The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Critical roles of interferon regulatory factor 4 in CD11bhighCD8α–dendritic cell development
Open accessAbstract
IFN regulatory factors (IRFs) are a family of transcription factors that play an essential role in the homeostasis and function of immune systems. Recent studies indicated that IRF-8 is critical for the development of CD11b low CD8α+conventional dendritic cells (DCs) and plasmacytoid DCs. Here we show that IRF-4 is important for CD11b high CD8α–conventional DCs. The development of CD11b high DCs from bone marrow of IRF-4–/–mice was severely impaired in two culture systems supplemented with either GM-CSF or Flt3-ligand. In the IRF-4–/–spleen, the number of CD4+CD8α–DCs, a major subset of CD11b high DCs, was severely reduced. IRF-4 and IRF-8 were expressed in the majority of CD11b high CD4+CD8α–DCs and CD11b low CD8α+DCs, respectively, in a mutually exclusive manner. These results imply that IRF-4 and IRF-8 selectively play critical roles in the development of the DC subsets that express them.
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Cites
IRF Family of Transcription Factors as Regulators of Host Defense
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Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
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Self-citationPip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
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PU. 1 is required for myeloid-derived but not lymphoid-derived dendritic cells
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Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259
The role of myeloid cells in cancer therapies
Engblom, C., Pfirschke, C., & Pittet, M. J. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.54 · Cited by 788
Re(de)fining the dendritic cell lineage
Satpathy, A. T., Wu, X., Albring, J. C., & Murphy, K. M. (2012) · Nature Immunology · doi:10.1038/ni.2467 · Cited by 441
Tamura, T., Tailor, P., Yamaoka, K., Kong, H. J., Tsujimura, H., O’Shea, J. J., Singh, H., & Ozato, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2573 · Cited by 423
Metadata
- Authors
- Suzuki, S., Honma, K., Matsuyama, T., Suzuki, K., Toriyama, K., Akitoyo, I., Yamamoto, K., Suematsu, T., Nakamura, M., Yui, K., & Kumatori, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06-07
- Volume
- 101
- Issue
- 24
- Pages
- 8981-8986
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063277895
- Cited by
- 318
- References
- 6
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Suzuki, S., Honma, K., Matsuyama, T., Suzuki, K., Toriyama, K., Akitoyo, I., Yamamoto, K., Suematsu, T., Nakamura, M., Yui, K., & Kumatori, A. (2004). Critical roles of interferon regulatory factor 4 in CD11bhighCD8α–dendritic cell development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0402139101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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