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Cited by 265Neurogenesis and neuroplasticity mechanismsFetal and Pediatric Neurological DisordersElectromagnetic Fields and Biological Effects

Prenatal exposure to ultrasound waves impacts neuronal migration in mice

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Ang, Eugenius S. B. C., Gluncic, Vicko, Duque, Alvaro, Schafer, Mark E., Rakic, Pasko·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0605294103
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Abstract

Neurons of the cerebral neocortex in mammals, including humans, are generated during fetal life in the proliferative zones and then migrate to their final destinations by following an inside-to-outside sequence. The present study examined the effect of ultrasound waves (USW) on neuronal position within the embryonic cerebral cortex in mice. We used a single BrdU injection to label neurons generated at embryonic day 16 and destined for the superficial cortical layers. Our analysis of over 335 animals reveals that, when exposed to USW for a total of 30 min or longer during the period of their migration, a small but statistically significant number of neurons fail to acquire their proper position and remain scattered within inappropriate cortical layers and/or in the subjacent white matter. The magnitude of dispersion of labeled neurons was variable but systematically increased with duration of exposure to USW. These results call for a further investigation in larger and slower-developing brains of non-human primates and continued scrutiny of unnecessarily long prenatal ultrasound exposure.

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Crossref · 10.1073/pnas.0605294103

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  • Multiple fetuses per pregnancy, intrauterine growth restriction (IUGR), X-ray, UV, nuclear or cosmic radiation, (ultra)sound as well as high temperature, preterm birth or hypoxia whether or not by traumatic causes can pose serious threats to proper corticogenesis.

    “Multiple fetuses per pregnancy, intrauterine growth restriction (IUGR, due to placental failure other than by causes described above), X-ray, UV, nuclear or cosmic radiation, (ultra)sound as well as high temperature, preterm birth or hypoxia whether or not by traumatic causes can pose serious threats to proper corticogenesis as well [349–356].”

    From Development of prefrontal cortex (2022) · cites this paper as [354]

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Authors
Ang, E. S. B. C., Gluncic, V., Duque, A., Schafer, M. E., & Rakic, P.
Affiliations
  • Yale University (US)
  • *Department of Neurobiology and Kavli Institute for Neuroscience, Yale Medical School, Sterling Hall of Medicine, Room C-318, 333 Cedar Street, New Haven, CT 06510; and
  • Sonic Tech, Inc., 23 Brookline Court, Ambler, PA 19002
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2006-08-22
Volume
103
Issue
34
Pages
12903-12910
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0605294103
OpenAlex
W2049591511
Cited by
265
References
51
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 66 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 10
FWCI
4.80
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
Keywords
prenatal ultrasound exposure, neuronal migration, cerebral cortex, cortical lamination, BrdU labeling, white matter, embryonic brain development, mouse embryo
MeSH terms
Animals, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Female, Neurons, Pregnancy, Ultrasonography, Mice

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