The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The human and African green monkey TRIM5α genes encode Ref1 and Lv1 retroviral restriction factor activities
Open accessAbstract
The rhesus macaque tripartite motif containing protein TRIM5α specifically restricts HIV-1 infection at an early post-entry step before reverse transcription [Stremlau, M., Owens, C. M., Perron, M. J., Kiessling, M., Autissier, P. & Sodroski, J. (2004) Nature 427, 848–853]. Here, we show that the human and African green monkey (AGM) TRIM5α genes encode Ref1 and Lv1 antiretroviral activities, respectively. Expression of TRIM5α in permissive cat cells renders them resistant to restriction-sensitive murine leukemia virus but not closely related insensitive virus. Disruption of TRIM5α expression in human and AGM cells with small interfering RNA rescues infectivity of restricted virus without affecting unrestricted virus. We also demonstrate that the activity of the murine restriction factor Fv1 depends on TRIM5α expression when Fv1 is expressed in human cells. Furthermore, a drug that modifies the behavior of the related promyelocytic leukemia protein PML specifically rescues infection by viruses restricted by human TRIM5α. Alignment of the TRIM5α proteins from rhesus macaque and AGM indicates an 18-aa insertion. We speculate that this insertion may contribute to the broader specificity of the AGM TRIM5α restriction as compared with the human and rhesus macaque proteins.
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Cites
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein
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The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
Stremlau, M., Owens, C. M., Perron, M. J., Kiessling, M., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,816
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
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DNA Deamination Mediates Innate Immunity to Retroviral Infection
Harris, R. S., Bishop, K. N., Sheehy, A. M., Craig, H. M., Petersen-Mahrt, S. K., Watt, I. N., Neuberger, M. S., & Malim, M. H. (2003) · Cell · doi:10.1016/s0092-8674(03)00423-9 · Cited by 1,266
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
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Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by Vif
Mariani, R., Chen, D., Schröfelbauer, B., Navarro, F., König, R., Bollman, B., Münk, C., Nymark-McMahon, H., & Landau, N. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00515-4 · Cited by 903
HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
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Hypermutation of HIV-1 DNA in the Absence of the Vif Protein
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Positional cloning of the mouse retrovirus restriction gene Fvl
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Self-citation
Cited by
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Nisole, S., Stoye, J. P., & Saïb, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1248 · Cited by 761
Sawyer, S. L., Wu, L. I., Emerman, M., & Malik, H. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409853102 · Cited by 688
Stremlau, M., Perron, M., Welikala, S., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3139-3145.2005 · Cited by 373
A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
Nisole, S., Lynch, C., Stoye, J. P., & Yap, M. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404640101 · Cited by 304
Two-stepping through time: mammals and viruses
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Metadata
- Authors
- Keckesova, Z., Ylinen, L. M. J., & Towers, G. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-07-12
- Volume
- 101
- Issue
- 29
- Pages
- 10780-10785
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2051777873
- Cited by
- 344
- References
- 37
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- green
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