Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury
Open accessAbstract
The well regulated activities of microglia and T cells specific to central nervous system (CNS) antigens can contribute to the protection of CNS neural cells and their renewal from adult neural stem/progenitor cells (aNPCs). Here we report that T cell-based vaccination of mice with a myelin-derived peptide, when combined with transplantation of aNPCs into the cerebrospinal fluid (CSF), synergistically promoted functional recovery after spinal cord injury. The synergistic effect was correlated with modulation of the nature and intensity of the local T cell and microglial response, expression of brain-derived neurotrophic factor and noggin protein, and appearance of newly formed neurons from endogenous precursor-cell pools. These results substantiate the contention that the local immune response plays a crucial role in recruitment of aNPCs to the lesion site, and suggest that similar immunological manipulations might also serve as a therapeutic means for controlled migration of stem/progenitor cells to other acutely injured CNS sites.
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The optimal time for injection of these cells was one week post-injury, suggesting early M1 polarization may play a beneficial role in CNS remodeling similar to skeletal muscle.
“It was also shown that the optimal time for injection of these cells was one week post-injury, suggesting that early M1 polarization may play a beneficial role in CNS remodeling following injury, similar to that observed in skeletal muscle [136].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [136]
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“It was also shown that the optimal time for injection of these cells was one week post-injury, suggesting that early M1 polarization may play a beneficial role in CNS remodeling following injury, similar to that observed in skeletal muscle [136].”
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Self-citationSingle-cell analysis reveals T cell infiltration in old neurogenic niches
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- Authors
- Ziv, Y., Avidan, H., Pluchino, S., Martino, G., & Schwartz, M.
- Affiliations
- Weizmann Institute of Science (IL)
- IRCCS Ospedale San Raffaele (IT)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-08-29
- Volume
- 103
- Issue
- 35
- Pages
- 13174-13179
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1559772
- OpenAlex
- W2051992221
- Cited by
- 285
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 8 · 2017: 15 · 2016: 15 · 2015: 20 · 2014: 18 · 2013: 24 · 2012: 23
- FWCI
- 16.55
- Type
- journal article
- Language
- en
- Update notices
- correction (2006-11-28)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- spinal cord injury, microglia, T cells, cell transplantation, cerebrospinal fluid, functional recovery, brain-derived neurotrophic factor, noggin, endogenous neurogenesis, immune response, stem cell migration
- MeSH terms
- Noggin Protein, Animals, Carrier Proteins, Cell Differentiation, Mice, Inbred C57BL, Myelin Proteins, Myelin Sheath, Neurons, Spinal Cord, Spinal Cord Injuries, Stem Cells, T-Lymphocytes, Vaccination, Wound Healing, Microglia, Myelin-Associated Glycoprotein, Brain-Derived Neurotrophic Factor, Stem Cell Transplantation, Green Fluorescent Proteins, Mice, Myelin-Oligodendrocyte Glycoprotein
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