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Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Open accessAbstract
Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade of Alzheimer's disease, little is known about the induction of Aβ aggregation in vivo. Here we show that induction of cerebral β-amyloidosis can be achieved in many different brain areas of APP23 transgenic mice through the injection of dilute Aβ-containing brain extracts. Once the amyloidogenic process has been exogenously induced, the nature of the induced Aβ-deposition is determined by the brain region of the host. Because these observations are reminiscent of a prion-like mechanism, we then investigated whether cerebral β-amyloidosis also can be induced by peripheral and systemic inoculations or by the intracerebral implantation of stainless steel wires previously coated with minute amounts of Aβ-containing brain extract. Results reveal that oral, intravenous, intraocular, and intranasal inoculations yielded no detectable induction of cerebral β-amyloidosis in APP23 transgenic mice. In contrast, transmission of cerebral β-amyloidosis through the Aβ-contaminated steel wires was demonstrated. Notably, plasma sterilization, but not boiling of the wires before implantation, prevented the induction of β-amyloidosis. Our results suggest that minute amounts of Aβ-containing brain material in direct contact with the CNS can induce cerebral β-amyloidosis, but that systemic cellular mechanisms of prion uptake and transport to the CNS may not apply to Aβ.
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“Experimentally, cerebral β-amyloidosis can be exogenously induced by exposure to dilute brain extracts containing aggregated Aβ seeds.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [52]
In the citing paper
“Experimentally, β-amyloid induction can be triggered in transgenic mice by intracerebrally implanted stainless steel wires coated with minute amounts of brain extract rich in aggregated Aβ52 (Fig 2).”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [52]
Citations
Cites
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Self-citationFolding proteins in fatal ways
Selkoe, D. J. (2003) · Nature · doi:10.1038/nature02264 · Cited by 1,432
A General Model of Prion Strains and Their Pathogenicity
Collinge, J., & Clarke, A. R. (2007) · Science · doi:10.1126/science.1138718 · Cited by 1,075
Legname, G., Baskakov, I. V., Nguyen, H.-O. B., Riesner, D., Cohen, F. E., DeArmond, S. J., & Prusiner, S. B. (2004) · Science · doi:10.1126/science.1100195 · Cited by 1,022
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971
Self-citationAlzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
Selkoe, D. J., & Schenk, D. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 829
Normal host prion protein necessary for scrapie-induced neurotoxicity
Brandner, S., Isenmann, S., Raeber, A. J., Fischer, M., Sailer, A. W., Kobayashi, Y., Marino, S., Weissmann, C., & Aguzzi, A. (1996) · Nature · doi:10.1038/379339a0 · Cited by 813
Self-citationPrusiner, S. B. (1991) · PubMed · Cited by 641
DANGER OF ACCIDENTAL PERSON-TO-PERSON TRANSMISSION OF CREUTZFELDT-JAKOB DISEASE BY SURGERY
Bernoulli, C., Siegfried, J., Baumgartner, G., Regli, F., Rabinowicz, T., Gajdusek, D. C., & Gibbs, C. J. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91958-4 · Cited by 508
Neuron loss in APP transgenic mice
Calhoun, M. E., Wiederhold, K.-H., Abramowski, D., Phinney, A. L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., & Jucker, M. (1998) · Nature · doi:10.1038/27351 · Cited by 502
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Rodin, S., Kozin, S. A., Kechko, O. I., Mitkevich, V. A., & Makarov, A. А. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.011 · Cited by 11
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Aires, V., Ziegler‐Waldkirch, S., Friesen, M., Reichardt, W., Erny, D., Loreth, D., Harborne, A. C., Kretz, O., von Elverfeldt, D., & Meyer‐Luehmann, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.862918 · Cited by 8
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Barron, R. M. (2017) · Prion · doi:10.1080/19336896.2017.1283464 · Cited by 7
Muir, R. T., Callum, J. L., Yu, A., Kapral, M. K., Swartz, R. H., Black, S. E., MacIntosh, B. J., Fergusson, D. A., Kleinman, S. H., Demchuk, A. M., et al. (2024) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2024.150858 · Cited by 6
Kozin, S. A., & Makarov, A. А. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2015115115-9 · Cited by 6
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McDonnell, G., & Comoy, E. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102565-9.00018-2 · Cited by 6
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Gill, A. C., Lane, F. M., Alibhai, J. D., Manson, J. C., & McCutcheon, S. (2012) · CABI Reviews · doi:10.1079/pavsnnr20116055 · Cited by 5
Liberski, P. P., & Ironside, J. W. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-398270-4.00023-9 · Cited by 5
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Chiba, T. (2013) · InTech eBooks · doi:10.5772/55293 · Cited by 5
Bitan, F. R. A. G. (2014) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608058525114020014 · Cited by 4
The effect of Aβ seeding is dependent on the presence of knock-in genes in the AppNL−G−F mice
Lacoursiere, S. G., Safar, J., Westaway, D. A., Mohajerani, M. H., & Sutherland, R. J. (2022) · Frontiers in Dementia · doi:10.3389/frdem.2022.941879 · Cited by 4
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Agnati, L. F., Guidolin, D., Woods, A. S., Ciruela, F., Carone, C., Vallelunga, A., Escuela, D. O. B., Genedani, S., & Fuxé, K. (2013) · Current Protein and Peptide Science · doi:10.2174/1389203711314020006 · Cited by 4
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Metternich, R. E., & Tarzia, G. (2010) · ChemMedChem · doi:10.1002/cmdc.201000266 · Cited by 4
Monitoring Cell-to-cell Transmission of Prion-like Protein Aggregates in Drosophila Melanogaster
Donnelly, K. M., & Pearce, M. M. P. (2018) · Journal of Visualized Experiments · doi:10.3791/56906 · Cited by 5
One or more β-amyloid(s)? New insights into the prion-like nature of Alzheimer's disease
Catania, M., & Fede, G. D. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.07.003 · Cited by 4
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Liu, Q., Song, S., Liu, L., & Hong, W. (2025) · Biomolecules · doi:10.3390/biom15040571 · Cited by 5
Yang, Y., Wang, M., Yang, P., Wang, Z., Huang, L., Xu, J., Wang, W., Yu, M., Bu, L., Fei, J., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00208 · Cited by 3
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Moore, B. D., Levites, Y., Xu, G. M., Hampton, H., Adamo, M. F., Croft, C. L., Futch, H. S., Moran, C., Fromholt, S., Janus, C., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1040944/v1 · Cited by 3
Purro, S. A., Farmer, M., Quarterman, E., Ravey, J., Thomas, D. X., Noble, E., Turnbull, C., Linehan, J. M., Nazari, T., Brandner, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.11.602448 · Cited by 3
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Victoroff, J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.006
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Vazquez‐Sanchez, S., Tilkin, B., Gasset-Rosa, F., Zhang, S., Piol, D., McAlonis‐Downes, M., Artates, J. W., Govea-Perez, N., Verresen, Y., Guo, L. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26019613
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Combes, M. (2018) · theses.fr (ABES) · doi:10.70675/a219ef4dzbca0z4272z8bf2z74080a1976e5 · Cited by 1
Lam, S. (2021) · theses.fr (ABES) · doi:10.70675/60b353ffz56fcz41a2z9e53zf0d9ac078167 · Cited by 1
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Castelot, R. (2024) · theses.fr (ABES) · doi:10.70675/c2a7ce1ez8caaz4593zbb3azae8add8055b5
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Mao, A., Ruiz‐Riquelme, A., Barghash, M. M., Silver, N. R. G., Lau, H. H. C., Stuart, E., Zampar, S., Sehlin, D., Syvänen, S., Pollanen, M. S., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02390-z
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Metadata
- Authors
- Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., & Jucker, M.
- Affiliations
- Hertie Institute for Clinical Brain Research (DE)
- Department of Pathology, Institute for Neuropathology, University Hospital, Zürich, CH-8091 Switzerland;
- Novartis (Switzerland) (CH)
- SMP GmbH, D-72072 Tübingen, Germany;
- University Hospital Zurich (CH)
- Emory University (US)
- German Center for Neurodegenerative Diseases (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-08-04
- Volume
- 106
- Issue
- 31
- Pages
- 12926-12931
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2722323
- OpenAlex
- W1928837524
- Cited by
- 279
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 6 · 2022: 10 · 2021: 15 · 2020: 22 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 21 · 2014: 20 · 2013: 28 · 2012: 17
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- beta-amyloidosis, Alzheimer's disease, amyloid-beta aggregation, APP23 transgenic mice, intracerebral injection, prion-like transmission, plasma sterilization, brain region specificity, amyloid deposition
- MeSH terms
- Amyloidosis, Animals, Brain Diseases, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Amyloid beta-Peptides, Prion Diseases, Mice
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