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Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI
Open accessAbstract
The brain acts as an integrated information processing system, which methods in cognitive neuroscience have so far depicted in a fragmented fashion. Here, we propose a simple and robust way to integrate functional MRI (fMRI) with single trial event-related potentials (ERP) to provide a more complete spatiotemporal characterization of evoked responses in the human brain. The idea behind the approach is to find brain regions whose fMRI responses can be predicted by paradigm-induced amplitude modulations of simultaneously acquired single trial ERPs. The method was used to study a variant of a two-stimulus auditory target detection (odd-ball) paradigm that manipulated predictability through alternations of stimulus sequences with random or regular target-to-target intervals. In addition to electrophysiologic and hemodynamic evoked responses to auditory targets per se , single-trial modulations were expressed during the latencies of the P2 (170-ms), N2 (200-ms), and P3 (320-ms) components and predicted spatially separated fMRI activation patterns. These spatiotemporal matches, i.e., the prediction of hemodynamic activation by time-variant information from single trial ERPs, permit inferences about regional responses using fMRI with the temporal resolution provided by electrophysiology.
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“Moreover, for event-like tasks or stimuli, EEG features may also be extracted from temporal variations in single-trial potentials, and their correlations with fMRI reveal rich temporal dynamics of information processing in task-evoked neural networks (176, 177).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [176]
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Metadata
- Authors
- Eichele, T., Specht, K., Moosmann, M., Jongsma, M. L. A., Quiroga, R. Q., Nordby, H., & Hugdahl, K.
- Affiliations
- Radboud University Nijmegen (NL)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-11-28
- Volume
- 102
- Issue
- 49
- Pages
- 17798-17803
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1295592
- OpenAlex
- W2130038497
- Cited by
- 308
- References
- 59
- Citations by year
- 2026: 5 · 2025: 8 · 2023: 4 · 2022: 13 · 2021: 6 · 2020: 2 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 15 · 2015: 12 · 2014: 19 · 2013: 24 · 2012: 26
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Norges Forskningsråd
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- single-trial event-related potentials, functional MRI, spatiotemporal integration, evoked potentials, oddball paradigm, auditory target detection, predictability, P2 component, N2 component, P300
- MeSH terms
- Adult, Brain, Electroencephalography, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Neurons, Time Factors
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