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Cited by 358

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Functional and evolutionary genomics of Mycobacterium tuberculosis : Insights from genomic deletions in 100 strains

Open access
Tsolaki, Anthony G., Hirsh, Aaron E., DeRiemer, Kathryn, Enciso, Jose Antonio, Wong, Melissa Z., Hannan, Margaret, de la Salmoniere, Yves-Olivier L. Goguet, Aman, Kumiko, Kato-Maeda, Midori, Small, Peter M.·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0305634101
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Abstract

To better understand genome function and evolution in Mycobacterium tuberculosis , the genomes of 100 epidemiologically well characterized clinical isolates were interrogated by DNA microarrays and sequencing. We identified 68 different large-sequence polymorphisms (comprising 186,137 bp, or 4.2% of the genome) that are present in H37Rv, but absent from one or more clinical isolates. A total of 224 genes (5.5%), including genes in all major functional categories, were found to be partially or completely deleted. Deletions are not distributed randomly throughout the genome but instead tend to be aggregated. The distinct deletions in some aggregations appear in closely related isolates, suggesting a genomically disruptive process specific to an individual mycobacterial lineage. Other genomic aggregations include distinct deletions that appear in phylogenetically unrelated isolates, suggesting that a genomic region is vulnerable throughout the species. Although the deletions identified here are evidently inessential to the causation of disease (they are found in active clinical cases), their frequency spectrum suggests that most are weakly deleterious to the pathogen. For some deletions, short-term evolutionary pressure due to the host immune system or antibiotics may favor the elimination of genes, whereas longer-term physiological requirements maintain the genes in the population.

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Metadata

Authors
Tsolaki, A. G., Hirsh, A. E., DeRiemer, K., Enciso, J. A., Wong, M. Z., Hannan, M., de la Salmoniere, Y.-O. L. G., Aman, K., Kato-Maeda, M., & Small, P. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-03-15
Volume
101
Issue
14
Pages
4865-4870
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0305634101
OpenAlex
W2005203688
Cited by
358
References
31
FWCI
20.97
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Functional and evolutionary genomics of Mycobacterium tuberculosis : Insights from genomic deletions in 100 strains. https://app.cochat.ai/papers/10.1073/pnas.0305634101
The paper
Tsolaki, A. G., Hirsh, A. E., DeRiemer, K., Enciso, J. A., Wong, M. Z., Hannan, M., de la Salmoniere, Y.-O. L. G., Aman, K., Kato-Maeda, M., & Small, P. M. (2004). Functional and evolutionary genomics of Mycobacterium tuberculosis : Insights from genomic deletions in 100 strains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0305634101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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