The DOI matches its Crossref record.
Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries
Open accessAbstract
Elevation of intravascular pressure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and this response is a key element in blood flow regulation. However, the nature of pressure-induced depolarization has remained elusive. In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure. Antisense oligodeoxynucleotides to TRPC6 decreased TRPC6 protein expression and greatly attenuated arterial smooth muscle depolarization and constriction caused by elevated pressure in intact cerebral arteries. Suppressing the expression of this channel protein also reduced the current density of a major cation current in resistance artery smooth muscle cells. We propose that TRPC6 channels play an essential role in regulation of myogenic tone.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2016 · Cited by 522
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Ion channel networks in the control of cerebral blood flow
Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137
Self-citationLocal Regulation of Microvascular Perfusion
Davis, M. J., Hill, M. A., & Kuo, L. (2008) · Microcirculation · doi:10.1016/b978-0-12-374530-9.00006-1 · Cited by 78
Metadata
- Authors
- Welsh, D. G., Morielli, A. D., Nelson, M. T., & Brayden, J. E.
- Venue
- Circulation Research
- Published
- 2002-02-22
- Volume
- 90
- Issue
- 3
- Pages
- 248-250
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2036082842
- Cited by
- 512
- References
- 0
- FWCI
- 10.41
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries. https://app.cochat.ai/papers/10.1161/hh0302.105662
- The paper
- Welsh, D. G., Morielli, A. D., Nelson, M. T., & Brayden, J. E. (2002). Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries. Circulation Research. https://doi.org/10.1161/hh0302.105662
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
