The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray
Abstract
Bacille Calmette-Guérin (BCG) vaccines are live attenuated strains of Mycobacterium bovis administered to prevent tuberculosis. To better understand the differences between M. tuberculosis , M. bovis , and the various BCG daughter strains, their genomic compositions were studied by performing comparative hybridization experiments on a DNA microarray. Regions deleted from BCG vaccines relative to the virulent M. tuberculosis H37Rv reference strain were confirmed by sequencing across the missing segment of the H37Rv genome. Eleven regions (encompassing 91 open reading frames) of H37Rv were found that were absent from one or more virulent strains of M. bovis . Five additional regions representing 38 open reading frames were present in M. bovis but absent from some or all BCG strains; this is evidence for the ongoing evolution of BCG strains since their original derivation. A precise understanding of the genetic differences between closely related Mycobacteria suggests rational approaches to the design of improved diagnostics and vaccines.
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Cites
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Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
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Cited by
Pai, M., Behr, M. A., Dowdy, D., Dheda, K., Divangahi, M., Boehme, C. C., Ginsberg, A., Swaminathan, S., Spigelman, M., Getahun, H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.76 · Cited by 1,270
Self-citationMycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
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Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells
van der Wel, N., Hava, D., Houben, D., Fluitsma, D., van Zon, M., Pierson, J., Brenner, M., & Peters, P. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.059 · Cited by 960
Specific immune-based diagnosis of tuberculosis
Andersen, P., Munk, M., Pollock, J., & Doherty, T. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02742-2 · Cited by 924
Metadata
- Authors
- Behr, M. A., Wilson, M. A., Gill, W. P., Salamon, H., Schoolnik, G. K., Rane, S., & Small, P. M.
- Venue
- Science
- Published
- 1999-05-28
- Volume
- 284
- Issue
- 5419
- Pages
- 1520-1523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024974612
- Cited by
- 1,542
- References
- 12
- FWCI
- 59.87
- Type
- journal article
- Language
- en
- Open access
- closed
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