The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
Open accessAbstract
The hippocampal formation contains a distinct population of neurons organized into separate anatomical subregions. Each hippocampal subregion expresses a unique molecular profile accounting for their differential vulnerability to mechanisms of memory dysfunction. Nevertheless, it remains unclear which hippocampal subregion is most sensitive to the effects of advancing age. Here we investigate this question by using separate imaging techniques, each assessing different correlates of neuronal function. First, we used MRI to map cerebral blood volume, an established correlate of basal metabolism, in the hippocampal subregions of young and old rhesus monkeys. Second, we used in situ hybridization to map Arc expression in the hippocampal subregions of young and old rats. Arc is an immediate early gene that is activated in a behavior-dependent manner and is correlated with spike activity. Results show that the dentate gyrus is the hippocampal subregion most sensitive to the effects of advancing age, which together with prior studies establishes a cross-species consensus. This pattern isolates the locus of age-related hippocampal dysfunction and differentiates normal aging from Alzheimer's disease.
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Cites
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
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Self-citationEvolution of the neuropathology of Alzheimer's disease
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Imaging hippocampal function across the human life span: Is memory decline normal or not?
Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y. (2002) · Annals of Neurology · doi:10.1002/ana.10105 · Cited by 205
Self-citationWenz, F., Rempp, K., Brix, G., Knopp, M. V., Gückel, F., Heß, T., & van Kaick, G. (1996) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(95)02058-2 · Cited by 57
Cited by
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567
Memory and Executive Function in Aging and AD
Buckner, R. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.006 · Cited by 1,508
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353
Self-citationAdult Neurogenesis in the Hippocampus: From Stem Cells to Behavior
Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122
Metadata
- Authors
- Small, S. A., Chawla, M. K., Buonocore, M., Rapp, P. R., & Barnes, C. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-26
- Volume
- 101
- Issue
- 18
- Pages
- 7181-7186
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2140474748
- Cited by
- 280
- References
- 6
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Small, S. A., Chawla, M. K., Buonocore, M., Rapp, P. R., & Barnes, C. A. (2004). Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0400285101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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