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Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)
Open accessAbstract
Glycosaminogycans (GAGs) are involved in numerous vital functions in the human body. Mapping the GAG concentration in vivo is desirable for the diagnosis and monitoring of a number of diseases such as osteoarthritis, which affects millions of individuals. GAG loss in cartilage is typically an initiating event in osteoarthritis. Another widespread pathology related to GAG is intervertebral disk degeneration. Currently existing techniques for GAG monitoring, such as delayed gadolinium-enhanced MRI contrast (dGEMRIC), T 1 ρ , and 23 Na MRI, have some practical limitations. We show that by exploiting the exchangeable protons of GAG one may directly measure the localized GAG concentration in vivo with high sensitivity and therefore obtain a powerful diagnostic MRI method.
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Cited by
Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
van Zijl, P. C. M., Lam, W. W., Xu, J., Knutsson, L., & Stanisz, G. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.045 · Cited by 339
Natural D ‐glucose as a biodegradable MRI contrast agent for detecting cancer
Chan, K. W. Y., McMahon, M. T., Kato, Y., Liu, G., Bulte, J. W. M., Bhujwalla, Z. M., Artemov, D., & van Zijl, P. C. M. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24520 · Cited by 337
Zaiss, M., & Bachert, P. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/22/r221 · Cited by 323
Clinical applications of chemical exchange saturation transfer (CEST) MRI
Jones, K. M., Pollard, A. C., & Pagel, M. D. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25838 · Cited by 287
Metadata
- Authors
- Ling, W., Regatte, R. R., Navon, G., & Jerschow, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-19
- Volume
- 105
- Issue
- 7
- Pages
- 2266-2270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053999722
- Cited by
- 533
- References
- 0
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Ling, W., Regatte, R. R., Navon, G., & Jerschow, A. (2008). Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0707666105
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