Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor
Open accessAbstract
Neurotrophins play an important role in modulating activity-dependent neuronal plasticity. In particular, threshold levels of brain-derived neurotrophic factor (BDNF) are required to induce long-term potentiation (LTP) in acute hippocampal slices. Conversely, the administration of exogenous BDNF prevents the induction of long-term depression (LTD) in the visual cortex. A long-standing missing link in the analysis of this modulatory role of BDNF was the determination of the time-course of endogenous BDNF secretion in the same organotypic preparation in which LTP and LTD are elicited. Here, we fulfilled this requirement in slices of perirhinal cortex. Classical theta-burst stimulation patterns evoking LTP lasting >180 min elicited a large increase in BDNF secretion that persisted 5-12 min beyond the stimulation period. Weaker theta-burst stimulation patterns leading only to the initial phase of LTP (≈35 min) were accompanied by a smaller increase in BDNF secretion lasting <1 min. Sequestration of BDNF by TrkB-IgG receptor bodies prevented LTP. Low-frequency stimulations leading to LTD were accompanied by reductions in BDNF secretion that never lasted beyond the duration of the stimulation.
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The secretion of BDNF is responsive to the synchrony of synaptic input and postsynaptic spikes.
“Because BDNF secretion is not induced by a 1-Hz spike train alone (22, 23), our data suggest that the secretion of this neurotrophin is responsive to the synchrony of synaptic input and postsynaptic spikes.”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [23]
The cited paper’s Results (‘Decrease of Endogenous BDNF Secretion During LTD’) report that 1-Hz stimulation reduced BDNF secretion rather than increasing it. That supports the cited premise that 1-Hz stimulation does not induce secretion, but the paper stimulated afferent fibers; it did not test a postsynaptic spike train alone or whether synchrony with synaptic input governs secretion. The synchrony statement is presented as the citing authors’ inference, not as a finding directly attributed to this source. (LLM, conf=0.84)
Experimental — accuracy not yet measuredBDNF secretion is not induced by a 1-Hz spike train alone.
“Because BDNF secretion is not induced by a 1-Hz spike train alone (22, 23), our data suggest that the secretion of this neurotrophin is responsive to the synchrony of synaptic input and postsynaptic spikes.”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [23]
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- Authors
- Aicardi, G., Argilli, E., Cappello, S., Santi, S., Riccio, M., Thoenen, H., & Canossa, M.
- Affiliations
- Istituto Ortopedico Rizzoli (IT)
- Corresponding author
- Aicardi, Giorgio
- Argilli, Emanuela
- Cappello, Silvia
- Canossa, Marco
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-10-25
- Volume
- 101
- Issue
- 44
- Pages
- 15788-15792
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC524856
- OpenAlex
- W2016843660
- Cited by
- 246
- References
- 4
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 7 · 2019: 14 · 2018: 9 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 13 · 2013: 23 · 2012: 5
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- Regeneron Pharmaceuticals
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Max-Planck-Gesellschaft
- Università di Bologna
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- brain-derived neurotrophic factor, long-term potentiation, long-term depression, BDNF secretion, theta burst stimulation, perirhinal cortex, TrkB receptor, neurotrophins, activity-dependent plasticity, low-frequency stimulation, hippocampus
- MeSH terms
- Animals, Brain, Electrophysiology, Hippocampus, Male, Rats, Sprague-Dawley, Long-Term Potentiation, Entorhinal Cortex, Brain-Derived Neurotrophic Factor, Long-Term Synaptic Depression, Rats, In Vitro Techniques
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