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Cited by 329

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain

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Feire, Adam L., Koss, Heidi, Compton, Teresa·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0406821101
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Abstract

Human cytomegalovirus (HCMV) is capable of manifesting disease in nearly every organ system in immunocompromised patients. This broad pathogenic tropism correlates with the ability of the virus to infect all tested vertebrate cell types in vitro , a characteristic that has made receptor identification extremely difficult. During virus entry, HCMV induces cellular morphological changes and signaling cascades consistent with engagement of cellular integrins; however, HCMV structural proteins do not possess the widely used RGD integrin-binding motif. We identified an integrin-binding disintegrin-like domain within HCMV envelope glycoprotein B, a protein required for virus entry and fusion throughout the Herpesviridae . Accepted receptor criteria are met through the use of function-blocking integrin Abs, β1 integrin knockout mouse fibroblasts, and glycoprotein B disintegrin-like peptides, all of which support a critical role for α2β1, α6β1, and αVβ3 integrins as HCMV entry receptors and signaling mediators acting during the penetration stage of the entry pathway. Strikingly, the glycoprotein B disintegrin-like domain is conserved in many human and animal herpesviruses, suggesting that integrins may support entry across this medically important virus family.

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Crossref · 10.1073/pnas.0406821101

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Metadata

Authors
Feire, A. L., Koss, H., & Compton, T.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-10-19
Volume
101
Issue
43
Pages
15470-15475
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0406821101
OpenAlex
W2104124112
Cited by
329
References
33
FWCI
11.71
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. https://app.cochat.ai/papers/10.1073/pnas.0406821101
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Feire, A. L., Koss, H., & Compton, T. (2004). Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406821101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.