The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The evolution of gene collectives: How natural selection drives chemical innovation
Open accessAbstract
DNA sequencing has become central to the study of evolution. Comparing the sequences of individual genes from a variety of organisms has revolutionized our understanding of how single genes evolve, but the challenge of analyzing polygenic phenotypes has complicated efforts to study how genes evolve when they are part of a group that functions collectively. We suggest that biosynthetic gene clusters from microbes are ideal candidates for the evolutionary study of gene collectives; these selfish genetic elements evolve rapidly, they usually comprise a complete pathway, and they have a phenotype—a small molecule—that is easy to identify and assay. Because these elements are transferred horizontally as well as vertically, they also provide an opportunity to study the effects of horizontal transmission on gene evolution. We discuss known examples to begin addressing two fundamental questions about the evolution of biosynthetic gene clusters: How do they propagate by horizontal transfer? How do they change to create new molecules?
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Cites
Lateral gene transfer and the nature of bacterial innovation
Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
Natural products as sources of new drugs over the period 1981–2002
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When Less Is More: Gene Loss as an Engine of Evolutionary Change
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Microbial Genes in the Human Genome: Lateral Transfer or Gene Loss?
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Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
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Cited by
Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.034 · Cited by 981
Self-citationGenomic basis for natural product biosynthetic diversity in the actinomycetes
Nett, M., Ikeda, H., & Moore, B. S. (2009) · Natural Product Reports · doi:10.1039/b817069j · Cited by 757
The evolution of genome mining in microbes – a review
Ziemert, N., Alanjary, M., & Weber, T. (2016) · Natural Product Reports · doi:10.1039/c6np00025h · Cited by 688
Renaissance in antibacterial discovery from actinomycetes
BALTZ, R. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.04.008 · Cited by 498
Biologically Active Secondary Metabolites from the Fungi
Bills, G. F., & Gloer, J. B. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0009-2016 · Cited by 438
Metadata
- Authors
- Fischbach, M. A., Walsh, C. T., & Clardy, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-25
- Volume
- 105
- Issue
- 12
- Pages
- 4601-4608
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014874550
- Cited by
- 309
- References
- 6
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- green
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