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Cited by 274

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus

Open access
Nübel, Ulrich, Roumagnac, Philippe, Feldkamp, Mirjam, Song, Jae-Hoon, Ko, Kwan Soo, Huang, Yhu-Chering, Coombs, Geoffrey, Ip, Margaret, Westh, Henrik, Skov, Robert, Struelens, Marc J., Goering, Richard V., Strommenger, Birgit, Weller, Annette, Witte, Wolfgang, Achtman, Mark·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0804178105
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Abstract

A small number of clonal lineages dominates the global population structure of methicillin-resistant Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable β-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. We investigated the evolutionary history of an MRSA clone (ST5) by mutation discovery at 108 loci (46 kb) within a global collection of 135 isolates. The SNPs that were ascertained define a radial phylogenetic structure within ST5 consisting of at least 5 chains of mutational steps that define geographically associated clades. These clades are not concordant with previously described groupings based on staphylococcal protein A gene ( spa ) typing. By mapping the number of independent imports of the staphylococcal cassette chromosome methicillin-resistance island, we also show that import has occurred on at least 23 occasions within this single sequence type and that the progeny of such recombinant strains usually are distributed locally rather than globally. These results provide strong evidence that geographical spread of MRSA over long distances and across cultural borders is a rare event compared with the frequency with which the staphylococcal cassette chromosome island has been imported.

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Metadata

Authors
Nübel, U., Roumagnac, P., Feldkamp, M., Song, J.-H., Ko, K. S., Huang, Y.-C., Coombs, G., Ip, M., Westh, H., Skov, R., Struelens, M. J., Goering, R. V., Strommenger, B., Weller, A., Witte, W., & Achtman, M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2008-09-16
Volume
105
Issue
37
Pages
14130-14135
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0804178105
OpenAlex
W2005522415
Cited by
274
References
40
FWCI
20.46
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus. https://app.cochat.ai/papers/10.1073/pnas.0804178105
The paper
Nübel, U., Roumagnac, P., Feldkamp, M., Song, J.-H., Ko, K. S., Huang, Y.-C., Coombs, G., Ip, M., Westh, H., Skov, R., Struelens, M. J., Goering, R. V., Strommenger, B., Weller, A., Witte, W., & Achtman, M. (2008). Frequent emergence and limited geographic dispersal of methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0804178105

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.