The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cortisol levels and very early pregnancy loss in humans
Abstract
Maternal stress is commonly cited as an important risk factor for spontaneous abortion. For humans, however, there is little physiological evidence linking miscarriage to stress. This lack of evidence may be attributable to a paucity of research on maternal stress during the earliest gestational stages. Most human studies have focused on “clinical” pregnancy (>6 weeks after the last menstrual period). The majority of miscarriages, however, occur earlier, within the first 3 weeks after conception (≈5 weeks after the last menstrual period). Studies focused on clinical pregnancy thus miss the most critical period for pregnancy continuance. We examined the association between miscarriage and levels of maternal urinary cortisol during the first 3 weeks after conception. Pregnancies characterized by increased maternal cortisol during this period (within participant analyses) were more likely to result in spontaneous abortion ( P < 0.05). This evidence links increased levels in this stress marker with a higher risk of early pregnancy loss in humans.
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Cites
Incidence of early loss of pregnancy
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Time of Implantation of the Conceptus and Loss of Pregnancy
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Placental oxidative stress: from miscarriage to preeclampsia
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Childhood Stress and Family Environment
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Self-citationUsing the ratio of urinary oestrogen and progesterone metabolites to estimate day of ovulation
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Psychologic Stress in the Workplace and Spontaneous Abortion
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Self-reported stress and reproductive health of female lawyers
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Ellis (2009) · doi:10.1007/s12110-009-9063-7 · Cited by 1,592
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Prenatal stress and risk for autism
KINNEY, D., MUNIR, K., CROWLEY, D., & MILLER, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.004 · Cited by 440
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420
The Effect of Maternal Stress on Birth Outcomes: Exploiting a Natural Experiment
Torche, F. (2011) · Demography · doi:10.1007/s13524-011-0054-z · Cited by 351
Metadata
- Authors
- Nepomnaschy, P. A., Welch, K. B., McConnell, D. S., Low, B. S., Strassmann, B. I., & England, B. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-02-22
- Volume
- 103
- Issue
- 10
- Pages
- 3938-3942
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111450349
- Cited by
- 335
- References
- 9
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nepomnaschy, P. A., Welch, K. B., McConnell, D. S., Low, B. S., Strassmann, B. I., & England, B. G. (2006). Cortisol levels and very early pregnancy loss in humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0511183103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
