The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes
Abstract
The mechanisms regulating activation of monocytes remain incompletely understood. Herein we provide evidence that Kruppel-like factor 2 (KLF2) inhibits proinflammatory activation of monocytes. In vitro , KLF2 expression in monocytes is reduced by cytokine activation or differentiation. Consistent with this observation, KLF2 expression in circulating monocytes is reduced in patients with chronic inflammatory conditions such as coronary artery disease. Adenoviral overexpression of KLF2 inhibits the LPS-mediated induction of proinflammatory factors, cytokines, and chemokines and reduces phagocytosis. Conversely, short interfering RNA-mediated reduction in KLF2 increased inflammatory gene expression. Reconstitution of immunodeficient mice with KLF2-overexpressing monocytes significantly reduced carrageenan-induced acute paw edema formation. Mechanistically, KLF2 inhibits the transcriptional activity of both NF-κB and activator protein 1, in part by means of recruitment of transcriptional coactivator p300/CBP-associated factor. These observations identify KLF2 as a novel negative regulator of monocytic activation.
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Cites
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KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
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Self-citationLethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
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Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016
Mammalian Krüppel-Like Factors in Health and Diseases
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Krüppel-like factor 4 regulates macrophage polarization
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Self-citationMacrophage phenotypes in atherosclerosis
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Kumar, V., Ramnarayanan, K., Sundar, R., Padmanabhan, N., Srivastava, S., Koiwa, M., Yasuda, T., Koh, V., Huang, K. K., Tay, S. T., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0683 · Cited by 573
Metadata
- Authors
- Das, H., Kumar, A., Lin, Z., Patino, W. D., Hwang, P. M., Feinberg, M. W., Majumder, P. K., & Jain, M. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-04-25
- Volume
- 103
- Issue
- 17
- Pages
- 6653-6658
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2099300133
- Cited by
- 305
- References
- 29
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Das, H., Kumar, A., Lin, Z., Patino, W. D., Hwang, P. M., Feinberg, M. W., Majumder, P. K., & Jain, M. K. (2006). Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0508235103
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