The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
Open accessAbstract
The regulated clearance of mitochondria is a well recognized but poorly understood aspect of cellular homeostasis, and defects in this process have been linked to aging, degenerative diseases, and cancer. Mitochondria are recycled through an autophagy-related process, and reticulocytes, which completely eliminate their mitochondria during maturation, provide a physiological model to study this phenomenon. Here, we show that mitochondrial clearance in reticulocytes requires the BCL2-related protein NIX (BNIP3L). Mitochondrial clearance does not require BAX, BAK, BCL-X L , BIM, or PUMA, indicating that NIX does not function through established proapoptotic pathways. Similarly, NIX is not required for the induction of autophagy during terminal erythroid differentiation. NIX is required for the selective elimination of mitochondria, however, because mitochondrial clearance, in the absence of NIX, is arrested at the stage of mitochondrial incorporation into autophagosomes and autophagosome maturation. These results yield insight into the mechanism of mitochondrial clearance in higher eukaryotes. Furthermore, they show a BAX- and BAK-independent role for a BCL2-related protein in development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331
Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., & Korsmeyer, S. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00127-7 · Cited by 1,677
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1499 · Cited by 874
BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy
Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369
Tal, R., Winter, G., Ecker, N., Klionsky, D. J., & Abeliovich, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m605940200 · Cited by 268
Research works printed but not linked: 36
- 10.1126/science.1059108 · DOI · Paper page
- 10.1016/j.ccr.2006.03.027 · DOI · Paper page
- 10.1126/science.1133289 · DOI
- 10.1073/pnas.95.9.4997 · DOI · Paper page
- 10.1038/35160 · DOI · Paper page
- 10.1016/0092-8674(94)90202-X · DOI · Paper page
- 10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0 · DOI
- 10.1084/jem.186.12.1975 · DOI · Paper page
- 10.1074/jbc.274.1.7 · DOI · Paper page
- 10.1074/jbc.273.20.12415 · DOI
- 10.1038/sj.onc.1202722 · DOI
- 10.1128/MCB.20.15.5454-5468.2000 · DOI · Paper page
- 10.1073/pnas.97.16.9082 · DOI · Paper page
- HM Sowter, PJ Ratcliffe, P Watson, AH Greenberg, AL Harris Cancer Res 61, 6669–6673 (2001).
- 10.1074/jbc.M509056200 · DOI
- 10.1016/j.ccr.2004.10.012 · DOI
- 10.1182/blood-2002-11-3324 · DOI
- 10.1038/nm719 · DOI · Paper page
- 10.1073/pnas.0610666104 · DOI
- 10.1136/jcp.43.8.675 · DOI
- 10.1038/26500 · DOI · Paper page
- 10.1073/pnas.0504783102 · DOI
- 10.1242/dev.127.22.4949 · DOI
- 10.1182/blood-2004-11-4344 · DOI
- 10.1016/j.cell.2005.07.002 · DOI · Paper page
- 10.1038/sj.emboj.7601689 · DOI · Paper page
- 10.1038/sj.cdd.4401765 · DOI · Paper page
- 10.1242/jcs.01131 · DOI · Paper page
- 10.1038/ncb1426 · DOI · Paper page
- 10.1016/j.bbrc.2005.11.044 · DOI
- 10.4161/auto.4034 · DOI
- 10.1182/blood-2002-03-0686 · DOI
- 10.1016/S1534-5807(03)00120-5 · DOI
- 10.1093/nar/25.21.4323 · DOI
- 10.1016/S1535-6108(03)00244-7 · DOI
- 10.1002/jcp.1041210311 · DOI
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationParkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Regulation mechanisms and signaling pathways of autophagy
He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609
Mitochondria: In Sickness and in Health
Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
Metadata
- Authors
- Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., & Ney, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-04
- Volume
- 104
- Issue
- 49
- Pages
- 19500-19505
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968843321
- Cited by
- 936
- References
- 8
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
