The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories
Open accessAbstract
Organization in biological membranes spans many orders of magnitude in length scale, but limited resolution in far-field light microscopy has impeded distinction between numerous biomembrane models. One canonical example of a heterogeneously distributed membrane protein is hemagglutinin (HA) from influenza virus, which is associated with controversial cholesterol-rich lipid rafts. Using fluorescence photoactivation localization microscopy, we are able to image distributions of tens of thousands of HA molecules with subdiffraction resolution (≈40 nm) in live and fixed fibroblasts. HA molecules form irregular clusters on length scales from ≈40 nm up to many micrometers, consistent with results from electron microscopy. In live cells, the dynamics of HA molecules within clusters is observed and quantified to determine an effective diffusion coefficient. The results are interpreted in terms of several established models of biological membranes.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Precise Nanometer Localization Analysis for Individual Fluorescent Probes
Thompson, R. E., Larson, D. R., & Webb, W. W. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75618-x · Cited by 2,320
Cited by
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Super-resolution fluorescence microscopy
Huang, B., Bates, M., & Zhuang, X. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061906.092014 · Cited by 1,657
A guide to super-resolution fluorescence microscopy
Schermelleh, L., Heintzmann, R., & Leonhardt, H. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201002018 · Cited by 1,255
Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
Shroff, H., Galbraith, C. G., Galbraith, J. A., & Betzig, E. (2008) · Nature Methods · doi:10.1038/nmeth.1202 · Cited by 873
Lillemeier, B. F., Mörtelmaier, M. A., Forstner, M. B., Huppa, J. B., Groves, J. T., & Davis, M. M. (2010) · Nature Immunology · doi:10.1038/ni.1832 · Cited by 632
Metadata
- Authors
- Hess, S. T., Gould, T. J., Gudheti, M. V., Maas, S. A., Mills, K. D., & Zimmerberg, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-10-30
- Volume
- 104
- Issue
- 44
- Pages
- 17370-17375
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037916829
- Cited by
- 373
- References
- 2
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Hess, S. T., Gould, T. J., Gudheti, M. V., Maas, S. A., Mills, K. D., & Zimmerberg, J. (2007). Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0708066104
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