The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors
Open accessAbstract
Stable genetic modification of adult stem cells is fundamental for both developmental studies and therapeutic purposes. Using in vivo marking studies, we showed that injection of lentiviral vectors (LVs) into the subventricular zone of the adult mouse brain enables efficient gene transfer into long-term self-renewing neural precursors and steady, robust vector expression in their neuronal progeny throughout the subventricular zone and its rostral extension, up to the olfactory bulb. By clonal and population analysis in culture, we proved that in vivo -marked neural precursors display self-renewal and multipotency, two essential characteristics of neural stem cells (NSCs). Thus, LVs efficiently target long-term repopulating adult NSCs, and the effect of the initial transduction is amplified by the continuous generation of NSC-derived, transduced progeny. LVs may thus allow novel studies on NSCs' physiology in vivo , and introduction of therapeutic genes into NSCs may allow the development of novel approaches for untreatable CNS diseases.
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Cites
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Self-citationSubventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Self-citationNeural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
Self-citationMorshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
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Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Self-citationWnt signalling regulates adult hippocampal neurogenesis
Lie, D.-C., Colamarino, S. A., Song, H.-J., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,518
Self-citationAdult neurogenesis and functional plasticity in neuronal circuits
Lledo, P.-M., Alonso, M., & Grubb, M. S. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1867 · Cited by 1,366
Vescovi, A. L., Galli, R., & Reynolds, B. A. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1889 · Cited by 990
Self-citationSuh, H., Consiglio, A., Ray, J., Sawai, T., D'Amour, K. A., & Gage, F. H. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.09.002 · Cited by 818
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Metadata
- Authors
- Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F. H., Vescovi, A. L., & Naldini, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-10-04
- Volume
- 101
- Issue
- 41
- Pages
- 14835-14840
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2120733119
- Cited by
- 166
- References
- 6
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Consiglio, A., Gritti, A., Dolcetta, D., Follenzi, A., Bordignon, C., Gage, F. H., Vescovi, A. L., & Naldini, L. (2004). Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404180101
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