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Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
Abstract
A method is presented for measuring the edema induced by injection of 0.05 ml of 1% solution of carrageenin, an extract of Chondrus, into the plantar tissues of the hind paw of the rat. Peak edema develops within the first 3 to 4 hours, and is inhibited by pretreatment of the animals by single oral doses of antiinflammatory agents, steroid or non-steroid. Log dose responses to drugs are linear and parallel, and yield potency ratios with relatively narrow confidence limits. The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease. A potent antihistaminic-antiserotonin compound, cyproheptadine, is without effect on carrageenin-induced edema.
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Citations
Cited by
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Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656
Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00234-4 · Cited by 395
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Hajhashemi, V., Ghannadi, A., & Jafarabadi, H. (2004) · Phytotherapy Research · doi:10.1002/ptr.1390 · Cited by 365
COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease
Willoughby, D. A., Moore, A. R., & Colville-Nash, P. R. (2000) · The Lancet · doi:10.1016/s0140-6736(99)12031-2 · Cited by 298
Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289
Metadata
- Authors
- Winter, C. A., Risley, E. A., & Nuss, G. W.
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 1962-12-01
- Volume
- 111
- Issue
- 3
- Pages
- 544-547
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W1981819970
- Cited by
- 5,688
- References
- 0
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Winter, C. A., Risley, E. A., & Nuss, G. W. (1962). Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs. Experimental Biology and Medicine. https://doi.org/10.3181/00379727-111-27849
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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