The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae
Open accessAbstract
Recently, we and others have identified two human endogenous retroviruses that entered the primate lineage 25–40 million years ago and that encode highly fusogenic retroviral envelope proteins (syncytin-1 and -2), possibly involved in the formation of the placenta syncytiotrophoblast layer generated by trophoblast cell fusion at the materno–fetal interface. A systematic in silico search throughout mouse genome databases presently identifies two fully coding envelope genes, present as unique copies and unrelated to any known murine endogenous retrovirus, that we named syncytin-A and -B. Quantitative RT-PCR demonstrates placenta-specific expression for both genes, with increasing transcript levels in this organ from 9.5 to 14.5 days postcoitum. In situ hybridization of placenta cryosections further localizes these transcripts in the syncytiotrophoblast-containing labyrinthine zona. Consistently, we show that both genes can trigger cell–cell fusion in ex vivo transfection assays, with distinct cell type specificities suggesting different receptor usage. Genes orthologous to syncytin-A and -B and disclosing a striking conservation of their coding status are found in all Muridae tested (mouse, rat, gerbil, vole, and hamster), dating their entry into the rodent lineage ≈20 million years ago. Together, these data strongly argue for a critical role of syncytin-A and -B in murine syncytiotrophoblast formation, thus unraveling a rather unique situation where two pairs of endogenous retroviruses, independently acquired by the primate and rodent lineages, would have been positively selected for a convergent physiological role.
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Cites
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
Mi, S., Lee, X., Li, X.-P., Veldman, G. M., Finnerty, H., Racie, L., LaVallie, E., Tang, X.-Y., Edouard, P., Howes, S., et al. (2000) · Nature · doi:10.1038/35001608 · Cited by 1,658
Placental development: Lessons from mouse mutants
Rossant, J., & Cross, J. C. (2001) · Nature Reviews Genetics · doi:10.1038/35080570 · Cited by 1,273
Evidence for higher rates of nucleotide substitution in rodents than in man.
Wu, C. I., & Li, W. H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.6.1741 · Cited by 913
Blond, J.-L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F., & Cosset, F.-L. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3321-3329.2000 · Cited by 716
Comparative Developmental Anatomy of the Murine and Human Definitive Placentae
Georgiades, P., Ferguson-Smith, A. C., & Burton, G. J. (2002) · Placenta · doi:10.1053/plac.2001.0738 · Cited by 641
Jenkins, N. A., Copeland, N. G., Taylor, B. A., & Lee, B. K. (1982) · Journal of Virology · doi:10.1128/jvi.43.1.26-36.1982 · Cited by 598
Blaise, S., de Parseval, N., Bénit, L., & Heidmann, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132646100 · Cited by 566
Self-citationRetroelements and the human genome: New perspectives on an old relation
Bannert, N., & Kurth, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404838101 · Cited by 516
Cited by
Mechanisms of membrane fusion: disparate players and common principles
Martens, S., & McMahon, H. T. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2417 · Cited by 710
The Role of Hypoxia in Development of the Mammalian Embryo
Dunwoodie, S. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.008 · Cited by 651
Effects of Retroviruses on Host Genome Function
Jern, P., & Coffin, J. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091501 · Cited by 499
Volff, J. (2006) · BioEssays · doi:10.1002/bies.20452 · Cited by 419
Paleovirology of ‘ syncytins ’, retroviral env genes exapted for a role in placentation
Lavialle, C., Cornelis, G., Dupressoir, A., Esnault, C., Heidmann, O., Vernochet, C., & Heidmann, T. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0507 · Cited by 413
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Metadata
- Authors
- Dupressoir, A., Marceau, G., Vernochet, C., Bénit, L., Kanellopoulos, C., Sapin, V., & Heidmann, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-01-11
- Volume
- 102
- Issue
- 3
- Pages
- 725-730
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1981662437
- Cited by
- 385
- References
- 38
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Dupressoir, A., Marceau, G., Vernochet, C., Bénit, L., Kanellopoulos, C., Sapin, V., & Heidmann, T. (2005). Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406509102
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