Cited by 246Smoking Behavior and CessationNeuropeptides and Animal PhysiologyNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

CRF–CRF 1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

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George, Olivier, Ghozland, Sandy, Azar, Marc R., Cottone, Pietro, Zorrilla, Eric P., Parsons, Loren H., O'Dell, Laura E., Richardson, Heather N., Koob, George F.·2007·Proceedings of the National Academy of Sciences

Abstract

Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF 1 receptors. Overactivation of the CRF–CRF 1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.

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  1. JL Fellows, A Trosclair, EK Adams Morb Mort Rep 51, 300–303 (2002).
  2. G Paxinos, C Watson The Rat Brain in Stereotoxic Coordinates (Academic, San Diego, 1997).

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Metadata

Authors
George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., & Koob, G. F.
Affiliations
  • Scripps Research Institute (US)
  • Department of Psychology, University of Texas, El Paso, TX 79968
Venue
Proceedings of the National Academy of Sciences
Published
2007-10-23
Volume
104
Issue
43
Pages
17198-17203
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2097077325
Cited by
245
References
45
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 22 · 2012: 16
FWCI
12.46
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Robert Wood Johnson Foundation
  • Tobacco-Related Disease Research Program (12RT-0099)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
nicotine dependence, nicotine self-administration, nicotine withdrawal, corticotropin-releasing factor, CRF1 receptor, anxiety-like behavior, tobacco dependence, nicotine craving
MeSH terms
CRF Receptor, Type 1, Amygdala, Animals, Anxiety, Behavior, Animal, Corticotropin-Releasing Hormone, Feeding Behavior, Male, Mecamylamine, Nicotine, Self Administration, Substance Withdrawal Syndrome, Behavior, Addictive, Rats, Wistar, Receptors, Corticotropin-Releasing Hormone, Rats

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