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Cdx2 is essential for axial elongation in mouse development
Open accessAbstract
Inactivation of Cdx2 leads to preimplantation embryonic lethality. Rescue of the implantation defect by tetraploid fusion established that Cdx2 is necessary for trophoblastic development, vasculogenesis in the yolk sac mesoderm, allantoic growth, and chorioallantoic fusion. “Rescued” Cdx2 mutants die at late gastrulation stages because of failure of placental development. Cdx2 is also needed for the completion of the normal process of gastrulation and tail bud elongation. Presegmental paraxial mesoderm is severely restricted in amount and somites posterior to somite 5 are abnormal. The Cdx2 mutation, like mutations impairing Wnt and Fgf signaling, causes posterior truncations and disturbs axial patterning of the embryonic structures, indicated by changes in the Hox expression domains. The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning.
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Citations
Cited by
Strumpf, D., Mao, C.-A., Yamanaka, Y., Ralston, A., Chawengsaksophak, K., Beck, F., & Rossant, J. (2005) · Development · doi:10.1242/dev.01801 · Cited by 1,123
Self-citationA method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Warmflash, A., Sorre, B., Etoc, F., Siggia, E. D., & Brivanlou, A. H. (2014) · Nature Methods · doi:10.1038/nmeth.3016 · Cited by 885
Vertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812
Bernardo, A. S., Faial, T., Gardner, L., Niakan, K. K., Ortmann, D., Senner, C. E., Callery, E. M., Trotter, M. W., Hemberger, M., Smith, J. C., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.06.015 · Cited by 386
Developmental regulation of the Hox genes during axial morphogenesis in the mouse
Deschamps, J., & van Nes, J. (2005) · Development · doi:10.1242/dev.01897 · Cited by 375
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Metadata
- Authors
- Chawengsaksophak, K., de Graaff, W., Rossant, J., Deschamps, J., & Beck, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-05-10
- Volume
- 101
- Issue
- 20
- Pages
- 7641-7645
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969770877
- Cited by
- 309
- References
- 0
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Chawengsaksophak, K., de Graaff, W., Rossant, J., Deschamps, J., & Beck, F. (2004). Cdx2 is essential for axial elongation in mouse development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0401654101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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