The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
Open accessAbstract
The TRP family of ion channels transduce an extensive range of chemical and physical signals. TRPC6 is a receptor-activated nonselective cation channel expressed widely in vascular smooth muscle and other cell types. We report here that TRPC6 is also a sensor of mechanically and osmotically induced membrane stretch. Pressure-induced activation of TRPC6 was independent of phospholipase C. The stretch responses were blocked by the tarantula peptide, GsMTx-4, known to specifically inhibit mechanosensitive channels by modifying the external lipid-channel boundary. The GsMTx-4 peptide also blocked the activation of TRPC6 channels by either receptor-induced PLC activation or by direct application of diacylglycerol. The effects of the peptide on both stretch- and diacylglycerol-mediated TRPC6 activation indicate that the mechanical and chemical lipid sensing by the channel has a common molecular mechanism that may involve lateral-lipid tension. The mechanosensing properties of TRPC6 channels highly expressed in smooth muscle cells are likely to play a key role in regulating myogenic tone in vascular tissue.
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
AN INTRODUCTION TO TRP CHANNELS
Ramsey, I. S., Delling, M., & Clapham, D. E. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040204.100431 · Cited by 1,551
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,495
A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
Winn, M. P., Conlon, P. J., Lynn, K. L., Farrington, M. K., Creazzo, T., Hawkins, A. F., Daskalakis, N., Kwan, S. Y., Ebersviller, S., Burchette, J. L., et al. (2005) · Science · doi:10.1126/science.1106215 · Cited by 1,104
Signaling Mechanisms Underlying the Vascular Myogenic Response
Davis, M. J., & Hill, M. A. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.2.387 · Cited by 992
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
Reiser, J., Polu, K. R., Möller, C. C., Kenlan, P., Altintas, M. M., Wei, C., Faul, C., Herbert, S., Villegas, I., Avila-Casado, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1592 · Cited by 863
TRPC1 forms the stretch-activated cation channel in vertebrate cells
Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B., & Hamill, O. P. (2005) · Nature Cell Biology · doi:10.1038/ncb1218 · Cited by 663
Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries
Welsh, D. G., Morielli, A. D., Nelson, M. T., & Brayden, J. E. (2002) · Circulation Research · doi:10.1161/hh0302.105662 · Cited by 512
Yu, Y., Fantozzi, I., Remillard, C. V., Landsberg, J. W., Kunichika, N., Platoshyn, O., Tigno, D. D., Thistlethwaite, P. A., Rubin, L. J., & Yuan, J. X.-J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405908101 · Cited by 430
Cited by
Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Molecular basis of physiological heart growth: fundamental concepts and new players
Maillet, M., van Berlo, J. H., & Molkentin, J. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3495 · Cited by 536
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Metadata
- Authors
- Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-10-31
- Volume
- 103
- Issue
- 44
- Pages
- 16586-16591
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039931031
- Cited by
- 517
- References
- 30
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L. (2006). A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0606894103
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