The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
Open accessAbstract
Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGFβ) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to assess potential later roles in creation of the heart. Here, we used a Cre/lox system for cardiac myocyte-specific deletion of the type IA BMP receptor, ALK3. ALK3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK3 was specifically deficient in expressing TGFβ2, an established paracrine mediator of cushion morphogenesis. Hence, ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis.
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Citations
Cites
Incidence of congenital heart disease: I. Postnatal incidence
Hoffman, J. I. E. (1995) · Pediatric Cardiology · doi:10.1007/bf00801907 · Cited by 786
Cited by
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Oh, H., Bradfute, S. B., Gallardo, T. D., Nakamura, T., Gaussin, V., Mishina, Y., Pocius, J., Michael, L. H., Behringer, R. R., Garry, D. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132126100 · Cited by 1,743
Self-citationGenetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Chang, H., Brown, C. W., & Matzuk, M. M. (2002) · Endocrine Reviews · doi:10.1210/er.2002-0003 · Cited by 787
Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis
Fang, X., Cai, Z., Wang, H., Han, D., Cheng, Q., Zhang, P., Gao, F., Yu, Y., Song, Z., Wu, Q., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316509 · Cited by 770
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
Ma, L., Lu, M.-F., Schwartz, R. J., & Martin, J. F. (2005) · Development · doi:10.1242/dev.02156 · Cited by 525
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
Chen, H., Shi, S., Acosta, L., Li, W., Lu, J., Bao, S., Chen, Z., Yang, Z., Schneider, M. D., Chien, K. R., et al. (2004) · Development · doi:10.1242/dev.01094 · Cited by 521
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Metadata
- Authors
- Gaussin, V., Van de Putte, T., Mishina, Y., Hanks, M. C., Zwijsen, A., Huylebroeck, D., Behringer, R. R., & Schneider, M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 5
- Pages
- 2878-2883
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038629624
- Cited by
- 283
- References
- 1
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Gaussin, V., Van de Putte, T., Mishina, Y., Hanks, M. C., Zwijsen, A., Huylebroeck, D., Behringer, R. R., & Schneider, M. D. (2002). Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.042390499
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