The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays
Open accessAbstract
Rapid and effective differentiation between normal and cancer cells is an important challenge for the diagnosis and treatment of tumors. Here, we describe an array-based system for identification of normal and cancer cells based on a “chemical nose/tongue” approach that exploits subtle changes in the physicochemical nature of different cell surfaces. Their differential interactions with functionalized nanoparticles are transduced through displacement of a multivalent polymer fluorophore that is quenched when bound to the particle and fluorescent after release. Using this sensing strategy we can rapidly (minutes/seconds) and effectively distinguish ( i ) different cell types; ( ii ) normal, cancerous and metastatic human breast cells; and ( iii ) isogenic normal, cancerous and metastatic murine epithelial cell lines.
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Diverse Applications of Nanomedicine
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Self-citationAnisotropic Gold Nanoparticles: Synthesis, Properties, Applications, and Toxicity
Li, N., Zhao, P., & Astruc, D. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201300441 · Cited by 962
Nanotechnology in cancer diagnosis: progress, challenges and opportunities
Zhang, Y., Li, M., Gao, X., Chen, Y., & Liu, T. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0833-3 · Cited by 510
Inorganic nanoparticles engineered to attack bacteria
Miller, K. P., Wang, L., Benicewicz, B. C., & Decho, A. W. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00041f · Cited by 290
Bai, H., Liu, Z., Zhang, T., Du, J., Zhou, C., He, W., Chau, J. H. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2020) · ACS Nano · doi:10.1021/acsnano.0c03404 · Cited by 89
Metadata
- Authors
- Bajaj, A., Miranda, O. R., Kim, I.-B., Phillips, R. L., Jerry, D. J., Bunz, U. H. F., & Rotello, V. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-07-07
- Volume
- 106
- Issue
- 27
- Pages
- 10912-10916
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2108464046
- Cited by
- 309
- References
- 34
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Bajaj, A., Miranda, O. R., Kim, I.-B., Phillips, R. L., Jerry, D. J., Bunz, U. H. F., & Rotello, V. M. (2009). Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0900975106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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