital heart disease

Gu, Q., Kong, Y., Yu, Z., Li, B., & Xiao, Y. (2011) · Biochimie · doi:10.1016/j.biochi.2011.02.009 · Cited by 36

STAT 3 promotes bone fracture healing by enhancing the FOXP 3 expression and the suppressive function of regulatory T cells

Sun, G., Wang, Z., Ti, Y., Wang, Y., Wang, J., Zhao, J., & Qian, H. (2017) · Apmis · doi:10.1111/apm.12706 · Cited by 35

MicroRNA124-IL6R Mediates the Effect of Nicotine in Inflammatory Bowel Disease by Shifting Th1/Th2 Balance Toward Th1

Qin, Z., Wang, P., Wan, J.-J., Zhang, Y., Wei, J., Sun, Y., & Liu, X. (2019) · Frontiers in Immunology · doi:10.2139/ssrn.3436242 · Cited by 36

STAT3 as a therapeutic target for Epstein-Barr virus (EBV) – associated nasopharyngeal carcinoma

Ho, Y., Tsao, S., Zeng, M., & Lui, V. W. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.052 · Cited by 36

STAT3 activation in macrophages following infection with Salmonella

Lin, T., & Bost, K. L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.039 · Cited by 33

Regulator of Calcineurin 1 Suppresses Inflammation during Respiratory Tract Infections

Junkins, R. D., MacNeil, A. J., Wu, Z., McCormick, C., & Lin, T. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203196 · Cited by 32

Stat3 loss in mesenchymal progenitors causes Job syndrome–like skeletal defects by reducing Wnt/β-catenin signaling

Yadav, P. S., Feng, S., Cong, Q., Kim, H., Liu, Y., & Yang, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020100118 · Cited by 34

B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors

Zhao, X., Zhang, Z., Moreira, D., Su, Y., Won, H., Adamus, T., Dong, Z., Liang, Y., Yin, H. H., Swiderski, P. M., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.007 · Cited by 32

Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells

Akla, N., Pratt, J., & Annabi, B. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.08.003 · Cited by 31

Mechanisms Underlying Bone Loss Associated with Gut Inflammation

Ke, K., Arra, M., & Abu‐Amer, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246323 · Cited by 31

Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFα- and NK cytotoxicity

Kulesza, D. W., Carré, T., Chouaı̈b, S., & Kaminska, B. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.005 · Cited by 31

Genomic and computational approaches to dissect the mechanisms of STAT3’s universal and cell type-specific functions

Hutchins, A. P., Diez, D., & Miranda-Saavedra, D. (2013) · JAK-STAT · doi:10.4161/jkst.25097 · Cited by 31

Peptide YY Attenuates STAT1 and STAT3 Activation Induced by TNF-α in Acinar Cell Line AR42J

Robinson, K., Vona-Davis, L. C., Riggs, D. R., Jackson, B., & McFadden, D. W. (2006) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2006.01.007 · Cited by 31

Gene expression in mononuclear cells from patients with inflammatory bowel disease

Mannick, E. E., Bonomolo, J. C., Horswell, R. L., Lentz, J. J., Serrano, M.-S., Zapata-Velandia, A. M., Gastañaduy, M., Himel, J. L., Rose, S. L., Udall, J. N., et al. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.03.014 · Cited by 30

The role of lnc-DC long non-coding RNA and SOCS1 in the regulation of STAT3 in coronary artery disease and type 2 diabetes mellitus

Alikhah, A., Kakhki, M. P., Ahmadi, A., Dehghanzad, R., Boroumand, M. A., & Behmanesh, M. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.12.001 · Cited by 29

Compartmentalized Response of IL-6/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development

Serrano, C., Galán, S., Rubio, J. F., Candelario‐Martínez, A., Montes-Gómez, A. E., Chánez-Paredes, S. D., Cedillo‐Barrón, L., Michael Schnoor, A., Meraz‐Ríos, M. A., Villegas‐Sepúlveda, N., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801060 · Cited by 29

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu, Y., Timani, K. A., Mantel, C., Fan, Y., Hangoc, G., Cooper, S. H., He, J. J., & Broxmeyer, H. E. (2011) · Blood · doi:10.1182/blood-2010-12-325332 · Cited by 29

The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice

Lee, Y. Y., Irfan, M., Quah, Y., Saba, E., Kim, S., Park, S., Jeong, M.-G., Kwak, Y.-S., & Rhee, M. H. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.02.004 · Cited by 28

Interleukins and STAT Signaling

Haque, S. J., & Sharma, P. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74007-9 · Cited by 28

Diversification of dendritic cell subsets

Li, H. S., & Watowich, S. S. (2013) · JAK-STAT · doi:10.4161/jkst.25112 · Cited by 26

Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis

Hoffman, J. M., Baritaki, S., Ruiz, J. J., Sideri, A., & Pothoulakis, C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.013 · Cited by 27

JAK selectivity: more precision less troubles

Roda, G., Buono, A. D., ARGOLLO, M. C., & Danese, S. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1780120 · Cited by 26

Signal transducer and activator of transcription 3–stimulated hypoxia inducible factor-1α mediates estrogen receptor-α–induced mesenchymal stem cell vascular endothelial growth factor production

Wang, M., Tan, J., Coffey, A. C., Fehrenbacher, J. W., Weil, B. R., & Meldrum, D. R. (2009) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2009.03.010 · Cited by 26

Animal models of intestinal inflammation: ineffective communication between coalition members

Lorenz, R. G., McCracken, V. J., & Elson, C. O. (2005) · Springer Seminars in Immunopathology · doi:10.1007/s00281-005-0208-4 · Cited by 26

Pleiotrophin (PTN) is expressed in vascularized human atherosclerotic plaques: IFN‐γ/JAK/STAT1 signaling is critical for the expression of PTN in macrophages

Li, F., Tian, F., Wang, L., Williamson, I., Sharifi, B. G., & Shah, P. K. (2009) · The FASEB Journal · doi:10.1096/fj.09-140780 · Cited by 26

BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation

Kanemaru, H., Yamane, F., Tanaka, H., Maeda, K., Satoh, T., & Akira, S. (2018) · International Immunology · doi:10.1093/intimm/dxy023 · Cited by 25

Immunologic Consequences of Signal Transducers and Activators of Transcription 3 Activation in Human Squamous Cell Carcinoma

Albesiano, E., Davis, M. B., See, A. P., Han, J. E., Lim, M. K., Pardoll, D. M., & Kim, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4058 · Cited by 25

Repurposing Antiestrogens for Tumor Immunotherapy

Welte, T., Zhang, X. H.-F., & Rosen, J. M. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1308 · Cited by 25

Visualisation of the T cell differentiation programme by Canonical Correspondence Analysis of transcriptomes

Ono, M., Tanaka, R. J., & Kano, M. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1028 · Cited by 24

Progress in Multiple Sclerosis Genetics

Goris, A., Pauwels, I., & Dubois, B. (2012) · Current Genomics · doi:10.2174/138920212803759695 · Cited by 25

Novel Synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Li, X., Ma, H.-G., Li, L., Chen, Y.-F., Sun, X., Dong, Z.-Z., Liu, J.-Y., Zhu, W.-M., & Zhang, J.-T. (2018) · Oncogene · doi:10.1038/s41388-017-0076-0 · Cited by 22

IL-22 Negatively Regulates Helicobacter pylori-Induced CCL20 Expression in Gastric Epithelial Cells

Chen, J.-P., Wu, M., Kuo, S., & Liao, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097350 · Cited by 24

Transcription factors in autoimmune diseases

Stanford, L. P. (2008) · Frontiers in bioscience · doi:10.2741/3001 · Cited by 24

Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs

Shrestha, A. K., Menon, R., El‐Saie, A., Barrios, R. J., Reynolds, C. L., & Shivanna, B. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00013.2020 · Cited by 25

Role of Endothelial STAT3 in Cerebrovascular Function and Protection from Ischemic Brain Injury

Davis, C. M., Lyon-Scott, K., Varlamov, E. V., Zhang, W. H., & Alkayed, N. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012167 · Cited by 23

Status of Stat3 in an Ovalbumin-Induced Mouse Model of Asthma: Analysis of the Role of Socs3 and IL-6

Paul, B., Mishra, V., Chaudhury, B., Awasthi, A., Das, A. B., Saxena, U., Saxena, A., Chauhan, L. K. S., Kumar, P., & Raisuddin, S. (2008) · International Archives of Allergy and Immunology · doi:10.1159/000155740 · Cited by 22

Tofacitinib for the treatment of ulcerative colitis

Izzo, R., Bevivino, G., & Monteleone, G. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1189900 · Cited by 22

STATs signaling pathways in dendritic cells: As potential therapeutic targets?

Sohrabi, S., Masoumi, J., Naseri, B., Ghorbaninezhad, F., Alipour, S., Kazemi, T., Heris, J. A., Maleki, L. A., Basirjafar, P., Zandvakili, R., et al. (2023) · International Reviews of Immunology · doi:10.1080/08830185.2023.2274576 · Cited by 21

Dendritic cell functions in vivo: A user's guide to current and next‐ generation mutant mouse models

Dalod, M., & Scheu, S. (2022) · European Journal of Immunology · doi:10.1002/eji.202149513 · Cited by 19

Role of STAT3 in regulatory T lymphocyte plasticity during acute graft-vs.-host-disease

Fujino, M., & Li, X. (2013) · JAK-STAT · doi:10.4161/jkst.24529 · Cited by 19

Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish

Bu, Y., Su, F., Wang, X., Gao, H. F., Lei, L., Chang, N., Wu, Q., Hu, K., Zhu, X., Chang, Z., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.145367 · Cited by 18

Signal transducer and activator of transcription 3 regulation by novel binding partners

Matsuda, T. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.324 · Cited by 19

Conditional overexpression of Stat3α in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern

Redell, M. S., Tsimelzon, A. I., Hilsenbeck, S. G., & Tweardy, D. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206766 · Cited by 20

SHORT COMMUNICATION: STAT3 Polymorphisms Linked with Idiopathic Recurrent Miscarriages

Finan, R. R., Mustafa, F. E., Al-Zaman, I., Madan, S., Issa, A. A., & Almawi, W. Y. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00765.x · Cited by 18

Multiple Cytotoxic Factors Involved in IL-21 Enhanced Antitumor Function of CIK Cells Signaled through STAT-3 and STAT5b Pathways

Rajbhandary, S., Zhao, M., Zhao, N., Lu, W., Zhu, H.-B., Xiao, X., Deng, Q., & Li, Y. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.10.5825 · Cited by 18

Leptin Signaling Is Not Required for Anorexigenic Estradiol Effects in Female Mice

Kim, J. S., Rizwan, M. Z., Clegg, D. J., & Anderson, G. M. (2016) · Endocrinology · doi:10.1210/en.2015-1594 · Cited by 18

Tumor-Induced Immune Suppression

Gabrilovich, D. I., & Hurwitz, A. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-69118-3 · Cited by 18

Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis

Zhang, H., Li, H. S., Hillmer, E. J., Zhao, Y., Chrisikos, T. T., Hu, H., Wu, X. Y., Thompson, E. J., Clise-Dwyer, K., Millerchip, K. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713889115 · Cited by 17

Myeloid cells require gp130 signaling for protective anti‐inflammatory functions during sepsis

Sackett, S. D., Otto, T., Mohs, A., Sander, L. E., Strauch, S., Streetz, K. L., Kroy, D. C., & Trautwein, C. (2019) · The FASEB Journal · doi:10.1096/fj.201802118r · Cited by 18

Transcription factors in the pathogenesis of autoimmunity

Peng, S. L. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.10.008 · Cited by 18

CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury

Huang, P. C., Huo, Y., Lou, X., Li, H., Barnstable, C. J., Zhang, C., & Zhang, S. S.-M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.015 · Cited by 17

A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia

Lemper, M., Groef, S. D., Stangé, G. M., Baeyens, L., & Heimberg, H. (2016) · Diabetologia · doi:10.1007/s00125-016-4023-3 · Cited by 17

Activated signal transducer and activator of transcription-3 (STAT3) is a poor regulator of tumour necrosis factor-α production by human monocytes

Prêle, C. M., Keith‐Magee, A. L., Murcha, M. W., & Hart, P. H. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03291.x · Cited by 16

Evidence That the Anti-Inflammatory Effect of Rubiadin-1-methyl Ether Has an Immunomodulatory Context

Mohr, E. T. B., Nascimento, M. V. P. D. S., da Rosa, J. S., Vieira, G. N., Kretzer, I. F., Sandjo, L. P., & Dalmarco, E. M. (2019) · Mediators of Inflammation · doi:10.1155/2019/6474168 · Cited by 17

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation

Wang, M., Zhang, W., Crisostomo, P. R., Markel, T. A., Meldrum, K. K., Fu, X. Y., & Meldrum, D. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00251.2007 · Cited by 17

Akkermansia muciniphila Protects Against Trinitrobenzene Sulfonic Acid Induced Colitis by Inhibiting IL6/STAT3 Pathway

Jiang, M., Jia, Y., Ma, C., Zeng, Z., Wu, Y., Gan, H., & Zhang, H. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf057 · Cited by 15

The genetics of hyper IgE syndromes

AlYafie, R. S., Velayutham, D., van Panhuys, N., & Jithesh, P. V. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1516068 · Cited by 16

The Straw That Stirs the Drink: Insight into the Pathogenesis of Inflammatory Bowel Disease Revealed Through the Study of Microflora-Induced Inflammation in Genetically Modified Mice

Horwitz, B. H. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20098 · Cited by 15

Natural product derived immune-regulatory agents

Talmadge, J. E. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.025 · Cited by 15

Expression of interleukin-24 and its receptor in human pancreatic myofibroblasts

Andoh, A. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.793 · Cited by 15

Nicotine induces TIPE2 upregulation and Stat3 phosphorylation contributes to cholinergic anti-inflammatory effect

Sui, H. X., Ke, S. Z., Xu, D., Lü, N., Wang, Y. N., Zhang, Y. H., & GAO, F. G. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4080 · Cited by 13

Antimicrobial peptide Isalo scorpion cytotoxic peptide (IsCT) enhanced growth performance and improved intestinal immune function associated with janus kinases (JAKs)/signal transducers and activators of transcription (STATs) signalling pathways in on-growing grass carp (Ctenopharyngodon idella)

Hu, Q.-Y., Wu, P., Feng, L., Jiang, W., Liu, Y., Kuang, S., Tang, L., Li, J., & Zhou, X. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736585 · Cited by 13

Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome

Daw, S., Chatterjee, R., Law, A., & Law, S. K. A. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.10.010 · Cited by 14

Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis

Zhou, L., Yan, Z., Yang, W., Buckley, J. A., Diffalha, S. A., Benveniste, E. N., & Qin, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1163987 · Cited by 15

YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α

Takeuchi, A., Shiota, M., Tatsugami, K., Yokomizo, A., Kuroiwa, K., Dejima, T., Tanaka, S., Itsumi, M., Eto, M., & Naito, S. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1356-8 · Cited by 13

Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk

Rohmah, R. N., Hardiyanti, F., & Fatchiyah, F. (2015) · Acta Informatica Medica · doi:10.5455/aim.2015.23.233-238 · Cited by 14

Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

Lee, D., Wang, Y., Kalaitzidis, D., Ramachandran, J., Eda, H., Sykes, D. B., Raje, N. S., & Scadden, D. T. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84620 · Cited by 13

Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3

Liu, Z., Liu, J., Wei, Y.-P., Li, J.-T., Zhang, J.-X., Yu, R., Yang, Q., Miao, Y.-L., & Dong, W.-G. (2025) · Cell Death and Disease · doi:10.1038/s41419-024-07315-z · Cited by 13

IL-10 Inhibits LPS-Induced Expression of miR-147 in Murine Macrophages

Cardwell, L. N., & Weaver, B. K. (2014) · Advances in Biological Chemistry · doi:10.4236/abc.2014.44032 · Cited by 12

Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis

Kakhki, M. P., Rakhshi, N., Aleagha, M. S. E., Abdari, M., Alikhah, A., Safarian, G., Behmanesh, M., & Nikravesh, A. (2019) · Neurological Sciences · doi:10.1007/s10072-019-04092-y · Cited by 12

The STAT4 and STAT6 Pathways in Pancreatitis-Associated Lung Injury

Simovic, M. O., Ballard, B. R., Gray, K. D., & Stain, S. C. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.032 · Cited by 11

The role of STAT3 in antigen-IgG inducing regulatory CD4+Foxp3+T cells

Wang, R., Han, G., Wang, J., Song, L., Chen, G., Xu, R., Yu, M., Qian, J., Shen, B., & Li, Y. (2007) · Cellular Immunology · doi:10.1016/j.cellimm.2007.07.001 · Cited by 11

Inflammatory bowel disease: recent advances on genetics and innate immunity.

Karantanos, T., & Gazouli, M. (2011) · Europe PMC (PubMed Central) · Cited by 11

Increasing JAK/STAT Signaling Function of Infant CD4+ T Cells during the First Year of Life

Pena-Ponce, M. G. D., Rodriguez-Nieves, J., Bernhardt, J., Tuck, R. H., Choudhary, N. R., Mengual, M., Mollan, K. R., Hudgens, M. G., Peter-Wohl, S., & Paris, K. D. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00015 · Cited by 11

Expression of Stat3 and indoleamine 2, 3-dioxygenase in cornea keratocytes as factor of ocular immune privilege

Yang, J. W., Ham, D. S., Kim, H. W., Lee, S. G., Park, S. K., & Seo, S. K. (2011) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-011-1768-8 · Cited by 10

A STAT Need for Human Immunologic Studies to Understand Inflammatory Bowel Disease

Plevy, S. E. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41382.x · Cited by 10

Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements

Millrine, D., Figueras, A. C., Fernandez, J. U., Andrews, R., Szomolay, B., Cossins, B. C., Rice, C. M., Li, J., Tyrrell, V. J., McLeod, L., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300114 · Cited by 9

Applying Bioinformatic Platforms, In Vitro, and In Vivo Functional Assays in the Characterization of Genetic Variants in the GH/IGF Pathway Affecting Growth and Development

Domené, S., Scaglia, P. A., Gutiérrez, M., & Domené, H. M. (2021) · Cells · doi:10.3390/cells10082063 · Cited by 9

A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing

Sun, X., Chalmers, L., Fu, X., & Zhao, M. (2012) · Advances in Wound Care · doi:10.1089/wound.2011.0334 · Cited by 9

Impairment of Macrophage Functions is Associated with an Early Onset Intestinal Inflammation

Carroll, M. A., Yang, C., Lou, L. X., Poritz, L. S., & Zhang, S. S.-M. (2013) · DigitalCommons@UTEP (The University of Texas at El Paso)

STAT3-Deficiency in Bone Marrow Hematopoietic Stem Cells results in Dysfunctional Macrophages and Correlates with Crohn's Disease-like Pathogenesis

Carroll, M. A. (2010)

Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid‐specific signal transducer and activator of transcription 3‐deficient mice

Reindl, W., Weiß, S., Lehr, H., & Förster, I. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02473.x · Cited by 31

STAT3 in immune responses and inflammatory bowel diseases

Fu, X. Y. (2006) · Cell Research · doi:10.1038/sj.cr.7310029 · Cited by 90

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

Lovato, P., Brender, C., Agnholt, J. S., Kelsen, J., Kaltoft, K., Svejgaard, A., Eriksen, K. W., Woetmann, A., & Ødum, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207999200 · Cited by 199