Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals
Open accessAbstract
Obesity, a global pandemic that debilitates millions of people and burdens society with tens of billions of dollars in health care costs, is deterred by exercise. Although it is presumed that the more strenuous a physical challenge the more effective it will be in the suppression of adiposity, here it is shown that 15 weeks of brief, daily exposure to high-frequency mechanical signals, induced at a magnitude well below that which would arise during walking, inhibited adipogenesis by 27% in C57BL/6J mice. The mechanical signal also reduced key risk factors in the onset of type II diabetes, nonesterified free fatty acid and triglyceride content in the liver, by 43% and 39%, respectively. Over 9 weeks, these same signals suppressed fat production by 22% in the C3H.B6-6T congenic mouse strain that exhibits accelerated age-related changes in body composition. In an effort to understand the means by which fat production was inhibited, irradiated mice receiving bone marrow transplants from heterozygous GFP+ mice revealed that 6 weeks of these low-magnitude mechanical signals reduced the commitment of mesenchymal stem cell differentiation into adipocytes by 19%, indicating that formation of adipose tissue in these models was deterred by a marked reduction in stem cell adipogenesis. Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways.
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Mechanical stimulation of muscle fibers reduces fat accumulation.
“When muscle fibers are mechanically stimulated, the accumulation of fat is reduced. The mechanical stimulation by itself seems to be counteracting the accumulation of fat (Rubin et al., 2007).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Rubin et al., 2007
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Self-citation
- Authors
- Rubin, C. T., Capilla, E., Luu, Y. K., Busa, B., Crawford, H., Nolan, D. J., Mittal, V., Rosen, C. J., Pessin, J. E., & Judex, S.
- Affiliations
- Stony Brook University (US)
- Cold Spring Harbor Laboratory (US)
- Jackson Laboratory (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-11-06
- Volume
- 104
- Issue
- 45
- Pages
- 17879-17884
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2077057
- OpenAlex
- W2135069791
- Cited by
- 274
- References
- 42
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 3 · 2020: 14 · 2019: 18 · 2018: 9 · 2017: 18 · 2016: 16 · 2015: 26 · 2014: 15 · 2013: 14 · 2012: 21
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Aeronautics and Space Administration (NAG91499)
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK033823, R37DK033823, DK 33823)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-45433, R01AR045433, R01AR043498, AR.43498)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
- Keywords
- adipogenesis, mechanical loading, obesity prevention, type 2 diabetes, free fatty acids, hepatic triglycerides, mesenchymal stem cells, bone marrow transplantation, C57BL/6J mice
- MeSH terms
- Adipose Tissue, Animals, Epididymis, Image Processing, Computer-Assisted, Male, Mice, Inbred C57BL, Obesity, Physical Stimulation, Risk Factors, Vibration, Signal Transduction, Mechanotransduction, Cellular, Adipogenesis, Mice
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