The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Redox sensor CtBP mediates hypoxia-induced tumor cell migration
Open accessAbstract
The rapid growth and poor vascularization of solid tumors expose cancer cells to hypoxia, which promotes the metastatic phenotype by reducing intercellular adhesion and increasing cell motility and invasiveness. In this study, we found that hypoxia increased free NADH levels in cancer cells, promoting CtBP recruitment to the E-cadherin promoter. This effect was blocked by pyruvate, which prevents the NADH increase. Furthermore, hypoxia repressed E-cadherin gene expression and increased tumor cell migration, effects that were blocked by CtBP knockdown. We propose that CtBP senses levels of free NADH to control expression of cell adhesion genes, thereby promoting tumor cell migration under hypoxic stress.
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Cites
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development · doi:10.1101/gad.14.1.34 · Cited by 967
Cited by
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P. E., Zhou, X., Li, C., Shen, G., & Zou, B. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00311-7 · Cited by 1,052
Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
Hung, Y. P., Albeck, J. G., Tantama, M., & Yellen, G. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.012 · Cited by 509
Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection
Zhao, Y., Jin, J., Hu, Q., Zhou, H.-M., Yi, J., Yu, Z., Xu, L., Wang, X., Yang, Y., & Loscalzo, J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.004 · Cited by 302
The Transcriptional Corepressor CtBP: A Foe of Multiple Tumor Suppressors
Chinnadurai, G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3349 · Cited by 264
RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
Zhang, Q., Wang, S.-Y., Fleuriel, C., Leprince, D., Rocheleau, J. V., Piston, D. W., & Goodman, R. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610590104 · Cited by 171
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Metadata
- Authors
- Zhang, Q., Wang, S.-Y., Nottke, A. C., Rocheleau, J. V., Piston, D. W., & Goodman, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-06-13
- Volume
- 103
- Issue
- 24
- Pages
- 9029-9033
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111365962
- Cited by
- 200
- References
- 4
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- green
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