The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Caenorhabditis elegans SID-2 is required for environmental RNA interference
Open accessAbstract
In plants and in the nematode Caenorhabditis elegans , an RNAi signal can trigger gene silencing in cells distant from the site where silencing is initiated. In plants, this signal is known to be a form of dsRNA, and the signal is most likely a form of dsRNA in C. elegans as well. Furthermore, in C. elegans , dsRNA present in the environment or expressed in ingested bacteria is sufficient to trigger RNAi (environmental RNAi). Ingestion and soaking delivery of dsRNA has also been described for other invertebrates. Here we report the identification and characterization of SID-2, an intestinal luminal transmembrane protein required for environmental RNAi in C. elegans . SID-2, when expressed in the environmental RNAi defective species Caenorhabditis briggsae , confers environmental RNAi.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Specific interference by ingested dsRNA
Timmons, L., & Fire, A. (1998) · Nature · doi:10.1038/27579 · Cited by 1,899
Marsh, M., & Helenius, A. (2006) · Cell · doi:10.1016/j.cell.2006.02.007 · Cited by 1,186
Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R., & Paludan, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.5059-5064.2006 · Cited by 954
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000045 · Cited by 940
Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1
Winston, W. M., Molodowitch, C., & Hunter, C. P. (2002) · Science · doi:10.1126/science.1068836 · Cited by 846
Self-citationLarge-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
Maeda, I., Kohara, Y., Yamamoto, M., & Sugimoto, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00052-5 · Cited by 698
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map
Wicks, S. R., Yeh, R. T., Gish, W. R., Waterston, R. H., & Plasterk, R. H. A. (2001) · Nature Genetics · doi:10.1038/88878 · Cited by 648
RNAi in C. elegans : Soaking in the Genome Sequence
Tabara, H., Grishok, A., & Mello, C. C. (1998) · Science · doi:10.1126/science.282.5388.430 · Cited by 645
Transport of dsRNA into Cells by the Transmembrane Protein SID-1
Feinberg, E. H., & Hunter, C. P. (2003) · Science · doi:10.1126/science.1087117 · Cited by 585
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Cited by
Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection
Wang, M., Weiberg, A., Lin, F.-M., Thomma, B. P. H. J., Huang, H.-D., & Jin, H. (2016) · Nature Plants · doi:10.1038/nplants.2016.151 · Cited by 801
Mechanisms, Applications, and Challenges of Insect RNA Interference
Zhu, K. Y., & Palli, S. R. (2020) · Annual Review of Entomology · doi:10.1146/annurev-ento-011019-025224 · Cited by 709
RNAi-mediated crop protection against insects
Price, D. R. G., & Gatehouse, J. A. (2008) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.04.004 · Cited by 585
Bolognesi, R., Ramaseshadri, P., Anderson, J., Bachman, P., Clinton, W., Flannagan, R., Ilagan, O., Lawrence, C., Levine, S., Moar, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047534 · Cited by 473
Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges
Christiaens, O., Whyard, S., Vélez, A. M., & Smagghe, G. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00451 · Cited by 339
Metadata
- Authors
- Winston, W. M., Sutherlin, M., Wright, A. J., Feinberg, E. H., & Hunter, C. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-06-19
- Volume
- 104
- Issue
- 25
- Pages
- 10565-10570
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2151722180
- Cited by
- 309
- References
- 29
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Winston, W. M., Sutherlin, M., Wright, A. J., Feinberg, E. H., & Hunter, C. P. (2007). Caenorhabditis elegans SID-2 is required for environmental RNA interference. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0611282104
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