The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
CRF–CRF 1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
Open accessAbstract
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF 1 receptors. Overactivation of the CRF–CRF 1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.
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In the citing paper
“Nicotine withdrawal leads to an increase in CRF in the CeA, and blockade of CRF1 receptors diminishes nicotine withdrawalinduced anxiety-like behavior (George et al. 2007).”
From Nicotine Withdrawal (2015) · cites this paper as George et al. 2007
In the citing paper
“CRF levels increase by >500% in the CeA after nicotine withdrawal is precipitated with the nAChR antagonist mecamylamine [158].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [158]
In the citing paper
“Injection of a CRF1 receptor antagonist into the CeA blunts anxiety-like behavior during nicotine withdrawal [158].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [158]
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Citations
Cites
Is there a common molecular pathway for addiction?
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Incubation of cocaine craving after withdrawal
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Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction
Koob, G. F., & Le Moal, M. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1442 · Cited by 963
Self-citationBale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850
Self-citationSynaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674
Self-citationPich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565
Self-citationDaily intake of nicotine during cigarette smoking
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Role of Corticotropin-Releasing Factor in Drug Addiction
Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 474
Self-citationIncubation of cocaine craving after withdrawal: a review of preclinical data
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Cited by
Sorted by citations
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Self-citationChronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Benowitz, N. L. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0809890 · Cited by 1,508
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056
Self-citationPharmacology of nicotine: addiction, smoking-induced disease, and therapeutics
Benowitz, N. L. (2009) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094742 · Cited by 979
Metadata
- Authors
- George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., & Koob, G. F.
- Affiliations
- Scripps Research Institute (US)
- Department of Psychology, University of Texas, El Paso, TX 79968
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-10-23
- Volume
- 104
- Issue
- 43
- Pages
- 17198-17203
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2040467
- OpenAlex
- W2097077325
- Cited by
- 245
- References
- 45
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 17 · 2018: 17 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 16 · 2013: 22 · 2012: 16
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Wood Johnson Foundation
- Tobacco-Related Disease Research Program (12RT-0099)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 26741, P01DK026741)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine dependence, nicotine self-administration, nicotine withdrawal, corticotropin-releasing factor, CRF1 receptor, anxiety-like behavior, tobacco dependence, nicotine craving
- MeSH terms
- CRF Receptor, Type 1, Amygdala, Animals, Anxiety, Behavior, Animal, Corticotropin-Releasing Hormone, Feeding Behavior, Male, Mecamylamine, Nicotine, Self Administration, Substance Withdrawal Syndrome, Behavior, Addictive, Rats, Wistar, Receptors, Corticotropin-Releasing Hormone, Rats
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