The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach
Open accessAbstract
We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral NS1 proteins are highly attenuated in the mouse host, yet provide protection from challenge with wild-type viruses.
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Cites
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Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
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Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems
García-Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P., & Muster, T. (1998) · Virology · doi:10.1006/viro.1998.9508 · Cited by 1,000
Self-citationA universal influenza A vaccine based on the extracellular domain of the M2 protein
Neirynck, S., Deroo, T., Saelens, X., Vanlandschoot, P., Jou, W. M., & Fiers, W. (1999) · Nature Medicine · doi:10.1038/13484 · Cited by 752
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The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins
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Self-citationAmplification, expression, and packaging of a foreign gene by influenza virus
Luytjes, W., Krystal, M., Enami, M., Parvin, J. D., & Palese, P. (1989) · Cell · doi:10.1016/0092-8674(89)90766-6 · Cited by 441
Self-citationDidcock, L., Young, D. F., Goodbourn, S., & Randall, R. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.9928-9933.1999 · Cited by 422
Cited by
SARS-CoV-2 vaccines in development
Krammer, F. (2020) · Nature · doi:10.1038/s41586-020-2798-3 · Cited by 2,098
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy, D. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00027-7 · Cited by 428
Influenza A Virus PB1-F2 Protein Contributes to Viral Pathogenesis in Mice
Zamarin, D., Ortigoza, M. B., & Palese, P. (2006) · Journal of Virology · doi:10.1128/jvi.00415-06 · Cited by 304
Self-citationNew Vaccine Design and Delivery Technologies
Kanekiyo, M., Ellis, D., & King, N. P. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy745 · Cited by 69
Metadata
- Authors
- Talon, J., Salvatore, M., O'Neill, R. E., Nakaya, Y., Zheng, H., Muster, T., García-Sastre, A., & Palese, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-21
- Volume
- 97
- Issue
- 8
- Pages
- 4309-4314
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2051690374
- Cited by
- 320
- References
- 25
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Talon, J., Salvatore, M., O'Neill, R. E., Nakaya, Y., Zheng, H., Muster, T., García-Sastre, A., & Palese, P. (2000). Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.070525997
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
