Cited by 107Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulationNeurobiology and Insect Physiology Research

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Differential patterns of apoptosis in response to aging in Drosophila

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Zheng, Jie, Edelman, Scott W., Tharmarajah, Grace, Walker, David W., Pletcher, Scott D., Seroude, Laurent·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0503374102PMC PMC1189317

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Abstract

Several lines of evidence suggest that programmed cell death may play a role in the aging process and the age-related functional declines of multicellular organisms. To pave the way for the use of Drosophila to rigorously test this hypothesis in a genetic model organism, this work examines the pattern of apoptosis in the adult fly during aging. The analysis across the lifespan of caspase activity and DNA fragmentation shows that apoptosis occurs in adult flies at all ages and that it is linked to physiological age. The results establish that under normal conditions, fly aging is coupled with a lifelong gradual increase of apoptosis within muscle cells and an activation of apoptosis in fat cells of old flies. The nervous system does not show signs of apoptosis. These time- and tissue-specific changes indicate that aging influences the levels and the nature of the cells that commit to apoptosis. The comparison with the apoptotic response to starvation and oxidative stresses strongly suggests that the lifelong increase in flight and leg muscles results from the accumulation of oxidative damage associated with aging. This finding presents an attractive mechanism to account for the decline of locomotor functions and muscle loss in the elderly and opens the way for the genetic analysis of sarcopenia in Drosophila.

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Additional file 6 of Aging features of the migratory locust at physiological and transcriptional levels
Guo, S., Yang, P., Liang, B., Zhou, F., Hou, L., Kang, L., & Wang, X. (2021) · Figshare · doi:10.6084/m9.figshare.14398369
Additional file 8 of Aging features of the migratory locust at physiological and transcriptional levels
Guo, S., Yang, P., Liang, B., Zhou, F., Hou, L., Kang, L., & Wang, X. (2021) · Figshare · doi:10.6084/m9.figshare.14398375
Additional file 2 of Aging features of the migratory locust at physiological and transcriptional levels
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Additional file 3 of Aging features of the migratory locust at physiological and transcriptional levels
Guo, S., Yang, P., Liang, B., Zhou, F., Hou, L., Kang, L., & Wang, X. (2021) · Figshare · doi:10.6084/m9.figshare.14398360

Authors: Zheng, J., Edelman, S. W., Tharmarajah, G., Walker, D. W., Pletcher, S. D., & Seroude, L.
Affiliations: California Institute of Technology (US)
ORCID: Zheng, Jie
Walker, David W.
Pletcher, Scott D.
Seroude, Laurent
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-08-12
Volume: 102
Issue: 34
Pages: 12083-12088
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0503374102
PMC: PMC1189317
OpenAlex: W2137068591
Cited by: 100
References: 53
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 3
FWCI: 1.57
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: Queen's University
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: apoptosis, aging, Drosophila, caspase activity, DNA fragmentation, muscle cells, adipocytes, nervous system, oxidative stress, starvation, sarcopenia, tissue-specific aging
MeSH terms: Adipose Tissue, Age Factors, Aging, Animals, Drosophila, Muscles, Apoptosis, DNA Primers, Oxidative Stress, Reverse Transcriptase Polymerase Chain Reaction, Caspases, In Situ Nick-End Labeling, DNA Fragmentation

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Differential patterns of apoptosis in response to aging in Drosophila

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