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Cited by 107Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulationNeurobiology and Insect Physiology Research

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Differential patterns of apoptosis in response to aging in Drosophila

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Zheng, Jie, Edelman, Scott W., Tharmarajah, Grace, Walker, David W., Pletcher, Scott D., Seroude, Laurent·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0503374102PMC PMC1189317
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Abstract

Several lines of evidence suggest that programmed cell death may play a role in the aging process and the age-related functional declines of multicellular organisms. To pave the way for the use of Drosophila to rigorously test this hypothesis in a genetic model organism, this work examines the pattern of apoptosis in the adult fly during aging. The analysis across the lifespan of caspase activity and DNA fragmentation shows that apoptosis occurs in adult flies at all ages and that it is linked to physiological age. The results establish that under normal conditions, fly aging is coupled with a lifelong gradual increase of apoptosis within muscle cells and an activation of apoptosis in fat cells of old flies. The nervous system does not show signs of apoptosis. These time- and tissue-specific changes indicate that aging influences the levels and the nature of the cells that commit to apoptosis. The comparison with the apoptotic response to starvation and oxidative stresses strongly suggests that the lifelong increase in flight and leg muscles results from the accumulation of oxidative damage associated with aging. This finding presents an attractive mechanism to account for the decline of locomotor functions and muscle loss in the elderly and opens the way for the genetic analysis of sarcopenia in Drosophila.

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Crossref · 10.1073/pnas.0503374102

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Research works printed but not linked: 5

  1. Miquel, J. (1971) Adv. Gerontol. Res. 3, 39–71.4329201
  2. Tornusciolo, D. R., Schmidt, R. E. & Roth, K. A. (1995) BioTechniques 19, 800–805.8588920
  3. Robinow, S., Talbot, W. S., Hogness, D. S. & Truman, J. W. (1993) Development (Cambridge, U.K.) 119, 1251–1259.
  4. Elens, A. (1972) Drosophila Information Service 48, 108.
  5. Phillips, T. & Leeuwenburgh, C. (2005) FASEB J. 19, 668–670.15665035

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Metadata

Authors
Zheng, J., Edelman, S. W., Tharmarajah, G., Walker, D. W., Pletcher, S. D., & Seroude, L.
Affiliations
California Institute of Technology (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2005-08-12
Volume
102
Issue
34
Pages
12083-12088
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0503374102
PMC
PMC1189317
OpenAlex
W2137068591
Cited by
100
References
53
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 3
FWCI
1.57
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders
  • Queen's University
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
apoptosis, aging, Drosophila, caspase activity, DNA fragmentation, muscle cells, adipocytes, nervous system, oxidative stress, starvation, sarcopenia, tissue-specific aging
MeSH terms
Adipose Tissue, Age Factors, Aging, Animals, Drosophila, Muscles, Apoptosis, DNA Primers, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Caspases, In Situ Nick-End Labeling, DNA Fragmentation

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