A model for the role of integrins in flow induced mechanotransduction in osteocytes

Untitled work

Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works

Cellular mechanotransduction: putting all the pieces together again

Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627 · see citing works

Regulation of bone formation by applied dynamic loads.

Rubin, C. T., & Lanyon, L. E. (1984) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198466030-00012 · Cited by 1,564 · see citing works

Principles and Techniques of Electron Microscopy: Biological Applications

Maugel, T. K., & Hayat, M. A. (1979) · Transactions of the American Microscopical Society · doi:10.2307/3226038 · Cited by 1,327 · see citing works

Regulation of bone mass by mechanical strain magnitude

Rubin, C. T., & Lanyon, L. E. (1985) · Calcified Tissue International · doi:10.1007/bf02553711 · Cited by 1,297 · see citing works

A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses

Weinbaum, S., Cowin, S. C., & Zeng, Y. (1994) · Journal of Biomechanics · doi:10.1016/0021-9290(94)90010-8 · Cited by 1,266 · see citing works

Mechanotransduction in bone—role of the lacunocanalicular network

Burger, E. H., & Klein‐Nulend, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9001.s101 · Cited by 897 · see citing works

Pannexin membrane channels are mechanosensitive conduits for ATP

Bao, L., Locovei, S., & Dahl, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.009 · Cited by 804 · see citing works

Integrins in Mechanotransduction

Katsumi, A., Orr, A. W., Tzima, E., & Schwartz, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300038200 · Cited by 724 · see citing works

Low mechanical signals strengthen long bones

Rubin, C. T., Turner, A. S., Bain, S. D., Mallinckrodt, C. H., & McLeod, K. J. (2001) · Nature · doi:10.1038/35088122 · Cited by 724 · see citing works

Mechanotransduction and flow across the endothelial glycocalyx

Weinbaum, S., Zhang, X., Han, Y., Vink, H., & Cowin, S. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332808100 · Cited by 579 · see citing works

Mechanotransduction and strain amplification in osteocyte cell processes

Han, Y., Cowin, S. C., Schaffler, M. B., & Weinbaum, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407429101 · Cited by 495 · see citing works

Candidates for the Mechanosensory System in Bone

Cowin, S. C., Moss‐Salentijn, L., & Moss, M. L. (1991) · Journal of Biomechanical Engineering · doi:10.1115/1.2891234 · Cited by 470 · see citing works

A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix

You, L., Cowin, S. C., Schaffler, M. B., & Weinbaum, S. (2001) · Journal of Biomechanics · doi:10.1016/s0021-9290(01)00107-5 · Cited by 419 · see citing works

Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains

Fritton, S. P., McLeod, K. J., & Rubin, C. T. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(99)00210-9 · Cited by 405 · see citing works

Force Measurements of the α5β1 Integrin–Fibronectin Interaction

Li, F., Redick, S. D., Erickson, H., & Moy, V. T. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74940-6 · Cited by 378 · see citing works

Substrate Deformation Levels Associated With Routine Physical Activity Are Less Stimulatory to Bone Cells Relative to Loading-Induced Oscillatory Fluid Flow

You, J., Yellowley, C. E., Donahue, H. J., Zhang, Y., Chen, Q., & Jacobs, C. R. (2000) · Journal of Biomechanical Engineering · doi:10.1115/1.1287161 · Cited by 357 · see citing works

Ultrastructure of the osteocyte process and its pericellular matrix

You, L., Weinbaum, S., Cowin, S. C., & Schaffler, M. B. (2004) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.20050 · Cited by 328 · see citing works

Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO‐Y4 osteocytes

Genetos, D. C., Kephart, C. J., Zhang, Y., Yellowley, C. E., & Donahue, H. J. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21021 · Cited by 328 · see citing works

Principles and Techniques of Electron Microscopy

Hayat, M. A. (1989) · doi:10.1007/978-1-349-09857-6 · Cited by 325 · see citing works

Single Integrin Molecule Adhesion Forces in Intact Cells Measured by Atomic Force Microscopy

Lehenkari, P. P., & Horton, M. A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0827 · Cited by 287 · see citing works

The P2X7 Nucleotide Receptor Mediates Skeletal Mechanotransduction

Li, J., Liu, D., Ke, H. Z., Duncan, R. L., & Turner, C. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506415200 · Cited by 269 · see citing works

Bone matrix proteins: their function, regulation, and relationship to osteoporosis

Young, M. F. (2003) · Osteoporosis International · doi:10.1007/s00198-002-1342-7 · Cited by 243 · see citing works

Induction of NO and prostaglandin E2in osteoblasts by wall-shear stress but not mechanical strain

Smalt, R., Mitchell, F. T., Howard, R. L., & Chambers, T. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e751 · Cited by 220 · see citing works

INTEGRINS AND STRETCH ACTIVATED ION CHANNELS; PUTATIVE COMPONENTS OF FUNCTIONAL CELL SURFACE MECHANORECEPTORS IN ARTICULAR CHONDROCYTES

Mobasheri, A., Carter, S. D., Martı́n-Vasallo, P., & Shakibaei, M. (2002) · Cell Biology International · doi:10.1006/cbir.2001.0826 · Cited by 215 · see citing works

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain

Rawlinson, S. C. F., Pitsillides, A. A., & Lanyon, L. E. (1996) · Bone · doi:10.1016/s8756-3282(96)00260-8 · Cited by 185 · see citing works

An Atomic Model of Actin Filaments Cross-Linked by Fimbrin and Its Implications for Bundle Assembly and Function

Volkmann, N., DeRosier, D. J., Matsudaira, P. T., & Hanein, D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.947 · Cited by 169 · see citing works

Regulation of the L-type Calcium Channel by α5β1 Integrin Requires Signaling between Focal Adhesion Proteins

Wu, X. Y., Davis, G. E., Meininger, G. A., Wilson, E., & Davis, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102436200 · Cited by 168 · see citing works

Reconstitution of stretch-activated cation channels by expression of the α-subunit of the epithelial sodium channel cloned from osteoblasts

Kizer, N. L., Guo, X.-L., & Hruska, K. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.1013 · Cited by 158 · see citing works

Complex functional interaction between integrin receptors and ion channels

Arcangeli, A., & Becchetti, A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.10.003 · Cited by 144 · see citing works

A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon

Zeng, Y., Cowin, S. C., & Weinbaum, S. (1994) · Annals of Biomedical Engineering · doi:10.1007/bf02368235 · Cited by 129 · see citing works

Protein–protein unbinding induced by force: single-molecule studies

Weisel, J. W. (2003) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(03)00039-3 · Cited by 124 · see citing works

Regulation of Free Ca2+Concentration in Hair-Cell Stereocilia

Lumpkin, E. A., & Hudspeth, A. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06300.1998 · Cited by 124 · see citing works

L-Type Calcium Channels Mediate Mechanically Induced Bone Formation In Vivo

Li, J., Duncan, R. L., Burr, D. B., & Turner, C. H. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.10.1795 · Cited by 114 · see citing works

Parathyroid Hormone Enhances Fluid Shear-Induced [Ca2+]i Signaling in Osteoblastic Cells Through Activation of Mechanosensitive and Voltage-Sensitive Ca2+ Channels

Ryder, K. D., & Duncan, R. L. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.2.240 · Cited by 114 · see citing works

Principles and techniques of histochemistry

Troyer, H. (1980) · Andalas University Repository (Andalas University) · Cited by 107 · see citing works

Fluid flow induced PGE 2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not

Reilly, G. C., Haut, T. R., Yellowley, C. E., Donahue, H. J., & Jacobs, C. R. (2003) · Biorheology · doi:10.1177/0006355x2003040006005 · Cited by 106 · see citing works

Parathyroid Hormone-activated Volume-sensitive Calcium Influx Pathways in Mechanically Loaded Osteocytes

Miyauchi, A., Notoya, K., Mikuni‐Takagaki, Y., Takagi, Y., Goto, M., 三木, 善., Takano‐Yamamoto, T., Jinnai, K., Takahashi, K., Kumegawa, M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3335 · Cited by 104 · see citing works

Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells

Duncan, R. L., & Hruska, K. A. (1994) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1994.267.6.f909 · Cited by 100 · see citing works

Female sex hormones inhibit volume regulation in rat brain astrocyte culture

Fraser, C. L., & Swanson, R. A. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.4.c909 · Cited by 98 · see citing works

Integrin Receptor Activation Triggers Converging Regulation of Cav1.2 Calcium Channels by c-Src and Protein Kinase A Pathways

Gui, P., Wu, X. Y., Ling, S., Stotz, S. C., Winkfein, R. J., Wilson, E., Davis, G. E., Braun, A. P., Zamponi, G. W., & Davis, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600433200 · Cited by 97 · see citing works

Localization of CD44, the hyaluronate receptor, on the plasma membrane of osteocytes and osteoclasts in rat tibiae

Nakamura, H., Kenmotsu, S., Sakai, H., & Ozawa, H. (1995) · Cell and Tissue Research · doi:10.1007/bf00307793 · Cited by 90 · see citing works

Pattern of focal γ-bursts in chess players

Amidzic, O., Riehle, H. J., Fehr, T., Wienbruch, C., & Elbert, T. R. (2001) · Nature · doi:10.1038/35088119 · Cited by 86 · see citing works

Estimating the Sensitivity of Mechanosensitive Ion Channels to Membrane Strain and Tension

Charras, G., Williams, B. A., Sims, S. M., & Horton, M. A. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.040436 · Cited by 76 · see citing works

Beta1-integrins co-localize with Na, K-ATPase, epithelial sodium channels (ENaC) and voltage activated calcium channels (VACC) in mechanoreceptor complexes of mouse limb-bud chondrocytes.

Shakibaei, M., & Mobasheri, A. (2003) · PubMed · doi:10.14670/hh-18.343 · Cited by 76 · see citing works

αVβ3 Integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes

Miyauchi, A., Gotoh, M., Kamioka, H., Notoya, K., Sekiya, H., Takagi, Y., Yoshimoto, Y., Ishikawa, H., Chihara, K., Takano‐Yamamoto, T., et al. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-006-0716-x · Cited by 74 · see citing works

An electron microscopic study on the presence of proteoglycans in the mineralized matrix of rat and human compact lamellar bone

Sauren, Y. M. H. F., Mieremet, R. H. P., Groot, C. G., & Scherft, J. P. (1992) · The Anatomical Record · doi:10.1002/ar.1092320105 · Cited by 63 · see citing works

Functional organization of the cytoskeleton

Tilney, L. G., & Tilney, M. S. (1986) · Hearing Research · doi:10.1016/0378-5955(86)90077-8 · Cited by 53 · see citing works

Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells.

Duncan, R. L., Kizer, N. L., Barry, E. L., Friedman, P. A., & Hruska, K. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.5.1864 · Cited by 50 · see citing works

Quantitative Analysis of Platelet αvβ3 Binding to Osteopontin Using Laser Tweezers

Игоревич, Л. Р., Vilaire, G., Shuman, H., BENNETT, J. S., & Weisel, J. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304581200 · Cited by 23 · see citing works

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

Biomechanics and Mechanobiology of Trabecular Bone: A Review

Oftadeh, R., Perez‐Viloria, M., Villa‐Camacho, J. C., Vaziri, A., & Nazarian, A. (2014) · Journal of Biomechanical Engineering · doi:10.1115/1.4029176 · Cited by 554 · see citing works

Mechanosensation and transduction in osteocytes

Klein-Nulend, J., Bakker, A. D., Bacabac, R. G., Vatsa, A., & Weinbaum, S. (2013) · Bone · doi:10.1016/j.bone.2012.10.013 · Cited by 528 · see citing works

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies

Fernández, M., Abbah, S. A., McNamara, L. M., Zeugolis, D. I., Pandit, A. S., & Biggs, M. J. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.005 · Cited by 524 · see citing works

Bone remodelling at a glance

Crockett, J. C., Rogers, M. J., Coxon, F. P., Hocking, L. J., & Helfrich, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.063032 · Cited by 503 · see citing works

Molecular mechanosensors in osteocytes

Qin, L., Liu, W., Cao, H., & Xiao, G. (2020) · Bone Research · doi:10.1038/s41413-020-0099-y · Cited by 484 · see citing works

Orthodontic tooth movement: The biology and clinical implications

Li, Y., Jacox, L. A., Little, S. H., & Ko, C. (2018) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2018.01.007 · Cited by 439 · see citing works

Mechanical Signaling for Bone Modeling and Remodeling

Robling, A. G., & Turner, C. H. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i4.50 · Cited by 424 · see citing works

Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone

Chen, J., Liu, C., You, L., & Simmons, C. A. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.016 · Cited by 424 · see citing works

Mechanically induced osteogenic differentiation – the role of RhoA, ROCKII and cytoskeletal dynamics

Arnsdorf, E. J., Tummala, P., Kwon, R. Y., & Jacobs, C. R. (2009) · Journal of Cell Science · doi:10.1242/jcs.036293 · Cited by 396 · see citing works

Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction

Fritton, S. P., & Weinbaum, S. (2008) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.010908.165136 · Cited by 383 · see citing works

On a Path to Unfolding the Biological Mechanisms of Orthodontic Tooth Movement

Krishnan, V., & Davidovitch, Z. (2009) · Journal of Dental Research · doi:10.1177/0022034509338914 · Cited by 360 · see citing works

Mechanical loading and how it affects bone cells: The role of the osteocyte cytoskeleton in maintaining our skeleton

Klein‐Nulend, J., Bacabac, R. G., & Bakker, A. D. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a20 · Cited by 338 · see citing works

Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: Direct evidence for load-induced fluid flow

Price, C., Zhou, X., Li, W., & Wang, L. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.211 · Cited by 279 · see citing works

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

Viola Vogel, B., & Sheetz, M. P. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.002 · Cited by 261 · see citing works

Attachment of Osteocyte Cell Processes to the Bone Matrix

McNamara, L. M., Majeska, R. J., Weinbaum, S., Friedrich, V., & Schaffler, M. B. (2009) · The Anatomical Record · doi:10.1002/ar.20869 · Cited by 212 · see citing works

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

Burra, S., Nicolella, D. P., Francis, W. L., Freitas, C. J., Mueschke, N. J., O’Grady, K. P., & Jiang, J. X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009382107 · Cited by 211 · see citing works

Osteocytic signalling pathways as therapeutic targets for bone fragility

Plotkin, L. I., & Bellido, T. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.71 · Cited by 206 · see citing works

Advances in assessment of bone porosity, permeability and interstitial fluid flow

Cardoso, L., Fritton, S. P., Gailani, G., Benalla, M., & Cowin, S. C. (2012) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2012.10.025 · Cited by 203 · see citing works

Osteocyte apoptosis

Jilka, R. L., Noble, B., & Weinstein, R. S. (2012) · Bone · doi:10.1016/j.bone.2012.11.038 · Cited by 202 · see citing works

Osteocyte Mechanobiology and Pericellular Mechanics

Jacobs, C. R., Temiyasathit, S., & Castillo, A. B. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105302 · Cited by 197 · see citing works

Biomechanics: Cell Research and Applications for the Next Decade

Discher, D. E., Dong, C., Fredberg, J. J., Guilak, F., Ingber, D. E., Janmey, P. A., Kamm, R. D., Schmid‐Schönbein, G. W., & Weinbaum, S. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9661-x · Cited by 192 · see citing works

Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts

Lau, E., Al‐Dujaili, S. A., Günther, A., Liu, D., Wang, L., & You, L. (2010) · Bone · doi:10.1016/j.bone.2010.02.031 · Cited by 190 · see citing works

Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach

Verbruggen, S. W., Vaughan, T. J., & McNamara, L. M. (2013) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-013-0487-y · Cited by 174 · see citing works

Towards quantitative 3D imaging of the osteocyte lacuno-canalicular network

Schneider, P., Meier, M., Wepf, R. A., & Müller, R. (2010) · Bone · doi:10.1016/j.bone.2010.07.026 · Cited by 174 · see citing works

Computer simulation of trabecular remodeling in human proximal femur using large-scale voxel FE models: Approach to understanding Wolff's law

TSUBOTA, K.-I., Suzuki, Y., Yamada, T., Hojo, M., Makinouchi, A., & ADACHI, T. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.02.030 · Cited by 165 · see citing works

Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes

Verbruggen, S. W., Vaughan, T. J., & McNamara, L. M. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0286 · Cited by 159 · see citing works

Mechanotransduction in the renal tubule

Weinbaum, S., Duan, Y., Satlin, L. M., Wang, T., & Weinstein, A. M. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00453.2010 · Cited by 158 · see citing works

Gap junctions and hemichannels in signal transmission, function and development of bone

Batra, N. R., Kar, R., & Jiang, J. X. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.09.018 · Cited by 157 · see citing works

Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis

Klein‐Nulend, J., van Oers, R. F. M., Bakker, A. D., & Bacabac, R. G. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.12.007 · Cited by 153 · see citing works

The small world of osteocytes: connectomics of the lacuno-canalicular network in bone

Kollmannsberger, P., Kerschnitzki, M., Repp, F., Wagermaier, W., Weinkamer, R., & Fratzl, P. (2017) · New Journal of Physics · doi:10.1088/1367-2630/aa764b · Cited by 148 · see citing works

The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture

van Tol, A. F., Schemenz, V., Wagermaier, W., Roschger, A., Razi, H., Vitienes, I., Fratzl, P., Willie, B. M., & Weinkamer, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011504117 · Cited by 148 · see citing works

Serial FIB/SEM imaging for quantitative 3D assessment of the osteocyte lacuno-canalicular network

Schneider, P., Meier, M., Wepf, R. A., & Müller, R. (2011) · Bone · doi:10.1016/j.bone.2011.04.005 · Cited by 143 · see citing works

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require α V β 3 integrin

Thi, M. M., Suadicani, S. O., Schaffler, M. B., Weinbaum, S., & Spray, D. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321210110 · Cited by 141 · see citing works

Calcium response in single osteocytes to locally applied mechanical stimulus: Differences in cell process and cell body

ADACHI, T., Aonuma, Y., TANAKA, M., Hojo, M., Takano‐Yamamoto, T., & Kamioka, H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.04.034 · Cited by 134 · see citing works

The small world of osteocytes: connectomics of the lacuno-canalicular network in bone

Kollmannsberger, P., Kerschnitzki, M., Repp, F., Wagermaier, W., Weinkamer, R., & Fratzl, P. (2017) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-b-000191337 · Cited by 130 · see citing works

Canalicular Network Morphology Is the Major Determinant of the Spatial Distribution of Mass Density in Human Bone Tissue: Evidence by Means of Synchrotron Radiation Phase-Contrast nano-CT

Hesse, B., Varga, P., Langer, M., Pacureanu, A., Schrof, S., Männicke, N., Suhonen, H., Maurer, P., Cloetens, P., Peyrin, F., et al. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2324 · Cited by 128 · see citing works

Alterations in the osteocyte lacunar–canalicular microenvironment due to estrogen deficiency

Sharma, D., Ciani, C., Marin, P. A. R., Levy, J. D., Doty, S. B., & Fritton, S. P. (2012) · Bone · doi:10.1016/j.bone.2012.05.014 · Cited by 125 · see citing works

The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States

Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 127 · see citing works

Predicting cortical bone adaptation to axial loading in the mouse tibia

Pereira, A. F., Javaheri, B., Pitsillides, A. A., & Shefelbine, S. J. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0590 · Cited by 120 · see citing works

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

Lewis, K. J., Frikha-Benayed, D., Louie, J., Stephen, S. J., Spray, D. C., Thi, M. M., Şeref-Ferlengez, Z., Majeska, R. J., Weinbaum, S., & Schaffler, M. B. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707863114 · Cited by 112 · see citing works

The role of osteocytes in bone mechanotransduction

Santos, A., Bakker, A. D., & Klein‐Nulend, J. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0858-5 · Cited by 109 · see citing works

The molecular basis of bone mechanotransduction.

Yavropoulou, M. P., & Yovos, J. G. (2016) · PubMed Central · Cited by 105 · see citing works

β1 Integrins Mediate Mechanosensitive Signaling Pathways in Osteocytes

Litzenberger, J. B., Kim, J., Tummala, P., & Jacobs, C. R. (2010) · Calcified Tissue International · doi:10.1007/s00223-010-9343-6 · Cited by 105 · see citing works

Perlecan-Containing Pericellular Matrix Regulates Solute Transport and Mechanosensing Within the Osteocyte Lacunar-Canalicular System

Wang, B., Lai, X., Price, C., Thompson, W. R., Li, W., Quabili, T. R., Tseng, W., Liu, X. S., Zhang, H., Pan, J. P., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2105 · Cited by 104 · see citing works

Molecular analyses of dinosaur osteocytes support the presence of endogenous molecules

Schweitzer, M. H., Zheng, W., Cleland, T. P., & Bern, M. W. (2012) · Bone · doi:10.1016/j.bone.2012.10.010 · Cited by 104 · see citing works

Synchrotron X-ray phase nano-tomography-based analysis of the lacunar–canalicular network morphology and its relation to the strains experienced by osteocytes in situ as predicted by case-specific finite element analysis

Varga, P., Hesse, B., Langer, M., Schrof, S., Männicke, N., Suhonen, H., Pacureanu, A., Pahr, D. H., Peyrin, F., & Raum, K. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0601-9 · Cited by 101 · see citing works

Osteocyte Shape and Mechanical Loading

van Oers, R. F. M., Wang, H., & Bacabac, R. G. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0256-1 · Cited by 99 · see citing works

Cyclic GMP and Protein Kinase G Control a Src-Containing Mechanosome in Osteoblasts

Rangaswami, H., Schwappacher, R., Marathe, N., Zhuang, S., Casteel, D. E., Haas, B., Chen, Y., Pfeifer, A., Kato, H., Shattil, S. J., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2001423 · Cited by 95 · see citing works

Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model

Jungreuthmayer, C., Jaasma, M. J., Al-Munajjed, A. A., Zanghellini, J., Kelly, D. J., & O’Brien, F. J. (2008) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2008.11.003 · Cited by 95 · see citing works

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model

Kamioka, H., KAMEO, Y., Imai, Y., Bakker, A. D., Bacabac, R. G., Yamada, N., Takaoka, A., Yamashiro, T., ADACHI, T., & Klein‐Nulend, J. (2012) · Integrative Biology · doi:10.1039/c2ib20092a · Cited by 94 · see citing works

Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia

Vaughan, T. J., Mullen, C. A., Verbruggen, S. W., & McNamara, L. M. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0631-3 · Cited by 91 · see citing works

Oscillatory Flow-induced Proliferation of Osteoblast-like Cells Is Mediated by αvβ3 and β1 Integrins through Synergistic Interactions of Focal Adhesion Kinase and Shc with Phosphatidylinositol 3-Kinase and the Akt/mTOR/p70S6K Pathway*

Lee, D.-Y., Li, Y.-S. J., Chang, S.-F., Zhou, J., Ho, H., Chiu, J., & Chien, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010512 · Cited by 93 · see citing works

A Comparative Study of Shear Stresses in Collagen-Glycosaminoglycan and Calcium Phosphate Scaffolds in Bone Tissue-Engineering Bioreactors

Jungreuthmayer, C., Donahue, S. W., Jaasma, M. J., Al-Munajjed, A. A., Zanghellini, J., Kelly, D. J., & O’Brien, F. J. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0204 · Cited by 89 · see citing works

Osteocytes and Estrogen Deficiency

McNamara, L. M. (2021) · Current Osteoporosis Reports · doi:10.1007/s11914-021-00702-x · Cited by 88 · see citing works

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen

Shi, Z., Wang, H., & Tarbell, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015956 · Cited by 88 · see citing works

Integrins in Osteocyte Biology and Mechanotransduction

Geoghegan, I. P., Hoey, D. A., & McNamara, L. M. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00520-2 · Cited by 82 · see citing works

Osteocyte calcium signaling response to bone matrix deformation

ADACHI, T., Aonuma, Y., Ito, S., TANAKA, M., Hojo, M., Takano‐Yamamoto, T., & Kamioka, H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.07.006 · Cited by 81 · see citing works

Solute Transport in the Bone Lacunar-Canalicular System (LCS)

Wang, L. (2018) · Current Osteoporosis Reports · doi:10.1007/s11914-018-0414-3 · Cited by 80 · see citing works

The role of integrin αVβ3 in osteocyte mechanotransduction

Haugh, M. G., Vaughan, T. J., & McNamara, L. M. (2014) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2014.11.001 · Cited by 78 · see citing works

Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels

Riquelme, M. A., Gu, S., Hua, R., & Jiang, J. X. (2021) · Bone Research · doi:10.1038/s41413-020-00126-w · Cited by 77 · see citing works

Mechanically induced autophagy is associated with ATP metabolism and cellular viability in osteocytes in vitro

Zhang, B., Hou, R., Zou, Z., Luo, T., Zhang, Y., Wang, L., & Wang, B. (2017) · Redox Biology · doi:10.1016/j.redox.2017.10.021 · Cited by 76 · see citing works

Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis

Verbruggen, S. W., Garrigle, M. J. M., Haugh, M. G., Voisin, M. C., & McNamara, L. M. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.02.031 · Cited by 73 · see citing works

Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress

ADACHI, T., KAMEO, Y., & Hojo, M. (2010) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2010.0073 · Cited by 72 · see citing works

Potential role for a specialized β₃ integrin‐based structure on osteocyte processes in bone mechanosensation

Cabahug‐Zuckerman, P., Stout, R. F., Majeska, R. J., Thi, M. M., Spray, D. C., Weinbaum, S., & Schaffler, M. B. (2018) · Journal of Orthopaedic Research · doi:10.1002/jor.23792 · Cited by 71 · see citing works

Control of Bone Matrix Properties by Osteocytes

Creecy, A., Damrath, J. G., & Wallace, J. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.578477 · Cited by 68 · see citing works

Biomechanical and biophysical environment of bone from the macroscopic to the pericellular and molecular level

Ren, L. M., Yang, P., Wang, Z., Zhang, J., Ding, C., & Shang, P. (2015) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2015.04.021 · Cited by 69 · see citing works

Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone

Weinkamer, R., Kollmannsberger, P., & Fratzl, P. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00515-z · Cited by 62 · see citing works

The Interaction of Vinculin with Actin

Golji, J., & Mofrad, M. R. K. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002995 · Cited by 60 · see citing works

An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes)

Weinbaum, S., Duan, Y., Thi, M. M., & You, L. (2011) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-011-0179-6 · Cited by 60 · see citing works

The Primary Cilium as a Novel Extracellular Sensor in Bone

Hoey, D. A., Chen, J. C., & Jacobs, C. R. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00075 · Cited by 58 · see citing works

Role for β1 integrins in cortical osteocytes during acute musculoskeletal disuse

Phillips, J. A., Almeida, E. A. C., HILL, E., Aguirre, J. I., Rivera, M. F., NACHBANDI, I., Wronski, T. J., van der Meulen, M. C. H., & Globus, R. K. (2008) · Matrix Biology · doi:10.1016/j.matbio.2008.05.003 · Cited by 58 · see citing works

Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms

Titushkin, I. A., Sun, S., Shin, J. H., & Cho, M. (2010) · BioMed Research International · doi:10.1155/2010/743476 · Cited by 57 · see citing works

Occurrence of substance P in bone repair under different load comparison of straight and angulated fracture in rat tibia

Li, J., Ahmed, M., Bergström, J. P., Ackermann, P. W., Stark, A., & Andris Kreicbergs, A. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21169 · Cited by 59 · see citing works

Osteocyte differentiation and the formation of an interconnected cellular network in vitro

Garrigle, M. J. M., Mullen, C., Haugh, M. G., Voisin, M., & McNamara, L. M. (2016) · European Cells and Materials · doi:10.22203/ecm.v031a21 · Cited by 57 · see citing works

Mechanobiology of bone

Iolascon, G., Resmini, G., & Tarantino, U. (2013) · Aging Clinical and Experimental Research · doi:10.1007/s40520-013-0101-2 · Cited by 56 · see citing works

Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process

Wu, D., Schaffler, M. B., Weinbaum, S., & Spray, D. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310003110 · Cited by 56 · see citing works

High-resolution 3D imaging of osteocytes and computational modelling in mechanobiology: insights on bone development, ageing, health and disease

Goggin, P., Zygalakis, K. C., Oreffo, R. O. C., & Schneider, P. (2016) · European Cells and Materials · doi:10.22203/ecm.v031a18 · Cited by 56 · see citing works

The cytoskeleton and connected elements in bone cell mechano-transduction

Gould, N. R., Torre, O. M., Leser, J. M., & Stains, J. P. (2021) · Bone · doi:10.1016/j.bone.2021.115971 · Cited by 54 · see citing works

Ex vivo real-time observation of Ca2+ signaling in living bone in response to shear stress applied on the bone surface

Ishihara, Y., Sugawara, Y., Kamioka, H., Kawanabe, N., Hayano, S., Balam, T. A., Naruse, K., & Yamashiro, T. (2012) · Bone · doi:10.1016/j.bone.2012.12.002 · Cited by 53 · see citing works

Estrogen deficiency attenuates fluid flow‐induced [Ca 2+ ] i oscillations and mechanoresponsiveness of MLO‐Y4 osteocytes

Deepak, V., Kayastha, P., & McNamara, L. M. (2017) · The FASEB Journal · doi:10.1096/fj.201601280r · Cited by 53 · see citing works

Estrogen deficiency impairs integrin αvβ3-mediated mechanosensation by osteocytes and alters osteoclastogenic paracrine signalling

Geoghegan, I. P., Hoey, D. A., & McNamara, L. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-41095-3 · Cited by 52 · see citing works

Mechanisms of osteocyte stimulation in osteoporosis

Verbruggen, S. W., Vaughan, T. J., & McNamara, L. M. (2016) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.05.004 · Cited by 51 · see citing works

Bone regeneration during distraction osteogenesis

Amir, L. R., Everts, V. E., & Bronckers, A. L. J. J. (2009) · Odontology · doi:10.1007/s10266-009-0101-z · Cited by 50 · see citing works

Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system

Wang, B., Zhou, X., Price, C., Li, W., Pan, J. P., & Wang, L. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1804 · Cited by 50 · see citing works

Bone fracture healing: perspectives according to molecular basis

Ruggieri, I. N. C., Cícero, A. M., Issa, J. P. M., & Feldman, S. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01168-0 · Cited by 50 · see citing works

Coalignment of osteocyte canaliculi and collagen fibers in human osteonal bone

Repp, F., Kollmannsberger, P., Roschger, A., Berzlanovich, A. M., Gruber, G. M., Roschger, P., Wagermaier, W., & Weinkamer, R. (2017) · Journal of Structural Biology · doi:10.1016/j.jsb.2017.07.004 · Cited by 49 · see citing works

Vinculin Activation Is Necessary for Complete Talin Binding

Golji, J., Lam, J., & Mofrad, M. R. K. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.11.024 · Cited by 47 · see citing works

Role of mechanical stress on the function of periodontal ligament cells

Pavasant, P., & Yongchaitrakul, T. (2011) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00374.x · Cited by 46 · see citing works

Integrins, insulin like growth factors, and the skeletal response to load

Bikle, D. D. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0597-z · Cited by 46 · see citing works

Effects of loading frequency on the functional adaptation of trabeculae predicted by bone remodeling simulation

KAMEO, Y., ADACHI, T., & Hojo, M. (2011) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2011.03.008 · Cited by 45 · see citing works

PAST, CURRENT AND FUTURE INTERVENTIONAL ORTHOBIOLOGICS TECHNIQUES AND HOW THEY RELATE TO REGENERATIVE REHABILITATION: A CLINICAL COMMENTARY

Centeno, C. J., & Pastoriza, S. M. (2020) · International Journal of Sports Physical Therapy · doi:10.26603/ijspt20200301 · Cited by 45 · see citing works

In silico bone mechanobiology: modeling a multifaceted biological system

Giorgi, M., Verbruggen, S. W., & Lacroix, D. J. (2016) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1356 · Cited by 44 · see citing works

Tunnels in the rock: Dynamics of osteocyte morphogenesis

Moharrer, Y., & Boerckel, J. D. (2021) · Bone · doi:10.1016/j.bone.2021.116104 · Cited by 43 · see citing works

Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone

Ciani, C., Sharma, D., Doty, S. B., & Fritton, S. P. (2013) · Bone · doi:10.1016/j.bone.2013.11.026 · Cited by 43 · see citing works

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size

Hemmatian, H., Jalali, R., Semeins, C. M., Hogervorst, J. M. A., van Lenthe, H., Klein‐Nulend, J., & Bakker, A. D. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0463-8 · Cited by 43 · see citing works

An investigation of the viscoelastic properties and the actin cytoskeletal structure of triple negative breast cancer cells

Hu, J., Zhou, Y., Obayemi, J. D., Du, J. H., & Soboyejo, W. O. (2018) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2018.05.038 · Cited by 42 · see citing works

Strain amplification and integrin based signaling in osteocytes.

Wang, Y., McNamara, L. M., Schaffler, M. B., & Weinbaum, S. (2008) · PubMed · Cited by 41 · see citing works

Establishing the Basis for Mechanobiology-Based Physical Therapy Protocols to Potentiate Cellular Healing and Tissue Regeneration

Ng, J. L., Kersh, M. E., Kilbreath, S. L., & Tate, M. L. K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00303 · Cited by 40 · see citing works

Fluid pressure response in poroelastic materials subjected to cyclic loading

KAMEO, Y., ADACHI, T., & Hojo, M. (2009) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2009.08.002 · Cited by 37 · see citing works

Strain amplification and integrin based signaling in osteocytes.

Wang, Y., McNamara, L. M., Schaffler, M. B., & Weinbaum, S. (2008) · PubMed · Cited by 41 · see citing works

A model for the role of integrins in flow induced mechanotransduction in osteyocytes

Wang, Y., McNamara, L. M., Schaffler, M. B., & Weinbaum, S. (2007) · IEEE Annual Northeast Bioengineering Conference (NEBEC) · doi:10.1109/nebc.2007.4413269 · Cited by 9 · see citing works

Polarized mechanotransduction in osteocytes: role of αVβ3 integrin on the cell processes (1180.9)

Thi, M., Suadicani, S. O., Schaffler, M. B., Weinbaum, S., & Spray, D. C. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1180.9

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require α V β 3 integrin

Thi, M. M., Suadicani, S. O., Schaffler, M. B., Weinbaum, S., & Spray, D. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321210110 · Cited by 141 · see citing works

Potential role for a specialized β₃ integrin‐based structure on osteocyte processes in bone mechanosensation

Cabahug‐Zuckerman, P., Stout, R. F., Majeska, R. J., Thi, M. M., Spray, D. C., Weinbaum, S., & Schaffler, M. B. (2018) · Journal of Orthopaedic Research · doi:10.1002/jor.23792 · Cited by 71 · see citing works