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Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
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Immune cells are exposed to low oxygen tensions as they develop and migrate between blood and different tissues, but the mechanisms by which lymphocytes adapt to hypoxia are poorly understood. Studies reported here of hypoxia-inducible factor 1α (HIF-1α) in lymphocyte development and functions suggest that it has a critical role in regulation of these processes. HIF-1α deficiency in Hif1α −/− → Rag2 −/− chimeric mice results in dramatic and cell lineage-specific defects, which include appearance of abnormal peritoneal B-1-like lymphocytes, with high expression of B220 (CD45) receptor-associated protein tyrosine phosphatase and autoimmunity (accumulation of anti-dsDNA antibodies and rheumatoid factor in serum, deposits of IgG and IgM in kidney and proteinuria) as well as distortions of maturation of B-2 lymphocytes in bone marrow.
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“and the first in vivo genetic evidence that hypoxia is immunosuppressive for T and B cells of the adaptive immune system (37).”
From Targeting HIF-1α abrogates PD-L1–mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues (2022) · cites this paper as [37]
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Cites
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Self-citationAbnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,162
Self-citationRole of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Self-citationCellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citationHIF-1: mediator of physiological and pathophysiological responses to hypoxia
Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822
Self-citationResolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,604
HIF‐1α is required for solid tumor formation and embryonic vascularization
Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579
Murine Models of Systemic Lupus Erythematosus
Theofilopoulos, A. N., & Dixon, F. J. (1985) · Advances in immunology · doi:10.1016/s0065-2776(08)60342-9 · Cited by 1,553
(2000) · PubMed · Cited by 1,445
Self-citationAnderson, P. C. (1999) · JAMA · doi:10.1001/jama.281.24.2351 · Cited by 1,013
Research works printed but not linked: 2
- G Key, M H Becker, B Baron, M Duchrow, C Schluter, D Flad, J Gerdes Lab Invest 68, 629–636 (1993).
- H Zhong, K Chiles, D Feldser, E Laughner, C Hanrahan, M M Georgescu, J W Simons, G L Semenza Cancer Res 60, 1541–1545 (2000).
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Self-citationEltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061
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Self-citationJung, Y., Isaacs, J. S., Lee, S., Trepel, J. B., & Neckers, L. (2003) · The FASEB Journal · doi:10.1096/fj.03-0329fje · Cited by 696
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Self-citationSamanta, D., Park, Y., Ni, X., Li, H., Zahnow, C. A., Gabrielson, E., Pan, F., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718197115 · Cited by 302
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Sitkovsky, M. V., Kjaergaard, J., Lukashev, D., & Ohta, A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0229 · Cited by 253
Self-citationInfection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs
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Sitkovsky, M. V., Hatfield, S., Abbott, R., Belikoff, B., Lukashev, D., & Ohta, A. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0075 · Cited by 215
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Thiel, M., Caldwell, C. C., Kreth, S., Kuboki, S., Chen, P., Smith, P., Ohta, A., Lentsch, A. B., Lukashev, D., & Sitkovsky, M. V. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000853 · Cited by 175
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Self-citationConforti, L., Petrovic, M., Mohammad, D., Lee, S., Ma, Q., Barone, S., & Filipovich, A. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.695 · Cited by 118
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Yang, M., Ma, C., Liu, S., Shao, Q., Gao, W., Song, B., Sun, J., Xie, Q., Zhang, Y., Feng, A., et al. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.77 · Cited by 110
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Jantsch, J., Wiese, M., Schödel, J., Castiglione, K., Gläsner, J., Kolbe, S., Mole, D., Schleicher, U., Eckardt, K.-U., Hensel, M., et al. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1210683 · Cited by 108
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García-Hernández, M. D. L. L., Gray, A., Hubby, B., & Kast, W. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2996 · Cited by 105
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Self-citationRekvig, O., & Nossent, J. C. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10739 · Cited by 101
Kojima, H., Kobayashi, A., Sakurai, D., Kanno, Y., Hase, H., Takahashi, R., Totsuka, Y., Semenza, G. L., Sitkovsky, M. V., & Kobata, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800167 · Cited by 99
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Rodríguez‐Vita, J., & Lawrence, T. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.006 · Cited by 83
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Wahl, D., Petersen, B., Warner, R. E., Richardson, B. C., Glick, G. D., & Opipari, A. (2010) · Lupus · doi:10.1177/0961203310373109 · Cited by 83
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Kapitsinou, P. P., & Haase, V. H. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00224.2015 · Cited by 81
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Rama, I., Brüne, B., Torrás, J., Koehl, R., Cruzado, J. M., Bestard, O., Franquesa, M., Lloberas, N., Weigert, A., Herrero, I., et al. (2008) · Kidney International · doi:10.1038/sj.ki.5002792 · Cited by 80
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Self-citationGene expression of the liver in response to chronic hypoxia
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Nagle, D. G., & Zhou, Y. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698783 · Cited by 68
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Johnson, M. O., Siska, P. J., Contreras, D. C., & Rathmell, J. C. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.09.003 · Cited by 74
Hypoxia: a double-edged sword of immunity
Sica, A., Melillo, G., & Varesio, L. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0724-8 · Cited by 66
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Metadata
- Authors
- Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V.
- Affiliations
- Dokkyo University (JP)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 4
- Pages
- 2170-2174
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC122337
- OpenAlex
- W2011846070
- Cited by
- 224
- References
- 26
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 13 · 2015: 10 · 2014: 9 · 2013: 7 · 2012: 13
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- hypoxia-inducible factor-1α, B cell development, autoimmunity, hypoxia, chimeric mice, Rag2-deficient mice, anti-dsDNA antibodies, rheumatoid factor, proteinuria, bone marrow, oxygen partial pressure
- MeSH terms
- Animals, B-Lymphocytes, Bone Marrow Cells, Cell Division, DNA-Binding Proteins, Flow Cytometry, Immunohistochemistry, Mice, Inbred C57BL, Mice, Transgenic, Time Factors, Transcription Factors, Autoimmunity, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
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