Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

What are the functional consequences of neurocognitive deficits in schizophrenia?

(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516 · see citing works

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775 · see citing works

De novo mutations in schizophrenia implicate synaptic networks

Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works

Dendritic spine pathology in neuropsychiatric disorders

Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works

A polygenic burden of rare disruptive mutations in schizophrenia

Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212 · see citing works

Long-term Antipsychotic Treatment and Brain Volumes

Ho, B., Andreasen, N. C., Ziebell, S., Pierson, R. K., & Magnotta, V. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.199 · Cited by 975 · see citing works

Mouse and rat <i>BDNF</i> gene structure and expression revisited

Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

Renier, N., Adams, E. L., Kirst, C., Wu, Z., Azevedo, R., Kohl, J., Autry, A. E., Kadiri, L., Umadevi Venkataraju, K., Zhou, Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.007 · Cited by 918 · see citing works

Atypical antipsychotics: Mechanism of action

Seeman, P. (2002) · The Canadian Journal of Psychiatry · doi:10.1177/070674370204700106 · Cited by 899 · see citing works

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874 · see citing works

Treatment of bipolar disorder

Geddes, J. R., & Miklowitz, D. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60857-0 · Cited by 848 · see citing works

Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works

Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking

Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 768 · see citing works

AP-1 in mouse development and tumorigenesis

Jochum, W., Passegue, E. A., & Wagner, E. F. (2001) · Oncogene · doi:10.1038/sj.onc.1204389 · Cited by 734 · see citing works

Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., & Kuhl, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5734 · Cited by 706 · see citing works

Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system.

Hughes, P. E., & Dragunow, M. (1995) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06819-x · Cited by 680 · see citing works

Serial two-photon tomography for automated ex vivo mouse brain imaging

Ragan, T. M., Kadiri, L. R., Venkataraju, K. U., Bahlmann, K., Sutin, J. D. B., Taranda, J., Arganda‐Carreras, I., Kim, Y., Seung, H. S., & Osten, P. (2012) · Nature Methods · doi:10.1038/nmeth.1854 · Cited by 659 · see citing works

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

Cannon, T. D., Chung, Y., He, G., Sun, D., Jacobson, A., van Erp, T. G. M., McEwen, S., Addington, J., Bearden, C. E., Cadenhead, K., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.023 · Cited by 599 · see citing works

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

Guillin, O., Díaz, J., Carroll, P., Griffon, N., Schwartz, J.-C., & Sokoloff, P. (2001) · Nature · doi:10.1038/35075076 · Cited by 573 · see citing works

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533 · see citing works

Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.

O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471 · see citing works

Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis

Green, M. J., Matheson, S. L., Shepherd, A., Weickert, C. S., & Carr, V. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.88 · Cited by 453 · see citing works

Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate GyrusIn Vivo

Messaoudi, E., Kanhema, T., Soule, J. D., Tiron, A., Dagytė, G., da Silva, B., & Bramham, C. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2883-07.2007 · Cited by 452 · see citing works

The Arc of synaptic memory

Bramham, C. R., Alme, M. N., Bittins, M., Kuipers, S. D., Nair, R. R., Pai, B., Panja, D., Schubert, M., Soule, J., Tiron, A., et al. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1959-2 · Cited by 452 · see citing works

The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles

Maxwell, M., & Muscat, G. E. O. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04002 · Cited by 447 · see citing works

Prefrontal function in schizophrenia: confounds and controversies

Weinberger, D. R., & Berman, K. F. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0135 · Cited by 414 · see citing works

ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons

Alonso, M., Medina, J. H., & Pozzo-Miller, L. (2004) · Learning &amp; Memory · doi:10.1101/lm.67804 · Cited by 412 · see citing works

Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission

Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works

The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB

Xu, B., Gottschalk, W., Chow, A., Wilson, R. I., Schnell, E., Zang, K., Wang, D., Nicoll, R. A., Lu, B., & Reichardt, L. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06888.2000 · Cited by 401 · see citing works

Identification of a new brain-specific transcription factor, NURR1

Law, S. W. T., Conneely, O. M., DeMayo, F. J., & O’Malley, B. W. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.12.1491694 · Cited by 399 · see citing works

Balance and Stability of Synaptic Structures during Synaptic Plasticity

Meyer, D., Bonhoeffer, T., & Scheuss, V. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.031 · Cited by 395 · see citing works

The Neurobiology of Cocaine Addiction

Nestler, E. (2005) · Science &amp; Practice Perspectives · doi:10.1151/spp05314 · Cited by 367 · see citing works

Egr transcription factors in the nervous system

Beckmann, A. M., & Wilce, P. A. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00136-2 · Cited by 347 · see citing works

Immediate-Early Genes and Synaptic Function

Lanahan, A. A., & Worley, P. F. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3836 · Cited by 344 · see citing works

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

Waterhouse, E. G., & Xu, B. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.06.009 · Cited by 341 · see citing works

Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF

Pang, P. T., & Lu, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.07.002 · Cited by 337 · see citing works

Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine.

Nguyen, T., Kosofsky, B. E., Birnbaum, R., Cohen, B. M., & Hyman, S. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4270 · Cited by 331 · see citing works

Calcium regulation of gene expression in neuronal cells

Ghosh, A., Ginty, D. D., Bading, H., & Greenberg, M. E. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250309 · Cited by 326 · see citing works

The Homer family proteins.

Shiraishi‐Yamaguchi, Y., & Furuichi, T. (2007) · Genome biology · doi:10.1186/gb-2007-8-2-206 · Cited by 324 · see citing works

Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons

Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works

Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity

Tsui, C., Copeland, N., Gilbert, D., Jenkins, N., Barnes, C., & Worley, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02463.1996 · Cited by 315 · see citing works

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.

Robertson, G. S., Matsumura, H., & Fibiger, H. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23800-9 · Cited by 311 · see citing works

Experience-Dependent Coincident Expression of the Effector Immediate-Early Genes Arc and Homer 1a in Hippocampal and Neocortical Neuronal Networks

Vazdarjanova, A. I., McNaughton, B. L., Barnes, C. A., Worley, P. F., & Guzowski, J. F. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10067.2002 · Cited by 307 · see citing works

Imaging the Addicted Human Brain

Fowler, J. S., Volkow, N. D., Kassed, C. A., & Chang, L. (2007) · Science & Practice Perspectives · doi:10.1151/spp07324 · Cited by 304 · see citing works

Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta

Baquet, Z., Bickford, P., & Jones, K. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4601-04.2005 · Cited by 301 · see citing works

Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex

González-Maeso, J., Yuen, T., Ebersole, B. J., Wurmbach, E., Lira, A., Zhou, M., Weisstaub, N., Hen, R., Gingrich, J. A., & Sealfon, S. C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08836.2003 · Cited by 297 · see citing works

How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?

Davis, S., Bozon, B., & Laroche, S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00421-7 · Cited by 281 · see citing works

The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies

Vita, A., Peri, L. M. D., Deste, G., Barlati, S., & Sacchetti, E. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.008 · Cited by 274 · see citing works

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

Ortega-Martinez, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00046 · Cited by 263 · see citing works

Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a

Hu, J.-H., Park, J. M., Park, S. J., Xiao, B., Dehoff, M. H., Kim, S., Hayashi, T., Schwarz, M. K., Huganir, R. L., Seeburg, P. H., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.008 · Cited by 263 · see citing works

BDNF gene is a risk factor for schizophrenia in a Scottish population

Neves-Pereira, M., Cheung, J., Pasdar, A., Zhang, F., Breen, G. D., Yates, P., Sinclair, M., Crombie, C., Walker, N. P., & Clair, D. M. S. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001575 · Cited by 262 · see citing works

Mechanisms of action of atypical antipsychotic drugs

Deutch, A. Y., Moghaddam, B., Innis, R. B., Krystal, J. H., Aghajanian, G. K., Bunney, B. S., & Charney, D. S. (1991) · Schizophrenia Research · doi:10.1016/0920-9964(91)90030-u · Cited by 253 · see citing works

Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment

de Foubert, G., Carney, S. L., Robinson, C. S., Destexhe, E. J., Tomlinson, R., Hicks, C. A., Murray, T. K., Gaillard, J. P., Deville, C., Xhenseval, V., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.054 · Cited by 249 · see citing works

Synaptopathies: diseases of the synaptome

Grant, S. G. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.002 · Cited by 248 · see citing works

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor

Aicardi, G., Argilli, E., Cappello, S., Santi, S., Riccio, M., Thoenen, H., & Canossa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406960101 · Cited by 246 · see citing works

Arc regulates spine morphology and maintains network stability in vivo

Peebles, C. L., Yoo, J., Thwin, M. T., Palop, J. J., Noebels, J. L., & Finkbeiner, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006546107 · Cited by 245 · see citing works

Expression of brain‐derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs

Bai, O., Chlan‐Fourney, J., Bowen, R., Keegan, D. A., & Li, X. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10440 · Cited by 239 · see citing works

A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites

Steward, O., & Worley, P. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131146398 · Cited by 225 · see citing works

Homer Proteins Regulate Sensitivity to Cocaine

Szumlinski, K. K., Dehoff, M. H., Kang, S. H., Frys, K. A., Lominac, K. D., Klugmann, M., Rohrer, J., Griffin, W. C., Toda, S., Champtiaux, N., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.019 · Cited by 224 · see citing works

Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain

Raivich, G., & Behrens, A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.006 · Cited by 222 · see citing works

∆FosB: A transcriptional regulator of stress and antidepressant responses

Nestler, E. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.034 · Cited by 220 · see citing works

Synaptic Activity-Induced Conversion of Intronic to Exonic Sequence in Homer 1 Immediate Early Gene Expression

Bottai, D., Guzowski, J. F., Schwarz, M. K., Kang, S. H., Xiao, B., Lanahan, A. A., Worley, P. F., & Seeburg, P. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00167.2002 · Cited by 217 · see citing works

Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia

Castner, S., Goldman-Rakic, P., & Williams, G. V. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1710-9 · Cited by 217 · see citing works

Making protein interactions druggable: targeting PDZ domains

Dev, K. K. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1578 · Cited by 197 · see citing works

BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs

Lipska, B. K., Khaing, Z. Z., Weickert, C. S., & Weinberger, D. R. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01633.x · Cited by 195 · see citing works

Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism

de Bartolomeis, A., Tomasetti, C., & Iasevoli, F. (2015) · CNS Drugs · doi:10.1007/s40263-015-0278-3 · Cited by 192 · see citing works

Behavioral and neurochemical phenotyping of <i>Homer1</i> mutant mice: possible relevance to schizophrenia

Szumlinski, K. K., Lominac, K. D., Kleschen, M. J., Oleson, E. B., Dehoff, M. H., Schwartz, M. K., Seeberg, P. H., Worley, P. F., & Kalivas, P. W. (2005) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00120.x · Cited by 181 · see citing works

Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence

Wallace, C. S., Lyford, G. L., Worley, P. F., & Steward, O. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00026.1998 · Cited by 171 · see citing works

Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor.

Rex, C., Lauterborn, J., Lin, C.-Y., Kramár, E., Rogers, G., Gall, C., & Lynch, G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00336.2006 · Cited by 169 · see citing works

Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters

Lauterborn, J. C., Rivera, S., Stinis, C., Hayes, V. Y., Isackson, P. J., & Gall, C. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07428.1996 · Cited by 166 · see citing works

Induction of c‐fos mRNA Expression in Rat Striatum by Neuroleptic Drugs

Miller, J. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01983.x · Cited by 164 · see citing works

Structural Basis of Arc Binding to Synaptic Proteins: Implications for Cognitive Disease

Zhang, W., Wu, J., Ward, M. D., Yang, S., Chuang, Y.-A., Xiao, M.-F., Li, R., Leahy, D. J., & Worley, P. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.030 · Cited by 162 · see citing works

Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons

Chen, W., West, A. E., Xu, T., Corfas, G., Szentirmay, M. N., Sawadogo, M., Vinson, C., & Greenberg, M. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02572.2003 · Cited by 161 · see citing works

Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons

O'Brien, R., Xu, D., Mi, R., Tang, X., Hopf, C., & Worley, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04487.2002 · Cited by 160 · see citing works

Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics

GRILLO, R., Ottoni, G. L., Leke, R., Souza, D. O., Portela, L. V., & Lara, D. R. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.005 · Cited by 159 · see citing works

Memory Reconsolidation Mediates the Updating of Hippocampal Memory Content

Lee, J. L. C. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00168 · Cited by 153 · see citing works

Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja

MacGibbon, G. A., Lawlor, P. A., Bravo, R., & Dragunow, M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90207-0 · Cited by 152 · see citing works

Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics

Tan, Y. L., Zhou, D. F., Cao, L. Y., Zou, Y. Z., & Zhang, X. Y. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.02.054 · Cited by 146 · see citing works

Presynaptic neuronal pentraxin receptor organizes excitatory and inhibitory synapses

Lee, S.-J., Wei, M., Zhang, C., Maxeiner, S., Pak, C., Calado Botelho, S., Trotter, J., Sterky, F. H., & Südhof, T. C. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2768-16.2016 · Cited by 146 · see citing works

The Neuronal Activity-Driven Transcriptome

Benito, E., & Barco, Á. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8772-z · Cited by 145 · see citing works

Role of dopamine D(2) receptors for antipsychotic activity.

Ginovart, N., & Kapur, S. (2012) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25761-2_2 · Cited by 145 · see citing works

An association study of a brain-derived neurotrophic factor Val66Met polymorphism and clozapine response of schizophrenic patients

Hong, C., Yu, Y. W. ‐., Lin, C., & Tsai, S. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00828-0 · Cited by 144 · see citing works

A Specific Requirement of Arc/Arg3.1 for Visual Experience-Induced Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex

Gao, M., Sossa, K. G., Song, L., Errington, L., Cummings, L. W., Hwang, H., Kuhl, D., Worley, P. F., & Lee, H. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-10.2010 · Cited by 144 · see citing works

Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK

Panja, D., Kenney, J. W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C. G., & Bramham, C. R. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.016 · Cited by 143 · see citing works

Hippocampal Long-Term Potentiation Is Supported by Presynaptic and Postsynaptic Tyrosine Receptor Kinase B-Mediated Phospholipase Cγ Signaling

Gärtner, A., Polnau, D. G., Staiger, V., Sciarretta, C., Minichiello, L., Thoenen, H., Bonhoeffer, T., & Körte, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3792-05.2006 · Cited by 137 · see citing works

Activation and function of immediate-early genes in the nervous systemThis paper is one of a selection of papers in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

Pérez-Cadahía, B., Drobic, B., & Davie, J. R. (2011) · Biochemistry and Cell Biology · doi:10.1139/o10-138 · Cited by 137 · see citing works

Effects of Olanzapine on Regional C-Fos Expression in Rat Forebrain

Robertson, G. S., & Fibiger, H. C. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00196-k · Cited by 135 · see citing works

BDNF-mediated neurotransmission relies upon a myosin VI motor complex

Yano, H., Ninan, I., Zhang, H., Milner, T. A., Arancio, O., & Chao, M. V. (2006) · Nature Neuroscience · doi:10.1038/nn1730 · Cited by 134 · see citing works

Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum

White, N. M., & Hiroi, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6486 · Cited by 131 · see citing works

Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration

Chlan‐Fourney, J., Ashe, P. C., Nylen, K., Juorio, A. V., & Li, X. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03215-8 · Cited by 129 · see citing works

Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus

Pillai, A., Terry, A. V., & Mahadik, S. P. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.021 · Cited by 127 · see citing works

Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits

Tost, H., Braus, D. F., Hakimi, S., Ruf, M., Vollmert, C., Höhn, F., & Meyer‐Lindenberg, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2572 · Cited by 127 · see citing works

Glutamatergic Postsynaptic Density Protein Dysfunctions in Synaptic Plasticity and Dendritic Spines Morphology: Relevance to Schizophrenia and Other Behavioral Disorders Pathophysiology, and Implications for Novel Therapeutic Approaches

de Bartolomeis, A., Latte, G., Tomasetti, C., & Iasevoli, F. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8534-3 · Cited by 126 · see citing works

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

Shin, S. M., Zhang, N., Hansen, J., Gerges, N. Z., Pak, D. T. S., Sheng, M., & Lee, S. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3259 · Cited by 126 · see citing works

The transcription factor Fos: a Janus-type regulator in health and disease.

Durchdewald, M., Angel, P. E., & Heß, J. (2009) · PubMed · doi:10.14670/hh-24.1451 · Cited by 124 · see citing works

Adult mice with reduced Nurr1 expression: an animal model for schizophrenia

Rojas, P., Joodmardi, E., Hong, Y., Perlmann, T., & Ögren, S. O. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001993 · Cited by 118 · see citing works

Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning

Lonergan, M. E., Gafford, G. M., Jarome, T. J., & Helmstetter, F. J. (2010) · Neural Plasticity · doi:10.1155/2010/139891 · Cited by 117 · see citing works

A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain

Bäckman, C. M., Perlmann, T., Wallén‐Mackenzie, Å., Hoffer, B. J., & Morales, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02149-6 · Cited by 117 · see citing works

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia

Managò, F., Mereu, M., Mastwal, S. S., Mastrogiacomo, R., Scheggia, D., Emanuele, M., Luca, M. A. D., Weinberger, D. R., Wang, K. H., & Papaleo, F. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.044 · Cited by 117 · see citing works

Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

Saunderson, E. A., Spiers, H., Mifsud, K. R., Gutièrrez‐Mecinas, M., Trollope, A. F., Shaikh, A., Mill, J. S., & Reul, J. M. H. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524857113 · Cited by 113 · see citing works

Less Is More: Antipsychotic Drug Effects Are Greater with Transient Rather Than Continuous Delivery

Samaha, A., Reckless, G. E., Seeman, P. M., Diwan, M., Nóbrega, J. N., & Kapur, S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.010 · Cited by 110 · see citing works

Npas4: A Neuronal Transcription Factor with a Key Role in Social and Cognitive Functions Relevant to Developmental Disorders

Coutellier, L. D., Beraki, S., Ardestani, P. M., Saw, N. L., & Shamloo, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046604 · Cited by 109 · see citing works

Neurochemical, morphologic, and laminar characterization of cortical projection neurons in the cingulate motor areas of the macaque monkey

Nimchinsky, E. A., Hof, P. R., Young, W. G., & Morrison, J. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961007)374:1 · Cited by 105 · see citing works

Chronic Fluoxetine Treatment Induces Brain Region-Specific Upregulation of Genes Associated with BDNF-Induced Long-Term Potentiation

Alme, M. N., Wibrand, K., Dagestad, G., & Bramham, C. R. (2007) · Neural Plasticity · doi:10.1155/2007/26496 · Cited by 103 · see citing works

Differential Effects of MK-801 on Brain-Derived Neurotrophic Factor mRNA Levels in Different Regions of the Rat Brain

Ċastrén, E., Berzaghi, M. D. P., Lindholm, D., & Thoenen, H. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1124 · Cited by 101 · see citing works

Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains

Iritani, S., Niizato, K., Nawa, H., Ikeda, K., & Emson, P. C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00112-x · Cited by 101 · see citing works

Early growth response gene 1 (Egr-1) is required for new and reactivated fear memories in the lateral amygdalaPreprint

Maddox, S. A., Monsey, M. S., & Schafe, G. E. (2010) · Learning & Memory · doi:10.1101/lm.1980211 · Cited by 99 · see citing works

Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes

Steward, O., Farris, S., Pirbhoy, P. S., Darnell, J. C., & Driesche, S. J. V. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00101 · Cited by 98 · see citing works

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

Wibrand, K., Pai, B., Siripornmongcolchai, T., Bittins, M., Berentsen, B., Ofte, M. L., Weigel, A., Skaftnesmo, K. O., & Bramham, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041688 · Cited by 95 · see citing works

Molecular evidence of synaptic pathology in the CA1 region in schizophrenia

Matosin, N., Fernandez, F., Lum, J. S., Engel, M., Andrews, J. L., Gassen, N. C., Wagner, K. V., Schmidt, M. V., & Newell, K. A. (2016) · Schizophrenia · doi:10.1038/npjschz.2016.22 · Cited by 92 · see citing works

Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

Kimoto, S., Bazmi, H. H., & Lewis, D. A. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010004 · Cited by 91 · see citing works

Scaffolding Proteins of the Post-synaptic Density Contribute to Synaptic Plasticity by Regulating Receptor Localization and Distribution: Relevance for Neuropsychiatric Diseases

Iasevoli, F., Tomasetti, C., & de Bartolomeis, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0886-y · Cited by 88 · see citing works

The Homer Family and the Signal Transduction System at Glutamatergic Postsynaptic Density: Potential Role in Behavior and Pharmacotherapy

de Bartolomeis, A., Manji, H. K., PhD, Iasevoli, A. F., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4173 · Cited by 88 · see citing works

Scaffold protein Homer 1: Implications for neurological diseases

Luo, P., Li, X., Fei, Z., & Poon, W. S. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.06.014 · Cited by 87 · see citing works

Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action

Deutch, A. Y., Öngür, D., & Duman, R. S. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00571-l · Cited by 87 · see citing works

Homer Isoforms Differentially Regulate Cocaine-Induced Neuroplasticity

Szumlinski, K. K., Abernathy, K., Oleson, E. B., Klugmann, M., Lominac, K. D., He, D., Dorit Ron, A., During, M. J., & Kalivas, P. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300890 · Cited by 86 · see citing works

Differential Regulation of the Transcriptional Activity of the Orphan Nuclear Receptor NGFI-B by Membrane Depolarization and Nerve Growth Factor

Katagiri, Y., Hirata, Y., Milbrandt, J., & Guroff, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31278 · Cited by 86 · see citing works

Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders

Xing, G., Zhang, L., Russell, S., & Post, R. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.006 · Cited by 85 · see citing works

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance

Bigio, B., Mathé, A. A., Sousa, V. C., Zelli, D., Svenningsson, P., McEwen, B. S., & Nasca, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603111113 · Cited by 85 · see citing works

Contrasting Patterns and Cellular Specificity of Transcriptional Regulation of the Nuclear Receptor Nerve Growth Factor‐Inducible B by Haloperidol and Clozapine in the Rat Forebrain

Beaudry, G., Langlois, M., Weppe, I., Rouillard, C., & Lévesque, D. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751694.x · Cited by 83 · see citing works

Methylphenidate (Ritalin) induces Homer 1a and zif 268 expression in specific corticostriatal circuits

Yano, M., & Steiner, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.019 · Cited by 83 · see citing works

Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions.

Merchant, K. M., Dobie, D. J., Filloux, F. M., Totzke, M. T., Aravagiri, M., & Dorsa, D. M. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22817-8 · Cited by 83 · see citing works

Is schizophrenia a dopamine supersensitivity psychotic reaction?

Seeman, M. V., & Seeman, P. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.003 · Cited by 82 · see citing works

Nur transcription factors in stress and addiction

Campos‐Melo, D., Galleguillos, D., Sánchez, N., Gysling, K., & Andrés, M. E. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00044 · Cited by 82 · see citing works

Synaptic Dysfunction in Schizophrenia

Yin, D., Chen, Y., Sathyamurthy, A., Xiong, W., & Mei, L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_22 · Cited by 81 · see citing works

Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations

Jarskog, L. F. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218603.25346.8f · Cited by 81 · see citing works

In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain

Xie, H. B., Liu, Y., Zhu, Y., Ding, X., Yang, Y., & Guan, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316808111 · Cited by 78 · see citing works

Effect of antipsychotic drugs on brain‐derived neurotrophic factor expression under reduced N‐methyl‐D‐aspartate receptor activity

Fumagalli, F., Molteni, R., Roceri, M., Bedogni, F., Santero, R., Fossati, C., Gennarelli, M., Racagni, G., & Riva, M. A. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10609 · Cited by 77 · see citing works

BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year

Martínez‐Cengotitabengoa, M., MacDowell, K. S., Alberich, S., Diaz, F., García‐Bueno, B., Rodríguez–Jiménez, R., Bioque, M., Berrocoso, E., Parellada, M., Lobo, A., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv078 · Cited by 76 · see citing works

The Synaptic Pathology of Schizophrenia: Is Aberrant Neurodevelopment and Plasticity to Blame?

Eastwood, S. L. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59003-7 · Cited by 75 · see citing works

Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol

Parikh, V., Khan, M. M., & Mahadik, S. P. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.079 · Cited by 75 · see citing works

Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress

Fumagalli, F., Calabrese, F., Luoni, A., Bolis, F., Racagni, G., & Riva, M. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000150 · Cited by 75 · see citing works

Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats

Park, S.-W., Lee, S.-K., Kim, J.-M., Yoon, J., & Kim, Y.-H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.028 · Cited by 74 · see citing works

Expression of Neurotrophins BDNF and NT-3, and Their Receptors in Rat Brain After Administration of Antipsychotic and Psychotrophic Agents

Linden, A.-M., Väisänen, J., Lakso, M., Nawa, H., Wong, G., & Ċastrén, E. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:14:1-2:027 · Cited by 73 · see citing works

Shifting Responsibly: The Importance of Striatal Modularity to Reinforcement Learning in Uncertain Environments

Amemori, K., Gibb, L., & Graybiel, A. M. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00047 · Cited by 72 · see citing works

D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

Rinaldi, A., Mandillo, S., Oliverio, A., & Mele, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301176 · Cited by 71 · see citing works

Arc/Arg3.1 Translation Is Controlled by Convergent N-Methyl-D-aspartate and Gs-coupled Receptor Signaling Pathways

Bloomer, W. A. C., VanDongen, H. M. A., & VanDongen, A. M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702451200 · Cited by 71 · see citing works

Alterations of Dopamine D2 Receptors and Related Receptor-Interacting Proteins in Schizophrenia: The Pivotal Position of Dopamine Supersensitivity Psychosis in Treatment-Resistant Schizophrenia

Oda, Y., Kanahara, N., & Iyo, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226228 · Cited by 71 · see citing works

Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia

Shamloo, M., Soriano, L., von Schack, D., Rickhag, M., Chin, D. J., Gonzalez‐Zulueta, M., Gidö, G., Urfer, R., Wieloch, T. W., & Nikolich, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05172.x · Cited by 70 · see citing works

Transcription-Factor-Dependent Control of Adult Hippocampal NeurogenesisPreprint

Beckervordersandforth, R., Zhang, C., & Lie, D. C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018879 · Cited by 70 · see citing works

Convulsant Doses of a Dopamine D1 Receptor Agonist Result in Erk-Dependent Increases in Zif268 and Arc/Arg3.1 Expression in Mouse Dentate Gyrus

Gangarossa, G., Benedetto, M. D., O'Sullivan, G. J., Dunleavy, M., Alcacer, C., Bonito-Oliva, A., Henshall, D. C., Waddington, J. L., Valjent, E., & Fisone, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019415 · Cited by 69 · see citing works

In Vivo Regulation of Homer1a Expression in the Striatum by Cocaine

Zhang, G.-C., Mao, L., Liu, X., Parelkar, N. K., Arora, A. K., Yang, L., Hains, M., Fibuch, E. E., & Wang, J. Q. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.028399 · Cited by 69 · see citing works

Plasticity‐related genes in brain development and amygdala‐dependent learning

Ehrlich, D., & Josselyn, S. A. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12255 · Cited by 68 · see citing works

Homer 1a Gene Expression Modulation by Antipsychotic Drugs Involvement of the Glutamate Metabotropic System and Effects of D-Cycloserine

Polese, D. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00371-8 · Cited by 66 · see citing works

Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine

Calabrese, F., Molteni, R., Gabriel, C., Mocaër, E., Racagni, G., & Riva, M. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2129-8 · Cited by 64 · see citing works

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response in bipolar disorder: a multimodal genetic imaging study

Benedetti, F., Poletti, S., Locatelli, C., Mazza, E., Lorenzi, C., Vitali, A., Riberto, M., Brioschi, S., Vai, B., Bollettini, I., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.011 · Cited by 64 · see citing works

Increase in brain-derived neurotrophic factor in first episode psychotic patients after treatment with atypical antipsychotics

González-Pinto, A. M., Mosquera, F., Palomino, A., Alberich, S., Gutiérrez, A., Haidar, K., Vega, P., Barbeito, S., Jauregi, A. O., & Matute, C. (2010) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e328338bc5a · Cited by 63 · see citing works

Induction Patterns of Transcription Factors of the Nur Family (Nurr1, Nur77, and Nor-1) by Typical and Atypical Antipsychotics in the Mouse Brain: Implication for Their Mechanism of Action

Maheux, J., Éthier, I., Rouillard, C., & Lévesque, D. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.080184 · Cited by 62 · see citing works

Impact of antipsychotic drug administration on the expression of nuclear receptors in the neocortex and striatum of the rat brain

Langlois, M.-C., Beaudry, G., Zekki, H., Rouillard, C., & Lévesque, D. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00248-2 · Cited by 60 · see citing works

Psychotherapy and the Single Synapse

Kandel, E. R. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.2.290 · Cited by 60 · see citing works

Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients

Spellmann, I., Rujescu, D., Musil, R., Mayr, A. J., Giegling, I., Genius, J., Zill, P., Dehning, S., Opgen-Rhein, M., Cerovecki, A., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.06.004 · Cited by 59 · see citing works

N‐methyl‐D‐aspartate‐stimulated ERK1/2 signaling and the transcriptional up‐regulation of plasticity‐related genes are developmentally regulated following in vitro neuronal maturation

Zhou, X., Moon, C., Zheng, F., Luo, Y., Soellner, D., Nuñez, J. L., & Wang, H. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22103 · Cited by 59 · see citing works

The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge

Daunais, J. B., & McGinty, J. F. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00226-i · Cited by 58 · see citing works

Haloperidol and Clozapine Differentially Affect the Expression of Arrestins, Receptor Kinases, and Extracellular Signal-Regulated Kinase Activation

Ahmed, M. R., Gurevich, V. V., Dalby, K. N., Benovic, J., & Gurevich, E. V. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131987 · Cited by 57 · see citing works

Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine

Werme, M., Ringholm, A., Olson, L., & Brené, S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02109-0 · Cited by 57 · see citing works

Quantitatively and qualitatively different cellular processes are engaged in CA1 during the consolidation and reconsolidation of contextual fear memory

Barnes, P., Kirtley, A., & Thomas, K. L. (2010) · Hippocampus · doi:10.1002/hipo.20879 · Cited by 56 · see citing works

The development and evaluation of the Finnish Matrix Sentence Test for speech intelligibility assessment

Dietz, A., Buschermöhle, M., Aarnisalo, A. A., Vanhanen, A., Hyyrynen, T., Aaltonen, O., Löppönen, H., Zokoll, M. A., & Kollmeier, B. (2014) · Acta Oto-Laryngologica · doi:10.3109/00016489.2014.898185 · Cited by 54 · see citing works

Brain-derived neurotrophic factor enhances the hippocampal expression of key postsynaptic proteins in vivo including the monocarboxylate transporter MCT2

Robinet, C., & Pellerin, L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.059 · Cited by 54 · see citing works

Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental trainingPreprint

Hernandez, P. J., Schiltz, C. A., & Kelley, A. E. (2006) · Learning & Memory · doi:10.1101/lm.335006 · Cited by 53 · see citing works

μ‐Opioid receptor knockout mice are insensitive to methamphetamine‐induced behavioral sensitization

Shen, X., Purser, C., Tien, L., Chiu, C., Paul, I. A., Baker, R., Loh, H. H., Ho, I. K., & Ma, T. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22386 · Cited by 52 · see citing works

Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk

Huentelman, M. J., Muppana, L., Corneveaux, J. J., Dinu, V., Pruzin, J. J., Reiman, R., Borish, C. N., De Both, M., Ahmed, A., Todorov, A., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0135076 · Cited by 52 · cited 1× · see citing works

Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats

Park, S. W., Lee, C. H., Lee, J. G., Lee, S. J., Kim, N. R., Choi, S. M., & Kim, Y. H. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.05.010 · Cited by 52 · see citing works

Regional Abnormality of Grey Matter in Schizophrenia: Effect from the Illness or Treatment?

Yue, Y., Kong, L., Wang, J., Li, C., Tan, L., Su, H. L., & Xu, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147204 · Cited by 52 · see citing works

Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia

Kimoto, S., Zaki, M. M., Bazmi, H. H., & Lewis, D. A. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0533 · Cited by 51 · see citing works

Homer splice variants modulation within cortico-subcortical regions by dopamine D2 antagonists, a partial agonist, and an indirect agonist: implication for glutamatergic postsynaptic density in antipsychotics action.

Tomasetti, C., Dell’Aversano, C., Iasevoli, F., & de Bartolomeis, A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.022 · Cited by 51 · see citing works

Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia

Zai, C. C. H., Tiwari, A. K., Luca, V. D., Müller, D. J., Bulgin, N., Hwang, R., Zai, G. C., King, N. A., Voineskos, A. N., Meltzer, H. Y., et al. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.01.001 · Cited by 51 · see citing works

The differences between typical and atypical antipsychotics: the effects on neurogenesis.

Nandra, K. S., & Agius, M. A. (2012) · PubMed · Cited by 51 · see citing works

Distinctive features of Egr transcription factor regulation and DNA binding activity in CA1 of the hippocampus in synaptic plasticity and consolidation and reconsolidation of fear memory

Cheval, H., Chagneau, C., Levasseur, G., Veyrac, A., Biguet, N. F., Laroche, S., & Davis, S. (2011) · Hippocampus · doi:10.1002/hipo.20926 · Cited by 50 · see citing works

Involvement of dopaminergic and cholinergic systems in social isolation-induced deficits in social affiliation and conditional fear memory in mice

Okada, R., Fujiwara, H., Mizuki, D., Araki, R., Yabe, T., & Matsumoto, K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.064 · Cited by 50 · see citing works

Glutamate receptor activation is involved in 5-HT2 agonist-induced Arc gene expression in the rat cortex

Pei, Q., Tordera, R. M., Sprakes, M., & Sharp, T. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.09.017 · Cited by 50 · see citing works

The Transcription Factor NGFI-B (Nur77) and Retinoids Play a Critical Role in Acute Neuroleptic-Induced Extrapyramidal Effect and Striatal Neuropeptide Gene Expression

Éthier, I., Beaudry, G., St‐Hilaire, M., Milbrandt, J., Rouillard, C., & Lévesque, D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300318 · Cited by 50 · see citing works

Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole

Iasevoli, F., Tomasetti, C., Marmo, F., Bravi, D., Arnt, J., & de Bartolomeis, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1954-0 · Cited by 49 · see citing works

The acute and chronic effects of combined antipsychotic-mood stabilizing treatment on the expression of cortical and striatal postsynaptic density genes.

Tomasetti, C., Dell’Aversano, C., Iasevoli, F., Marmo, F., & de Bartolomeis, A. (2011) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.025 · Cited by 49 · see citing works

Individualizing antipsychotic drug therapy in schizophrenia: The promise of pharmacogenetics

Nnadi, C. U., & Malhotra, A. K. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0038-2 · Cited by 47 · see citing works

Excitation-Transcription Coupling via Calcium/Calmodulin-dependent Protein Kinase/ERK1/2 Signaling Mediates the Coordinate Induction of VGLUT2 and Narp Triggered by a Prolonged Increase in Glutamatergic Synaptic Activity*

Doyle, S., Pyndiah, S., Gois, S. D., & Erickson, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.080069 · Cited by 47 · see citing works

Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons

Takahashi, T., Suzuki, M., Tsunoda, M., Kawamura, Y., Takahashi, N., Tsuneki, H., Kawasaki, Y., Zhou, S.-Y., Kobayashi, S., Sasaoka, T., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.004 · Cited by 46 · see citing works

Chronic Antipsychotic Drug Treatment Induces Long-lasting Expression of fos and jun Family Genes and Activator Protein 1 Complex in the Rat Prefrontal Cortex

Kontkanen, O. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00289-0 · Cited by 45 · see citing works

Dopamine receptor subtypes contribution to Homer1a induction: Insights into antipsychotic molecular action

Iasevoli, F., Tomasetti, C., Ambesi‐Impiombato, A., Muscettola, G., & de Bartolomeis, A. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.02.009 · Cited by 45 · see citing works

Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp

Mariga, A., Glaser, J., Mathias, L., Xu, D., Xiao, M., Worley, P., Ninan, I., & Chao, M. V. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.064 · Cited by 45 · see citing works

Pattern of acute induction of Homer1a gene is preserved after chronic treatment with first- and second-generation antipsychotics: effect of short-term drug discontinuation and comparison with Homer1a-interacting genes

Iasevoli, F., Ambesi‐Impiombato, A., Fiore, G., Panariello, F., Muscettola, G., & de Bartolomeis, A. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109358199 · Cited by 44 · see citing works

Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

Chen, Q.-Y., Chen, Q., Feng, G., Wan, C., Lindpaintner, K., Wang, L., Chen, Z., Gao, Z.-S., Tang, J., Li, X.-W., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.033 · Cited by 44 · see citing works

Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens–ventral pallidum pathway

Valenti, O., & Grace, A. A. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990599 · Cited by 44 · see citing works

Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: Differential regulation by dopamine and glutamate signaling

Ghasemzadeh, M. B., Windham, L. K., LAKE, R. W., Acker, C. J., & Kalivas, P. W. (2008) · Synapse · doi:10.1002/syn.20577 · Cited by 43 · see citing works

Managing Negative Symptoms of Schizophrenia: How Far Have We Come?

Kantrowitz, J. T. (2017) · CNS Drugs · doi:10.1007/s40263-017-0428-x · Cited by 43 · see citing works

Induction of differential patterns of local cerebral glucose metabolism and immediate-early genes by acute clozapine and haloperidol

Cochran, S., McKerchar, C. E., MORRIS, B. J., & Pratt, J. A. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00091-6 · Cited by 42 · see citing works

Contrasting Effects of Chronic Clozapine, SeroquelTM (ICI 204,636) and Haloperidol Administration on ΔFosB‐like Immunoreactivity in the Rodent Forebrain

Vahid-Ansari, F., Nakabeppu, Y., & Robertson, G. S. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01579.x · Cited by 41 · see citing works

Mapping memory function in the medial temporal lobe with the immediate-early gene Arc

Sauvage, M. M., Nakamura, N. H., & Beer, Z. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.048 · Cited by 41 · see citing works

LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element

Moser, M., Knoth, R., Bode, C., & Patterson, C. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.023 · Cited by 41 · see citing works

Modulation of behavior by scaffolding proteins of the post-synaptic density

Gao, C., Tronson, N. C., & Radulović, J. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.014 · Cited by 41 · see citing works

Signaling pathways regulating Homer1a expression: implications for antidepressant therapy

Serchov, T., Heumann, R., van Calker, D., & Biber, K. P. H. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0267 · Cited by 41 · see citing works

Regulation of the Nuclear Orphan Receptor Nur77 in Bone by Parathyroid Hormone

Tetradis, S., Bezouglaia, O., Tsingotjidou, A., & Vila, A. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4459 · Cited by 41 · see citing works

Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor

de Bartolomeis, A., Tomasetti, C., Cicale, M., Yuan, P., & Manji, H. K. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.11.006 · Cited by 40 · see citing works

Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

Minabe, Y., Matsuno, K., & Ashby, C. R. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199908)33:2 · Cited by 40 · see citing works

Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal sub-regions

Iasevoli, F., Fiore, G., Cicale, M., Muscettola, G., & de Bartolomeis, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.02.009 · Cited by 39 · see citing works

A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia

Rizig, M., McQuillin, A., Ng, A., Robinson, M., Harrison, A., Zvelebil, M., Hunt, S., & Gurling, H. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112450780 · Cited by 39 · see citing works

Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain

Kim, H., Cheon, Y., Modi, H. R., Rapoport, S. I., & Rao, J. S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2671-7 · Cited by 39 · see citing works

Brain volume changes over the first year of treatment in schizophrenia: relationships to antipsychotic treatment

Emsley, R. A., Asmal, L., du Plessis, S., Chiliza, B., Phahladira, L. S., & Kilian, S. (2017) · Psychological Medicine · doi:10.1017/s0033291717000642 · Cited by 39 · see citing works

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al. (2018) · Science · doi:10.1126/science.aat8127 · Cited by 1,247 · see citing works

Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic

Yohn, S. E., Weiden, P. J., Felder, C. C., & Stahl, S. M. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.09.006 · Cited by 113 · see citing works

Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia

de Bartolomeis, A., Vellucci, L., Barone, A., Manchia, M., Luca, V. D., Iasevoli, F., & Correll, C. U. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108236 · Cited by 88 · see citing works

Present and future antipsychotic drugs: a systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective.

de Bartolomeis, A., Barone, A., Begni, V., & Riva, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106078 · Cited by 62 · see citing works

Treatment-Resistant to Antipsychotics: A Resistance to Everything? Psychotherapy in Treatment-Resistant Schizophrenia and Nonaffective Psychosis: A 25-Year Systematic Review and Exploratory Meta-Analysis

Polese, D., Fornaro, M., Palermo, M., Luca, V. D., & de Bartolomeis, A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00210 · Cited by 70 · see citing works

Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia

de Bartolomeis, A., Manchia, M., Marmo, F., Vellucci, L., Iasevoli, F., & Barone, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00369 · Cited by 43 · see citing works

Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress

Reshetnikov, V. V., Kisaretova, P. E., Ershov, N., Merkulova, T. I., & Bondar, N. P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110068 · Cited by 40 · see citing works

Towards Novel Treatments for Schizophrenia: Molecular and Behavioural Signatures of the Psychotropic Agent SEP-363856

Begni, V., Sanson, A., Luoni, A., Sensini, F., Grayson, B., Munni, S., Neill, J., & Riva, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084119 · Cited by 36 · see citing works

Glutamate in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia: A Meta-analysis of 1H-Magnetic Resonance Spectroscopy Studies

Kaminski, J. A., Mascarell-Maricic, L., Fukuda, Y., Katthagen, T., Heinz, A., & Schlagenhauf, F. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.09.001 · Cited by 31 · see citing works

Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin

de Azevedo, H. F. Z., Ferreira, M. A., Mascarello, A., Osten, P., & Guimarães, C. R. W. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100226 · Cited by 25 · see citing works

Canonical and Non-Canonical Antipsychotics’ Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia

de Bartolomeis, A., Ciccarelli, M., Simone, G. D., Mazza, B., Barone, A., & Vellucci, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065945 · Cited by 25 · see citing works

Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease

Waters, S., Sonesson, C., Svensson, P., Tedroff, J., Carta, M., Ljung, E., Gunnergren, J., Edling, M., Svanberg, B., Fagerberg, A., et al. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.264226 · Cited by 20 · see citing works

Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice

Tanqueiro, S. R., Mouro, F. M., Ferreira, C. B., Freitas, C. F., Fonseca‐Gomes, J., do Couto, F. S., Sebastião, A. M., Dawson, N., & Diógenes, M. J. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211008560 · Cited by 22 · see citing works

Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia.

de Bartolomeis, A., Avagliano, C., Vellucci, L., D'Ambrosio, L., Manchia, M., D'Urso, G., Buonaguro, E., & Iasevoli, F. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.019 · Cited by 17 · see citing works

Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins

Buonaguro, E. F., Morley‐Fletcher, S., Avagliano, C., Vellucci, L., Iasevoli, F., Bouwalerh, H., Camp, G. V., Nicoletti, F., Maccari, S., & de Bartolomeis, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109725 · Cited by 15 · see citing works

Low frequency repetitive transcranial magnetic stimulation promotes plasticity of the visual cortex in adult amblyopic rats

Zheng, J. J., Zhang, W., Liu, L., & Yap, M. K. H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1109735 · Cited by 14 · see citing works

Chronic treatment with the antipsychotic drug blonanserin modulates the responsiveness to acute stress with anatomical selectivity

Marchisella, F., Paladini, M. S., Guidi, A., Begni, V., Brivio, P., Spero, V., Calabrese, F., Molteni, R., & Riva, M. A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05498-9 · Cited by 13 · see citing works

Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage

Chen, T., Xu, Y.-P., Chen, Y., Sun, S., Yan, Z., & Wang, Y. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110780 · Cited by 13 · see citing works

Elevated brain-derived neurotrophic factor (BDNF) serum levels in an acute episode of schizophrenia in polish women: Correlation with clinical and metabolic parameters.

Skibińska, M., Kapelski, P., Rajewska‐Rager, A., Szczepankiewicz, A., Narożna, B., Duda, J., Budziński, B., Hauser, J., Dmitrzak‐Węglarz, M., & Pawlak, J. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.041 · Cited by 11 · see citing works

The Effect of Lithium Chloride on the Levels of Brain-Derived Neurotrophic Factor in the Neonatal Brain

Bannova, A. V., Menshanov, P. N., & Дыгало, Н. Н. (2019) · Neurochemical Journal · doi:10.1134/s1819712419030048 · Cited by 10 · see citing works

The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted

Iasevoli, F., Buonaguro, E., Avagliano, C., Barone, A., Eramo, A., Vellucci, L., & de Bartolomeis, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155555 · Cited by 11 · see citing works

Haloperidol-Induced Immediate Early Genes in Striatopallidal Neurons Requires the Converging Action of cAMP/PKA/DARPP-32 and mTOR Pathways

Onimus, O., Valjent, E., Fisone, G., & Gangarossa, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911637 · Cited by 8 · see citing works

Serial electroconvulsive Seizure alters dendritic complexity and promotes cellular proliferation in the mouse dentate gyrus; a role for Egr3

Meyers, K. T., Damphousse, C. C., Ozols, A. B., Campbell, J. M., Newbern, J. M., Hu, C., Marrone, D. F., & Gallitano, A. L. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.04.022 · Cited by 8 · see citing works

LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons

Chen, C., Masotti, M., Shepard, N., Promes, V., Tombesi, G., Arango, D., Manzoni, C., Greggio, E., Hilfiker, S., Kozorovitskiy, Y., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03030-z · Cited by 8 · see citing works

Glycine transporter type 1 (GlyT1) inhibition improves conspecific-provoked immobility in BALB/c mice: Analysis of corticosterone response and glucocorticoid gene expression in cortex and hippocampus

Burket, J. A., Pickle, J. C., Rusk, A., Haynes, B. A., Sharp, J. A., & Deutsch, S. I. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109869 · Cited by 8 · see citing works

A Case of Comorbid PTSD and Posttraumatic OCD Treated with Sertraline-Aripiprazole Augmentation

Rossi, R., Niolu, C., Siracusano, A., Rossi, A., & Lorenzo, G. D. (2020) · Case Reports in Psychiatry · doi:10.1155/2020/2616492 · Cited by 8 · see citing works

Mapping of c-Fos Expression in Rat Brain Sub/Regions Following Chronic Social Isolation: Effective Treatments of Olanzapine, Clozapine or Fluoxetine

Stanisavljević, A., & Filipović, D. (2024) · Pharmaceuticals · doi:10.3390/ph17111527 · Cited by 7 · see citing works

Advanced genetic and viral methods for labelling and manipulation of oxytocin and vasopressin neurones in rats

Yoshimura, M., & Ueta, Y. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2932-9 · Cited by 7 · see citing works

Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model

Iwakura, Y., Kawahara‐Miki, R., Kida, S., Sotoyama, H., Gabdulkhaev, R., Takahashi, H., Kunii, Y., Hino, M., Nagaoka, A., Izumi, R., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03599-9 · Cited by 7 · see citing works

Behavioral and transcriptional effects of repeated electroconvulsive seizures in the neonatal MK-801-treated rat model of schizophrenia

Lee, J., Huh, S., Park, K., Kang, N., Yu, H., Park, H. G., Kim, Y. S., Kang, U. G., Won, S., & Kim, S. H. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06511-7 · Cited by 6 · see citing works

Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia

Thériault, R.-K., St‐Denis, M., Hewitt, T., Khokhar, J. Y., Lalonde, J., & Perreault, M. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115511 · Cited by 5 · see citing works

Clozapine's Multiple Cellular Mechanisms: What Do We Know after More than Fifty Years? a Systematic Review and Critical Assessment of Translational Mechanisms Relevant for Innovative Strategies in Treatment-Resistant SchizophreniaPreprint

de Bartolomeis, A., Vellucci, L., Barone, A., Manchia, M., Luca, V. D., Iasevoli, F., & Correll, C. U. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4089530 · Cited by 4 · see citing works

Blockade of adenosine A2A receptors inhibits Tremulous Jaw Movements as well as expression of zif-268 and GAD65 mRNAs in brain motor structures

Kosmowska, B., Ossowska, K., & Wardas, J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113585 · Cited by 3 · see citing works

Antipsychotics and dietary interventions: Pharmacodynamics, pharmacokinetics, and synergisms in therapy

Perrotta, C., Carnovale, C., Pozzi, M., Palma, C. D., Cervia, D., Nobile, M., & Clementi, E. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100061 · Cited by 2 · see citing works

Effects of the Phosphodiesterase 10A Inhibitor MR1916 on Alcohol Self-Administration and Striatal Gene Expression in Post-Chronic Intermittent Ethanol-Exposed Rats

Bertotto, L. B., Lampson-Stixrud, D., Sinha, A., Rohani, N. K., Myer, I., & Zorrilla, E. P. (2024) · Cells · doi:10.3390/cells13040321 · Cited by 2 · see citing works

Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

Kiss, A., & Osacká, J. (2021) · Endocrine Regulations · doi:10.2478/enr-2021-0013 · Cited by 2 · see citing works

Medications for Psychosis: Dopamine Blockers and Dopamine Partial Agonists (Antipsychotics)

Uchida, H., Kim, E., Jarskog, L. F., Fleischhacker, W. W., Remington, G. J., & Lieberman, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_134-1 · Cited by 2 · see citing works

Striatal Nitric Oxide Activity Better Predicts Motor Disability Than Proto‐Oncogenes

Prieto, S. G., Silva, V. R. C. T. D., Almeida, M. C., & Echeverry, M. B. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70386 · Cited by 1 · see citing works

The Interplay Between Nurr1 and Mitochondrial Biogenesis: Implications for Neurodegenerative Therapy

Kaur, S., Mannan, A., & Singh, T. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05633-7 · Cited by 1 · see citing works

Medications for Psychosis: Dopamine Blockers and Dopamine Partial Agonists (Antipsychotics)

Uchida, H., Kim, E., Jarskog, L. F., Fleischhacker, W. W., Remington, G. J., & Lieberman, J. A. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_134

Research Progress on MECT Combined with Second-Generation Antipsychotic Drugs in the Treatment of Schizophrenia

杨, 堃. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.151117

Multiomics analysis of psychiatric/psychological disorder

Biswas, I., Senthilathiban, D. P., Kuduvalli, S. S., & Mariappan, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33351-4.00011-8

Clozapine's Molecular Signature: Selective 5‐ HT2A Receptor Downregulation and Signalling in Rat Brain Cortical Regions

Kędracka–Krok, S., Nowak, J., Fic, E., Solich, J., Rybczyński, P., Romanska, W., Sarga, P., Pustelny, K., & Dziedzicka‐Wasylewska, M. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70229

Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice

Ziemiańska, M., Zięba, M., Radlicka-Borysewska, A., Szumiec, Ł., Gołda, S., Borczyk, M., Piechota, M., Korostyński, M., & Parkitna, J. M. R. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1844705

Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT—PCR study

Robbins, M., Critchlow, H., Lloyd, A., Cilia, J., Clarke, J. D. W., Bond, B. C., Jones, D., & Maycox, P. R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107081521 · Cited by 37 · see citing works

Switching antipsychotics: how and where a prolonged treatment with a typical antipsychotic affects the topography of postsynaptic density gene expression induced by an atypical antipsychotic. Relevance for pychosis treatment.

Marmo, F. (2015) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/10507

Temporal and Spatial Transcriptional Fingerprints by Antipsychotic or Propsychotic Drugs in Mouse Brain

Sakuma, K., Komatsu, H., Maruyama, M., Imaichi, S., Habata, Y., & Mori, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118510 · Cited by 26 · see citing works

Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: Insights for psychosis treatment

de Bartolomeis, A., Iasevoli, F., Marmo, F., Buonaguro, E. F., Eramo, A., Rossi, R., Avvisati, L., Latte, G., & Tomasetti, C. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.003 · Cited by 32 · see citing works

Re-arrangements of gene transcripts at glutamatergic synapses after prolonged treatments with antipsychotics: A putative link with synaptic remodeling

Buonaguro, E. F., Iasevoli, F., Marmo, F., Eramo, A., Latte, G., Avagliano, C., Tomasetti, C., & de Bartolomeis, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.012 · Cited by 25 · see citing works