The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Mammalian monogamy is not controlled by a single gene
Open accessAbstract
Complex social behavior in Microtus voles and other mammals has been postulated to be under the direct genetic control of a single locus: the arginine vasopressin 1a receptor (avpr1a) gene. Using a phylogenetic approach, we show that a repetitive element in the promoter region of avpr1a, which reportedly causes social monogamy, is actually widespread in nonmonogamous Microtus and other rodents. There was no evidence for intraspecific polymorphism in regard to the presence or absence of the repetitive element. Among 25 rodent species studied, the element was absent in only two closely related nonmonogamous species, indicating that this absence is certainly the result of an evolutionarily recent loss. Our analyses further demonstrate that the repetitive structures upstream of the avpr1a gene in humans and primates, which have been associated with social bonding, are evolutionarily distinct from those in rodents. Our evolutionary approach reveals that monogamy in rodents is not controlled by a single polymorphism in the promoter region of the avpr1a gene. We thus resolve the contradiction between the claims for an evolutionarily conserved genetic programming of social behavior in mammals and the vast evidence for highly complex and flexible mating systems.
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“However, it is now known that length per se does not predict social organization of other Microtus species [29, 32], and sequence variation within the microsatellite may have a greater influence on expression than length itself [3].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [32]
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Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
Thompson, J. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.24.4876 · Cited by 38,685
Hall, T. A. (1999) · Nucleic Acids Symposium Series · doi:10.14601/phytopathol_mediterr-14998u1.29 · Cited by 38,156
PAUP^* : Phylogenetic Analysis Using Parsimony (and other methods) 4.0b8
Swofford, D. L. (2001) · Cited by 12,789
MEGA2: molecular evolutionary genetics analysis software
Kumar, S., Tamura, K., Jakobsen, I. B., & Nei, M. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.12.1244 · Cited by 6,046
Grau, J. M. G., & Sáiz‐Jiménez, C. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00362.x · Cited by 1,707
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Kleiman, D. G. (1977) · The Quarterly Review of Biology · doi:10.1086/409721 · Cited by 1,436
Inferring Coalescence Times From DNA Sequence Data
Tavaré, S., Balding, D. J., Griffiths, R., & Donnelly, P. (1997) · Genetics · doi:10.1093/genetics/145.2.505 · Cited by 941
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628
Research works printed but not linked: 2
- T. A. Hall Nucleic Acids Symp. Ser. 41, 95–98 (1999).
- N. Saitou, M. Nei Mol. Biol. Evol. 4, 406–425 (1987).
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Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Robinson, G. E., Fernald, R. D., & Clayton, D. F. (2008) · Science · doi:10.1126/science.1159277 · Cited by 595
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504
The prairie vole: An emerging model organism for understanding the social brain
McGraw, L. A., & Young, L. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.006 · Cited by 276
The biology of paternal care in human and nonhuman primates
Fernandez-Duque, E., Valeggia, C. R., & Mendoza, S. P. (2009) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-091908-164334 · Cited by 232
Metadata
- Authors
- Fink, S., Excoffier, L., & Heckel, G.
- Affiliations
- University of Bern (CH)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-07-18
- Volume
- 103
- Issue
- 29
- Pages
- 10956-10960
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1544156
- OpenAlex
- W2012695658
- Cited by
- 133
- References
- 40
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 12 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 18.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
- Keywords
- social monogamy, Microtus voles, social behavior genetics, gene loss, social bonding
- MeSH terms
- Animals, Humans, Molecular Sequence Data, Phylogeny, Rodentia, Sexual Behavior, Animal, Social Behavior, Receptors, Vasopressin, Cytochromes b
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