CoChat
Sign Up
Cited by 364Lymphoma Diagnosis and TreatmentCancer-related Molecular PathwaysGenomics and Chromatin Dynamics

c-Myc enhances protein synthesis and cell size during B lymphocyte development

Open access
Iritani, Brian M., Eisenman, Robert N.·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.23.13180PMC PMC23921
Open this paper in CoChat — free account

Abstract

Members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis. Moreover, inappropriate expression of c- myc genes contributes to the development of many types of cancers, including B cell lymphomas in humans. Although Myc proteins have been shown to function as transcription factors, their immediate effects on the cell have not been well defined. Here we have utilized a murine model of lymphomagenesis (Eμ- myc mice) to show that constitutive expression of a c- myc transgene under control of the Ig heavy-chain enhancer (Eμ) results in an increase in cell size of normal pretransformed B lymphocytes at all stages of B cell development. Furthermore, we show that c-Myc-induced growth occurs independently of cell cycle phase and correlates with an increase in protein synthesis. These results suggest that Myc may normally function by coordinating expression of growth-related genes in response to mitogenic signals. Deregulated c- myc expression may predispose to cancer by enhancing cell growth to levels required for unrestrained cell division.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.96.23.13180

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 62

  1. [1]Killander D, Zetterberg A. Exp Cell Res. 1965;38:272–284. doi: 10.1016/0014-4827(65)90403-9. [DOI] [PubMed] [Google Scholar] · DOI
  2. [2]Neufeld T P, Edgar B A. Curr Opin Cell Biol. 1998;10:784–790. doi: 10.1016/s0955-0674(98)80122-1. [DOI] [PubMed] [Google Scholar] · DOI
  3. [3]Blackwood E M, Eisenman R N. Science. 1991;251:1211–1217. doi: 10.1126/science.2006410. [DOI] [PubMed] [Google Scholar] · DOI
  4. [5]Kretzner L, Blackwood E M, Eisenman R N. Nature (London) 1992;359:426–429. doi: 10.1038/359426a0. [DOI] [PubMed] [Google Scholar] · DOI
  5. [6]Amati B, Dalton S, Brooks M W, Littlewood T D, Evan G I, Land H. Nature (London) 1992;359:423–426. doi: 10.1038/359423a0. [DOI] [PubMed] [Google Scholar] · DOI
  6. [7]Li L, Nerlov K, Prendergast G, MacGregor D, Ziff E B. EMBO J. 1994;13:4070–4079. doi: 10.1002/j.1460-2075.1994.tb06724.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  7. [8]Spencer C A, Groudine M. Adv Cancer Res. 1991;56:1–48. doi: 10.1016/s0065-230x(08)60476-5. [DOI] [PubMed] [Google Scholar] · DOI
  8. [9]West M J, Stoneley M, Willis A E. Oncogene. 1998;17:769–780. doi: 10.1038/sj.onc.1201990. [DOI] [PubMed] [Google Scholar] · DOI
  9. [10]Salghetti S E, Kim S Y, Tansey W P. EMBO J. 1999;18:717–726. doi: 10.1093/emboj/18.3.717. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  10. [11]Sears R, Leone G, DeGregori J, Nevins J R. Mol Cell. 1999;3:169–179. doi: 10.1016/s1097-2765(00)80308-1. [DOI] [PubMed] [Google Scholar] · DOI
  11. [12]Kelly K, Cochran B H, Stiles C D, Leder P. Cell. 1983;35:603–610. doi: 10.1016/0092-8674(83)90092-2. [DOI] [PubMed] [Google Scholar] · DOI
  12. [13]Campisi J, Gray H E, Pardee A B, Dean M, Sonenshein G. Cell. 1984;36:241–247. doi: 10.1016/0092-8674(84)90217-4. [DOI] [PubMed] [Google Scholar] · DOI
  13. [14]Greenberg M E, Ziff E B. Nature (London) 1984;311:433–438. doi: 10.1038/311433a0. [DOI] [PubMed] [Google Scholar] · DOI
  14. [15]Hann S R, Thompson C B, Eisenman R N. Nature (London) 1985;314:366–369. doi: 10.1038/314366a0. [DOI] [PubMed] [Google Scholar] · DOI
  15. [16]Waters C M, Littlewood T D, Hancock D C, Moore J P, Evan G I. Oncogene. 1991;6:797–805. [PubMed] [Google Scholar]
  16. [17]Palmieri S, Kahn P, Graf T. EMBO J. 1983;2:2385–2389. doi: 10.1002/j.1460-2075.1983.tb01750.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  17. [18]Stern D, Roberts A, Roche N S, Sporn M B, Weinberg R A. Mol Cell Biol. 1986;6:870–877. doi: 10.1128/mcb.6.3.870-877.1986. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  18. [19]Karn J, Watson J V, Lowe A D, Green S M, Vedeckis W. Oncogene. 1989;4:773–787. [PubMed] [Google Scholar]
  19. [20]Eilers M, Schirm S, Bishop J M. EMBO J. 1991;10:133–141. doi: 10.1002/j.1460-2075.1991.tb07929.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  20. [21]Roussel M F, Cleveland J L, Shurtleff S A, Sherr C J. Nature (London) 1991;353:361–363. doi: 10.1038/353361a0. [DOI] [PubMed] [Google Scholar] · DOI
  21. [22]Mateyak M K, Obaya A J, Adachi S, Sedivy J M. Cell Growth Differ. 1997;8:1039–1048. [PubMed] [Google Scholar]
  22. [23]Henriksson M, Luscher B. Adv Cancer Res. 1996;68:109–182. doi: 10.1016/s0065-230x(08)60353-x. [DOI] [PubMed] [Google Scholar] · DOI
  23. [24]Grandori C, Eisenman R N. Trends Biochem Sci. 1997;22:177–181. doi: 10.1016/s0968-0004(97)01025-6. [DOI] [PubMed] [Google Scholar] · DOI
  24. [25]Dang C V. Mol Cell Biol. 1999;19:1–11. doi: 10.1128/mcb.19.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  25. [26]Cory S. Adv Cancer Res. 1986;47:189–234. doi: 10.1016/s0065-230x(08)60200-6. [DOI] [PubMed] [Google Scholar] · DOI
  26. [27]Magrath I. Adv Cancer Res. 1990;55:134–251. doi: 10.1016/s0065-230x(08)60470-4. [DOI] [PubMed] [Google Scholar] · DOI
  27. [28]Tonini G P. In: Encyclopedia of Cancer. Bertino J R, editor. San Diego: Academic; 1997. pp. 1212–1239. [Google Scholar]
  28. [29]McCormack S J, Lippman M E, Dickson R B. In: Encyclopedia of Cancer. Bertino J R, editor. San Diego: Academic; 1997. pp. 165–172. [Google Scholar]
  29. [30]Adams J M, Harris A W, Pinkert C A, Corcoran L M, Alexander W S, Cory S, Palmiter R D, Brinster R L. Nature (London) 1985;318:533–538. doi: 10.1038/318533a0. [DOI] [PubMed] [Google Scholar] · DOI
  30. [31]Cory S, Adams J. Ann Rev Immunol. 1988;6:25–48. doi: 10.1146/annurev.iy.06.040188.000325. [DOI] [PubMed] [Google Scholar] · DOI
  31. [32]Langdon W Y, Harris A W, Cory S, Adams J M. Cell. 1986;47:11–18. doi: 10.1016/0092-8674(86)90361-2. [DOI] [PubMed] [Google Scholar] · DOI
  32. [33]van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A. Cell. 1989;56:673–682. doi: 10.1016/0092-8674(89)90589-8. [DOI] [PubMed] [Google Scholar] · DOI
  33. [34]Rosenbaum H, Harris A W, Bath M L, McNeall J, Webb E, Adams J M, Cory S. EMBO J. 1990;9:897–905. doi: 10.1002/j.1460-2075.1990.tb08187.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  34. [35]van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Cell. 1991;65:737–752. doi: 10.1016/0092-8674(91)90382-9. [DOI] [PubMed] [Google Scholar] · DOI
  35. [36]Haupt Y, Alexander W S, Barri G, Klinken S P, Adams J M. Cell. 1991;65:753–763. doi: 10.1016/0092-8674(91)90383-a. [DOI] [PubMed] [Google Scholar] · DOI
  36. [37]Haupt Y, Harris A W, Adams J M. Oncogene. 1992;7:981–986. [PubMed] [Google Scholar]
  37. [38]Bodrug S E, Warner B J, Bath M L, Lindemann G J, Harris A W, Adams J M. EMBO J. 1994;13:2124–2130. doi: 10.1002/j.1460-2075.1994.tb06488.x. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  38. [39]Downs K M, Martin G R, Bishop J M. Genes Dev. 1989;3:860–869. doi: 10.1101/gad.3.6.860. [DOI] [PubMed] [Google Scholar] · DOI
  39. [40]Craig R W, Buchan H L, Civin C I, Kastan M B. Cell Growth Differ. 1993;4:349–357. [PubMed] [Google Scholar]
  40. [41]Wakamatsu Y, Watanabe Y, Shimono A, Kondoh H. Neuron. 1993;10:1–9. doi: 10.1016/0896-6273(93)90236-k. [DOI] [PubMed] [Google Scholar] · DOI
  41. [42]Davis A C, Wims M, Spotts G D, Hann S R, Bradley A. Genes Dev. 1993;7:671–682. doi: 10.1101/gad.7.4.671. [DOI] [PubMed] [Google Scholar] · DOI
  42. [43]Stanton B R, Perkins A S, Tessarollo L, Sassoon D A, Parada L F. Genes Dev. 1993;6:2235–2247. doi: 10.1101/gad.6.12a.2235. [DOI] [PubMed] [Google Scholar] · DOI
  43. [44]Johnston L A, Prober D A, Edgar B A, Eisenman R N, Gallant P. Cell. 1999;98:779–790. doi: 10.1016/s0092-8674(00)81512-3. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  44. [45]Iritani B M, Forbush K A, Farrar M A, Perlmutter R M. EMBO J. 1997;16:7019–7031. doi: 10.1093/emboj/16.23.7019. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  45. [46]Mishell R I, Shiigi S M. Selected Methods in Cellular Immunology. San Francisco: Freeman; 1980. [Google Scholar]
  46. [47]Said S, Tamura T, Gerdes A M. BioTechniques. 1998;25:522–525. doi: 10.2144/98253pf02. [DOI] [PubMed] [Google Scholar] · DOI
  47. [48]Laherty C D, Yang W-M, Sun J-M, Davie J R, Seto E, Eisenman R N. Cell. 1997;89:349–356. doi: 10.1016/s0092-8674(00)80215-9. [DOI] [PubMed] [Google Scholar] · DOI
  48. [49]Blackwood E M, Luscher B, Eisenman R N. Genes Dev. 1992;6:71–80. doi: 10.1101/gad.6.1.71. [DOI] [PubMed] [Google Scholar] · DOI
  49. [50]Vaux D L, Adams J M, Alexander W S, Pike B L. J Immunol. 1987;139:3854–3860. [PubMed] [Google Scholar]
  50. [51]Harris A W, Pinkert C A, Crawford M, Langdon W Y, Brinster R L, Adams J M. J Exp Med. 1988;167:353–371. doi: 10.1084/jem.167.2.353. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  51. [52]Langdon W Y, Harris A W, Cory S. Oncogene Res. 1988;3:271–279. [PubMed] [Google Scholar]
  52. [53]Hann S R, Eisenman R N. Mol Cell Biol. 1984;4:2486–2497. doi: 10.1128/mcb.4.11.2486-2497.1984. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  53. [54]Hardy R R, Carmack C E, Shinton S A, Kemp J D, Hayakawa K. J Exp Med. 1991;173:1213–1225. doi: 10.1084/jem.173.5.1213. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  54. [55]Askew D, Ashmun R, Simmons B, Cleveland J. Oncogene. 1991;6:1915–1922. [PubMed] [Google Scholar]
  55. [56]Hartwell L H. J Mol Biol. 1971;14:183–194. doi: 10.1016/0022-2836(71)90420-7. [DOI] [PubMed] [Google Scholar] · DOI
  56. [57]Nurse P, Thuriaux P, Nasmyth K 1, Nasmyth K 1. Mol Gen Genet. 1976;146:167–178. doi: 10.1007/BF00268085. [DOI] [PubMed] [Google Scholar] · DOI
  57. [58]Johnston G C, Pringle J R, Hartwell L H. Exp Cell Res. 1977;105:79–98. doi: 10.1016/0014-4827(77)90154-9. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  58. [59]Swat W, Shinkai Y, Cheng H L, Davidson L, Alt F W. Proc Natl Acad Sci USA. 1996;93:4683–4687. doi: 10.1073/pnas.93.10.4683. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  59. [60]Iritani B M, Alberola-Ila J, Forbush K A, Perlmutter R M. Immunity. 1999;10:713–722. doi: 10.1016/s1074-7613(00)80070-9. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  60. [61]Melchers F. Curr Top Microbiol Immunol. 1997;224:19–30. doi: 10.1007/978-3-642-60801-8_2. [DOI] [PubMed] [Google Scholar] · DOI
  61. [62]Wu K-J, Polack A, Dalla-Favera R. Science. 1999;283:676–679. doi: 10.1126/science.283.5402.676. [DOI] [PubMed] [Google Scholar] · DOI
  62. [63]Polymenis M, Schmidt E V. Curr Opin Genet Dev. 1999;9:76–80. doi: 10.1016/s0959-437x(99)80011-2. [DOI] [PubMed] [Google Scholar] · DOI

Cited by

Sorted by citations

Authors
Iritani, B. M., & Eisenman, R. N.
Affiliations
Fred Hutch Cancer Center (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1999-11-09
Volume
96
Issue
23
Pages
13180-13185
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.23.13180
PMC
PMC23921
OpenAlex
W2040803520
Cited by
364
References
1
Citations by year
2026: 4 · 2025: 8 · 2024: 17 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 12 · 2015: 10 · 2014: 17 · 2013: 10 · 2012: 10
FWCI
14.22
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (1 K08 AJ01445-01)
  • National Heart, Lung, and Blood Institute (P50HL054881, HL54881)
  • National Cancer Institute (R01CA020525, R01-CA20525)
  • National Institute of Allergy and Infectious Diseases (K08AI001445)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
c-Myc, B cell development, protein synthesis, cell size, lymphomagenesis, proto-oncogenes, cell growth, mitogenic signaling, B-cell lymphoma
MeSH terms
Animals, B-Lymphocytes, Cell Cycle, Mice, Inbred C57BL, Mice, Transgenic, Proto-Oncogene Proteins c-myc, Transgenes, Cell Size, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review