The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence
Open accessAbstract
Individualized, chemically pristine single-walled carbon nanotubes have been intravenously administered to rabbits and monitored through their characteristic near-infrared fluorescence. Spectra indicated that blood proteins displaced the nanotube coating of synthetic surfactant molecules within seconds. The nanotube concentration in the blood serum decreased exponentially with a half-life of 1.0 ± 0.1 h. No adverse effects from low-level nanotube exposure could be detected from behavior or pathological examination. At 24 h after i.v. administration, significant concentrations of nanotubes were found only in the liver. These results demonstrate that debundled single-walled carbon nanotubes are high-contrast near-infrared fluorophores that can be sensitively and selectively tracked in mammalian tissues using optical methods. In addition, the absence of acute toxicity and promising circulation persistence suggest the potential of carbon nanotubes in future pharmaceutical applications.
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Cites
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00009-3 · Cited by 1,474
Oops they did it again! Carbon nanotubes hoax scientists in viability assays
Wörle-Knirsch, J. M., Pulskamp, K., & Krug, H. F. (2006) · Nano Letters · doi:10.1021/nl060177c · Cited by 994
Optical Detection of DNA Conformational Polymorphism on Single-Walled Carbon Nanotubes
Heller, D. A., Jeng, E. S., Yeung, T.-K., Martinez, B. M., Moll, A. E., Gastala, J. B., & Strano, M. S. (2006) · Science · doi:10.1126/science.1120792 · Cited by 505
Izzo, F., Marra, P., Beneduce, G., Castello, G., Vallone, P., De Rosa, V., Cremona, F., Ensor, C. M., Holtsberg, F. W., Bomalaski, J. S., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.11.120 · Cited by 250
Self-citation
Cited by
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
An overview of nanoparticles commonly used in fluorescent bioimaging
Wolfbeis, O. S. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00392f · Cited by 1,631
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Liu, Z., Davis, C., Cai, W., He, L., Chen, X., & Dai, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707654105 · Cited by 1,116
Metadata
- Authors
- Cherukuri, P., Gannon, C. J., Leeuw, T. K., Schmidt, H. K., Smalley, R. E., Curley, S. A., & Weisman, R. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-12-12
- Volume
- 103
- Issue
- 50
- Pages
- 18882-18886
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097162294
- Cited by
- 491
- References
- 4
- FWCI
- 30.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cherukuri, P., Gannon, C. J., Leeuw, T. K., Schmidt, H. K., Smalley, R. E., Curley, S. A., & Weisman, R. B. (2006). Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0609265103
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