The lighter side of BDNF
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early development, adult neurogenesis, and neural plasticity; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure. The possibility that “faulty” circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. Hypothalamic BDNF and TrkB appear to inhibit food intake and increase energy expenditure, leading to negative energy balance. In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity.
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BDNF affects the regulation of feeding and energy metabolism.
“BDNF is known to affect the regulation of feeding and energy metabolism [218–221].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [218]
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Progress in the development of kynurenine and quinoline-3-carboxamide-derived drugs
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The Role of Ventromedial Hypothalamus Receptors in the Central Regulation of Food Intake
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Yan, W., Zhang, L., Lv, F., Moccia, M., Carlomagno, F., Landry, C., Santoro, M., Gosselet, F., Frett, B., & Li, H. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113265 · Cited by 33 · see citing works
Lühder, F., Gold, R., Flügel, A., & Linker, R. A. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0211-0 · Cited by 33 · see citing works
Role of orexin receptors in obesity: from cellular to behavioral evidence
Perez‐Leighton, C. E., Butterick-Peterson, T. A., Billington, C. J., & Kotz, C. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.30 · Cited by 33 · see citing works
Self-citationSignal processing in the vagus nerve: Hypotheses based on new genetic and anatomical evidence
Shaffer, C., Barrett, L. F., & Quigley, K. S. (2023) · Biological Psychology · doi:10.1016/j.biopsycho.2023.108626 · Cited by 33 · see citing works
Aranda-Orgillés, B., Rutschow, D., Zeller, R., Karagiannidis, A. I., Köhler, A., Chen, C., Wilson, T. J., Krause, S., Roepcke, S., Lilley, D. M. J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.224451 · Cited by 31 · see citing works
- Authors
- Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Wang, ChuanFeng
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2011-05
- Volume
- 300
- Issue
- 5
- Pages
- R1053-R1069
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- PMC
- PMC3293512
- OpenAlex
- W2096180958
- Cited by
- 284
- References
- 292
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 13 · 2020: 23 · 2019: 15 · 2018: 15 · 2017: 15 · 2016: 25 · 2015: 25 · 2014: 23 · 2013: 28 · 2012: 28
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK080782)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- brain-derived neurotrophic factor, TrkB receptor, hypothalamus, hippocampus, energy homeostasis, feeding behavior, energy expenditure, neurogenesis, neuroplasticity, obesity, eating disorders, neurotrophins
- MeSH terms
- Animals, Feeding and Eating Disorders, Brain, Eating, Energy Metabolism, Feeding Behavior, Homeostasis, Humans, Neuronal Plasticity, Obesity, Signal Transduction, Brain-Derived Neurotrophic Factor, Receptor, trkB, Neurogenesis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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