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Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish

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Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

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Structural Determinants of Unique Properties of Human IgG4-Fc

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HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

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TRIM21/Ro52 - Roles in Innate Immunity and Autoimmune Disease

Jones, E. L., Laidlaw, S. M., & Dustin, L. B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738473 · Cited by 112 · see citing works

Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1

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Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders

Lu, P., Cheng, Y., Xue, L., Ren, X., Xu, X., Chen, C., Cao, L., Li, J., Wu, Q., Sun, S., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.015 · Cited by 114 · see citing works

TRIM21 – A potential novel therapeutic target in cancer

Alomari, M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105443 · Cited by 110 · see citing works

TRIM 21: a cytosolic Fc receptor with broad antibody isotype specificity

Foss, S., Watkinson, R., Sandlie, I., James, L. C., & Andersen, J. T. (2015) · Immunological Reviews · doi:10.1111/imr.12363 · Cited by 108 · see citing works

IgG4 Characteristics and Functions in Cancer Immunity

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Target-induced clustering activates Trim-Away of pathogens and proteins

Zeng, J., Santos, A. F., Mukadam, A. S., Osswald, M., Jacques, D. A., Dickson, C. F., McLaughlin, S. H., Johnson, C. M., Kiss, L., Lupták, J., et al. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00560-2 · Cited by 106 · see citing works

A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways

Dong, W., Wei, X., Zhang, F., Hao, J., Huang, F., Zhang, C., & Liang, W. P. (2014) · Scientific Reports · doi:10.1038/srep07237 · Cited by 103 · see citing works

AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization

Hauler, F., Mallery, D. L., McEwan, W. A., Bidgood, S. R., & James, L. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210659109 · Cited by 101 · see citing works

TRIM21 and the Function of Antibodies inside Cells

Rhodes, D. A., & Isenberg, D. A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.07.005 · Cited by 102 · see citing works

Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy

Nimmerjahn, F., Vidarsson, G., & Cragg, M. S. (2023) · Nature Immunology · doi:10.1038/s41590-023-01544-8 · Cited by 102 · see citing works

Intracellular antibody receptor TRIM21 prevents fatal viral infection

Vaysburd, M., Watkinson, R. E., Cooper, H., Reed, M., O’Connell, K., Smith, J. L., Cruickshanks, J., & James, L. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301918110 · Cited by 98 · see citing works

BTN3A2 Expression in Epithelial Ovarian Cancer Is Associated with Higher Tumor Infiltrating T Cells and a Better Prognosis

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TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

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Antibodies and Their Receptors: Different Potential Roles in Mucosal Defense

Horton, R. E., & Vidarsson, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00200 · Cited by 96 · see citing works

Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis

Thom, C. S., Traxler, E. A., Khandros, E., Nickas, J. M., Zhou, O. Y., Lazarus, J. E., Silva, A. P. G., Prabhu, D., Yao, Y., Aribeana, C. N., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.021 · Cited by 96 · see citing works

Advances in targeted degradation of endogenous proteins

Röth, S., Fulcher, L. J., & Sapkota, G. P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03112-6 · Cited by 92 · see citing works

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

Dickson, C. F., Fletcher, A. J., Vaysburd, M., Yang, J., Mallery, D. L., Zeng, J., Johnson, C. M., McLaughlin, S. H., Skehel, M. J., Maslen, S., et al. (2018) · eLife · doi:10.7554/elife.32660 · Cited by 93 · see citing works

HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome

Song, Y., Wu, X., Xu, Y., Zhu, J., Li, J., Zou, Z., Chen, L., Zhang, B., Hua, C., Han, R., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.50074 · Cited by 92 · see citing works

Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers

Weinert, C., Morger, D., Djekic, A., Grütter, M. G., & Mittl, P. R. E. (2015) · Scientific Reports · doi:10.1038/srep10819 · Cited by 91 · see citing works

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Kato, K., Ahmad, S., Zhu, Z., Young, J. M., Mu, X. N., Park, S., Malik, H. S., & Hur, S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.11.047 · Cited by 88 · see citing works

Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface

Espinosa, A., Hennig, J., Ambrosi, A., Anandapadmanaban, M., Abelius, M. S., Sheng, Y., Nyberg, F., Arrowsmith, C. H., Sunnerhagen, M., & Wahren‐Herlenius, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241786 · Cited by 90 · see citing works

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

McEwan, W. A., Hauler, F., Williams, C. R., Bidgood, S. R., Mallery, D. L., Crowther, R. A., & James, L. C. (2012) · Journal of Virology · doi:10.1128/jvi.00728-12 · Cited by 90 · see citing works

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

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Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

Biris, N., Yang, Y., Taylor, A. B., Tomashevski, A., Guo, M., Hart, P. J., Diaz‐Griffero, F., & Ivanov, D. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203536109 · Cited by 89 · see citing works

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design

Caaveiro, J. M. M., Kiyoshi, M., & Tsumoto, K. (2015) · Immunological Reviews · doi:10.1111/imr.12365 · Cited by 87 · see citing works

Conserved structural and functional aspects of the tripartite motif gene family point towards therapeutic applications in multiple diseases

Gushchina, L. V., Kwiatkowski, T. A., Bhattacharya, S., & Weisleder, N. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.020 · Cited by 85 · see citing works

Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells

Gu, S., Nawrocka, W. I., & Adams, E. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00688 · Cited by 85 · see citing works

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models

Mukadam, A. S., Miller, L. V. C., Smith, A. E., Vaysburd, M., Sakya, S. A., Sanford, S., Keeling, S., Tuck, B. J., Katsinelos, T., Green, C., et al. (2023) · Science · doi:10.1126/science.abn1366 · Cited by 83 · see citing works

Monoclonal antibodies: technologies for early discovery and engineering

Kennedy, P. J., Oliveíra, C., Granja, P. L., & Sarmento, B. F. C. C. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1357002 · Cited by 85 · see citing works

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces

Zhao, G., Ke, D., Vu, T., Ahn, J., Shah, V. B., Yang, R., Aiken, C., Charlton, L. M., Gronenborn, A. M., & Zhang, P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002009 · Cited by 84 · see citing works

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

Rispens, T., Davies, A. M., Heer, P. O., Absalah, S., Bende, O., Sutton, B. J., Vidarsson, G., & Aalberse, R. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.541813 · Cited by 84 · see citing works

Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity

Caddy, S., Vaysburd, M., Papa, G., Wing, M. G., O’Connell, K., Stoycheva, D., Foss, S., Andersen, J. T., Oxenius, A., & James, L. C. (2020) · The EMBO Journal · doi:10.15252/embj.2020106228 · Cited by 79 · see citing works

The PRY/SPRY/B30.2 Domain of Butyrophilin 1A1 (BTN1A1) Binds to Xanthine Oxidoreductase

Jeong, J., Rao, A. U., Xu, J., Ogg, S. L., Hathout, Y., Fenselau, C., & Mather, I. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020446 · Cited by 80 · see citing works

A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

Zhang, J., Xiong, H., Cao, J., Wang, S., Guo, X., Lin, B., Zhang, Y., Zhao, J.-H., Wang, Y.-B., Zhang, T., et al. (2017) · Theranostics · doi:10.7150/thno.20047 · Cited by 79 · see citing works

Intracellular neutralisation of rotavirus by VP6-specific IgG

Caddy, S., Vaysburd, M., Wing, M. G., Foss, S., Andersen, J. T., O‘Connell, K., Mayes, K., Higginson, K., Iturriza‐Gómara, M., Desselberger, U., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008732 · Cited by 79 · see citing works

TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation

Sun, Y., Ren, D., Yang, C., Yang, W., Zhao, J., Zhou, Y., Jin, X., & Wu, H. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166213 · Cited by 79 · see citing works

Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells

Bidgood, S. R., Tam, J. C. H., McEwan, W. A., Mallery, D. L., & James, L. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410980111 · Cited by 78 · see citing works

Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

Wang, H., & Morita, C. T. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500314 · Cited by 75 · see citing works

An expanded clade of rodent Trim5 genes

Tareen, S. U., Sawyer, S. L., Malik, H. S., & Emerman, M. (2009) · Virology · doi:10.1016/j.virol.2008.12.018 · Cited by 73 · see citing works

An Active TRIM5 Protein in Rabbits Indicates a Common Antiviral Ancestor for Mammalian TRIM5 Proteins

Schaller, T., Hué, S., & Towers, G. J. (2007) · Journal of Virology · doi:10.1128/jvi.01468-07 · Cited by 73 · see citing works

A survey of the year 2007 literature on applications of isothermal titration calorimetry

Bjelić, S., & Jelesarov, I. (2008) · Journal of Molecular Recognition · doi:10.1002/jmr.909 · Cited by 71 · see citing works

Anti‐retroviral activity of TRIM5α

Nakayama, E. E., & Shioda, T. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.637 · Cited by 71 · see citing works

Defining the Turkey MHC: Sequence and Genes of the B Locus

Chaves, L. D., Krueth, S. B., & Reed, K. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901310 · Cited by 70 · see citing works

Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5α Protein

Kar, A. K., Diaz‐Griffero, F., Li, Y., Li, X., & Sodroski, J. (2008) · Journal of Virology · doi:10.1128/jvi.01559-08 · Cited by 70 · see citing works

TRIpartite Motif 21 (TRIM21) Differentially Regulates the Stability of Interferon Regulatory Factor 5 (IRF5) Isoforms

Lazzari, E., Korczeniewska, J., Gabhann, J. N., Smith, S., Barnes, B. J., & Jefferies, C. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103609 · Cited by 70 · see citing works

Exploring the diversity of SPRY/B30.2-mediated interactions

Perfetto, L., Gherardini, P. F., Davey, N. E., Diella, F., Helmer‐Citterich, M., & Cesareni, G. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.10.001 · Cited by 70 · see citing works

Protective mechanisms of nonneutralizing antiviral antibodies

Chandler, T. L., Yang, A., Otero, C. E., Permar, S. R., & Caddy, S. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011670 · Cited by 69 · see citing works

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway

Sun, Y., Ji, B., Feng, Y., Zhang, Y., Ji, D., Zhu, C., Wang, S., Zhang, C., Zhang, D., & Sun, Y. (2017) · Oncology Reports · doi:10.3892/or.2017.5654 · Cited by 69 · see citing works

Cytosolic delivery of inhibitory antibodies with cationic lipids

Wang, H. H., & Tsourkas, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913973116 · Cited by 68 · see citing works

The spectrum of monogenic autoinflammatory syndromes: Understanding disease mechanisms and use of targeted therapies

Glaser, R. L., & Goldbach‐Mansky, R. T. (2008) · Current Allergy and Asthma Reports · doi:10.1007/s11882-008-0047-1 · Cited by 68 · see citing works

Mode of Transmission Affects the Sensitivity of Human Immunodeficiency Virus Type 1 to Restriction by Rhesus TRIM5α

Richardson, M. W., Carroll, R. G., Stremlau, M. H., Korokhov, N., Humeau, L. M. P. F., Silvestri, G., Sodroski, J., & Riley, J. L. (2008) · Journal of Virology · doi:10.1128/jvi.01046-08 · Cited by 68 · see citing works

TRIM21‐mediated proteasomal degradation of SAMHD1 regulates its antiviral activity

Li, Z., Huan, C., Wang, H., Liu, Y., Liu, X., Su, X., Yu, J., Zhao, Z., Yu, X., Zheng, B., et al. (2019) · EMBO Reports · doi:10.15252/embr.201847528 · Cited by 66 · see citing works

Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Filippakopoulos, P., Low, A., Sharpe, T., Uppenberg, J., Yao, S., Kuang, Z., Savitsky, P. A., Lewis, R. S., Nicholson, S. E., Norton, R. S., et al. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.06.017 · Cited by 67 · see citing works

Antibodies and associates: Partners in targeted drug delivery

Kennedy, P. J., Oliveíra, C., Granja, P. L., & Sarmento, B. F. C. C. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.004 · Cited by 68 · see citing works

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

Keeble, A. H., Khan, Z., Forster, A., & James, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800159105 · Cited by 202 · see citing works

TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain

Rhodes, D. A., & Trowsdale, J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.013 · Cited by 95 · see citing works

TRIM protein domain topology and implications for antiviral immunity

Jacques, D. A., Jeffries, C. M., Caines, M. E. C., Lammers, M., Mallery, D. L., Price, A. J., McLaughlin, S. H., Johnson, C. M., Svergun, D. I., & James, L. C. (2014) · Acta Crystallographica Section A Foundations and Advances · doi:10.1107/s2053273314097563

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction

Yang, Y., Brandariz-Núñez, A., Fricke, T., Ivanov, D. N., Sarnak, Z., & Diaz‐Griffero, F. (2013) · Virology · doi:10.1016/j.virol.2013.10.012 · Cited by 32 · see citing works

Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

Biris, N., Yang, Y., Taylor, A. B., Tomashevski, A., Guo, M., Hart, P. J., Diaz‐Griffero, F., & Ivanov, D. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203536109 · Cited by 89 · see citing works