The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.
Open accessAbstract
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.
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In the citing paper
“Normal individuals typically show this activity only in the starved state and do not show this response after eating.”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [53]
In the citing paper
“Consistent with this, functional magnetic resonance imaging of leptin-deficient subjects has revealed a marked increase in activity in the nucleus accumbens in response to images of food even after eating (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [53]
In the citing paper
“In addition, leptin-deficient patients show markedly different food preferences and perception of food than do normal individuals (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [53]
In the citing paper
“The activity that is seen in the accumbens in leptin-deficient patients after eating was normalized by the use of leptin therapy (52)(53)(54).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [53]
Citations
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406
The role of the medial frontal cortex in cognitive control
Ridderinkhof, K. R., Ullsperger, M., Crone, E. A., & Nieuwenhuis, S. (2004) · Science · doi:10.1126/science.1100301 · Cited by 2,974
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442
Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936
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Possibile azione “cognitiva” e comportamentale della leptina
Palladino, L., & Ceccarini, G. (2023) · L Endocrinologo · doi:10.1007/s40619-023-01340-4
Moreira, A. C. D. A. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-09052024-115645
Leptin-related disorders of the nervous system
Saez-Calveras, N., Ishii, M., Elmquist, J. K., & Williams, K. W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00027-3
Bachmann, T., Mueller, K., Kusnezow, S. N. A., Schroeter, M. L., Piaggi, P., & Weise, C. M. (2025) · GigaScience · doi:10.1093/gigascience/giaf010
Wang, G., Volkow, N. D., Fowler, J. S., & Thanos, P. K. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782091.035
Rajendiran, M., Palani, S., & Subramaniyan, V. (2026) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2026.107093
The acute effects of dietary protein at breakfast on reward driven neural activity prior to lunch
Harris, C. T. (2010) · KU ScholarWorks (The University of Kansas)
Neuroimaging-Verfahren in der Adipositasforschung
Kabisch, S., Schlögl, H., Villringer, A., & Stümvoll, M. (2011) · Max Planck Digital Library
Ahima, R. S., & Varela, G. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00332-6
Metadata
- Authors
- Baicy, K., London, E. D., Monterosso, J., Wong, M.-L., Delibasi, T., Sharma, A., & Licinio, J.
- Affiliations
- University of California, Los Angeles (US)
- Department of Psychiatry and Biobehavioral Sciences and Semel Institute, and
- University of Miami (US)
- Center for Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-11-13
- Volume
- 104
- Issue
- 46
- Pages
- 18276-18279
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2084333
- OpenAlex
- W2094808974
- Cited by
- 212
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 20 · 2012: 25
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA021961, P20DA022539, DA 022539, R01DA020726, DA 020726, F30DA021961)
- National Institute of General Medical Sciences (U01GM061394, GM-08042, GM061394, T32GM008042)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 058851, R01DK063240, DK-063240, R01DK058851)
- National Center for Research Resources (RR 016996, RR00865, K24RR017365, M01RR000865, K24RR016996, RR017365)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- leptin replacement, leptin deficiency, food cues, hunger, satiety, feeding behavior, insula, prefrontal cortex, obesity, brain activation, dietary habits
- MeSH terms
- Brain, Feeding Behavior, Humans, Magnetic Resonance Imaging, Leptin
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