The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
Open accessAbstract
How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans , decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this “FOXO-to-FOXO” signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center.
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Cites
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Self-citationStochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820
Self-citationDAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
Lee, S. S., Kennedy, S., Tolonen, A. C., & Ruvkun, G. (2003) · Science · doi:10.1126/science.1083614 · Cited by 669
Self-citationRegulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
Self-citation
Cited by
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Self-citationRubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Long live FOXO : unraveling the role of FOXO proteins in aging and longevity
Martins, R., Lithgow, G. J., & Link, W. (2016) · Aging Cell · doi:10.1111/acel.12427 · Cited by 720
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Self-citationFox transcription factors: from development to disease
Golson, M. L., & Kaestner, K. H. (2016) · Development · doi:10.1242/dev.112672 · Cited by 406
Metadata
- Authors
- Murphy, C. T., Lee, S.-J., & Kenyon, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-11-27
- Volume
- 104
- Issue
- 48
- Pages
- 19046-19050
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166889104
- Cited by
- 179
- References
- 5
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Murphy, C. T., Lee, S.-J., & Kenyon, C. (2007). Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0709613104
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