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Cited by 936

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Open access
Schweers, Rachel L., Zhang, Ji, Randall, Mindy S., Loyd, Melanie R., Li, Weimin, Dorsey, Frank C., Kundu, Mondira, Opferman, Joseph T., Cleveland, John L., Miller, Jeffery L., Ney, Paul A.·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0708818104
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Abstract

The regulated clearance of mitochondria is a well recognized but poorly understood aspect of cellular homeostasis, and defects in this process have been linked to aging, degenerative diseases, and cancer. Mitochondria are recycled through an autophagy-related process, and reticulocytes, which completely eliminate their mitochondria during maturation, provide a physiological model to study this phenomenon. Here, we show that mitochondrial clearance in reticulocytes requires the BCL2-related protein NIX (BNIP3L). Mitochondrial clearance does not require BAX, BAK, BCL-X L , BIM, or PUMA, indicating that NIX does not function through established proapoptotic pathways. Similarly, NIX is not required for the induction of autophagy during terminal erythroid differentiation. NIX is required for the selective elimination of mitochondria, however, because mitochondrial clearance, in the absence of NIX, is arrested at the stage of mitochondrial incorporation into autophagosomes and autophagosome maturation. These results yield insight into the mechanism of mitochondrial clearance in higher eukaryotes. Furthermore, they show a BAX- and BAK-independent role for a BCL2-related protein in development.

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Show all 8 references

Research works printed but not linked: 36

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Cited by

Metadata

Authors
Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., & Ney, P. A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-12-04
Volume
104
Issue
49
Pages
19500-19505
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0708818104
OpenAlex
W1968843321
Cited by
936
References
8
FWCI
19.68
Type
journal article
Language
en
Open access
green

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