Detection, stimulation, and inhibition of neuronal signals with high-density nanowire transistor arrays.
Abstract
We report electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation. Arrays of nanowire-neuron junctions enable simultaneous measurement of the rate, amplitude, and shape of signals propagating along individual axons and dendrites. The configuration of nanowire-axon junctions in arrays, as both inputs and outputs, makes possible controlled studies of partial to complete inhibition of signal propagation by both local electrical and chemical stimuli. In addition, nanowire-axon junction arrays were integrated and tested at a level of at least 50 "artificial synapses" per neuron.
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An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites.
“An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites (Freitas, 1999b; Zeck and Fromherz, 2001; Patolsky et al., 2006).”
From Human Brain/Cloud Interface (2019) · cites this paper as Patolsky et al., 2006
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- Authors
- Patolsky, F., Timko, B. P., Yu, G., Fang, Y., Greytak, A. B., Zheng, G., & Lieber, C. M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Patolsky, Fernando
- Timko, Brian P.
- Lieber, Charles M.
- ORCID
- Venue
- Science
- Published
- 2006-08-25
- Volume
- 313
- Issue
- 5790
- Pages
- 1100-1104
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079148569
- Cited by
- 832
- References
- 1
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 14 · 2021: 31 · 2020: 23 · 2019: 36 · 2018: 41 · 2017: 39 · 2016: 38 · 2015: 45 · 2014: 58 · 2013: 72 · 2012: 57
- FWCI
- 21.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Scholar Commons (University of South Carolina) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Nanowire Synthesis and Applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- nanowire field-effect transistors, axons, dendrites, electrical stimulation of neurons, artificial synapses, chemical stimulation
- MeSH terms
- Action Potentials, Animals, Axons, Cells, Cultured, Dendrites, Electric Conductivity, Electric Stimulation, Electrophysiology, Microelectrodes, Neural Inhibition, Neurons, Rats, Inbred F344, Silicon, Synapses, Transistors, Electronic, Neurites, Rats, Sprague-Dawley, Nanostructures, Rats
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