The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
High glucose induces adipogenic differentiation of muscle-derived stem cells
Open accessAbstract
Regeneration of mesenchymal tissues depends on a resident stem cell population, that in most cases remains elusive in terms of cellular identity and differentiation signals. We here show that primary cell cultures derived from adipose tissue or skeletal muscle differentiate into adipocytes when cultured in high glucose. High glucose induces ROS production and PKCβ activation. These two events appear crucial steps in this differentiation process that can be directly induced by oxidizing agents and inhibited by PKCβ siRNA silencing. The differentiated adipocytes, when implanted in vivo , form viable and vascularized adipose tissue. Overall, the data highlight a previously uncharacterized differentiation route triggered by high glucose that drives not only resident stem cells of the adipose tissue but also uncommitted precursors present in muscle cells to form adipose depots. This process may represent a feed-forward cycle between the regional increase in adiposity and insulin resistance that plays a key role in the pathogenesis of diabetes mellitus.
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Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086
Human aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Insulin Resistance in Morbid Obesity
Greco, A. V., Mingrone, G., Giancaterini, A., Manco, M., Morroni, M., Cinti, S., Granzotto, M., Vettor, R., Camastra, S., & Ferrannini, E. (2002) · Diabetes · doi:10.2337/diabetes.51.1.144 · Cited by 442
Self-citationGallo, A., Ceolotto, G., Pinton, P., Iori, E., Murphy, E., Rutter, G. A., Rizzuto, R., Semplicini, A., & Avogaro, A. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1123 · Cited by 95
Rosiglitazone modifies the adipogenic potential of human muscle satellite cells
De Coppi, P., Milan, G., Scarda, A., Boldrin, L., Centobene, C., Piccoli, M., Pozzobon, M., Pilon, C., Pagano, C., Gamba, P., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0304-6 · Cited by 81
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Uezumi, A., Fukada, S.-I., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,308
Mechanisms of diabetes mellitus-induced bone fragility
On behalf of the IOF Bone and Diabetes Working Group, Napoli, N., Chandran, M., Pierroz, D. D., Abrahamsen, B., Schwartz, A. V., & Ferrari, S. L. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.153 · Cited by 1,107
Fetal programming of skeletal muscle development in ruminant animals1
Du, M., Tong, J., Zhao, J., Underwood, K. R., Zhu, M., Ford, S. P., & Nathanielsz, P. W. (2010) · Journal of Animal Science · doi:10.2527/jas.2009-2311 · Cited by 553
Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease
Zaplatic, E., Bule, M., Shah, S. Z. A., Uddin, M. S., & Niaz, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.055 · Cited by 293
Frailty, Sarcopenia and Diabetes
Morley, J. E., Malmstrom, T. K., Rodriguez-Mañas, L., & Sinclair, A. J. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.001 · Cited by 277
Metadata
- Authors
- Aguiari, P., Leo, S., Zavan, B., Vindigni, V., Rimessi, A., Bianchi, K., Franzin, C., Cortivo, R., Rossato, M., Vettor, R., Abatangelo, G., Pozzan, T., Pinton, P., & Rizzuto, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-01-29
- Volume
- 105
- Issue
- 4
- Pages
- 1226-1231
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137937538
- Cited by
- 279
- References
- 10
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Aguiari, P., Leo, S., Zavan, B., Vindigni, V., Rimessi, A., Bianchi, K., Franzin, C., Cortivo, R., Rossato, M., Vettor, R., Abatangelo, G., Pozzan, T., Pinton, P., & Rizzuto, R. (2008). High glucose induces adipogenic differentiation of muscle-derived stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711402105
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