Cited by 212Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesEating Disorders and Behaviors

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

Open access
Baicy, Kate, London, Edythe D., Monterosso, John, Wong, Ma-Li, Delibasi, Tuncay, Sharma, Anil, Licinio, Julio·2007·Proceedings of the National Academy of Sciences

Abstract

A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.

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Crossref · 10.1073/pnas.0706481104

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27 of 27 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Baicy, K., London, E. D., Monterosso, J., Wong, M.-L., Delibasi, T., Sharma, A., & Licinio, J.
Affiliations
  • University of California, Los Angeles (US)
  • Department of Psychiatry and Biobehavioral Sciences and Semel Institute, and
  • University of Miami (US)
  • Center for Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136; and
Venue
Proceedings of the National Academy of Sciences
Published
2007-11-13
Volume
104
Issue
46
Pages
18276-18279
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2094808974
Cited by
212
References
27
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 20 · 2012: 25
FWCI
5.85
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (DA021961, P20DA022539, DA 022539, R01DA020726, DA 020726, F30DA021961)
  • National Institute of General Medical Sciences (U01GM061394, GM-08042, GM061394, T32GM008042)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 058851, R01DK063240, DK-063240, R01DK058851)
  • National Center for Research Resources (RR 016996, RR00865, K24RR017365, M01RR000865, K24RR016996, RR017365)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
leptin replacement, leptin deficiency, food cues, hunger, satiety, feeding behavior, insula, prefrontal cortex, obesity, brain activation, dietary habits
MeSH terms
Brain, Feeding Behavior, Humans, Magnetic Resonance Imaging, Leptin

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