Aguzzi, Adriano

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

Cole, T. J., Blendy, J. A., Monaghan, A. P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K., & Schütz, G. (1995) · Genes & Development

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 946

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 836

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., et al. (2014) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 773

Experimental autoimmune encephalomyelitis repressed by microglial paralysis

Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., et al. (2005) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 732

p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases

Zatloukal, K., Stumptner, C., Fuchsbichler, A., Heid, H., Schnoelzer, M., Kenner, L., Kleinert, R., Prinz, M., Aguzzi, A., & Denk, H. (2002) · The American Journal of Pathology

Heat shock proteins researchEndoplasmic Reticulum Stress and Disease

Cited by 624

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

Aguzzi, A., & Rajendran, L. (2009) · Neuron

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 473

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R., & Aguzzi, A. (2004) · Nature Medicine

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 449

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

Grathwohl, S. A., Kälin, R. E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S. A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., et al. (2009) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 401

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., Lemos, R. R., Ordoñez-Ugalde, A., Nicolas, G., da Cunha, J. E. G., et al. (2013) · Nature Genetics

Neurological diseases and metabolismNeurological and metabolic disorders

Cited by 324

Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation

Eisele, Y. S., Bolmont, T., Heikenwalder, M., Langer, F., Jacobson, L. H., Yan, Z.-X., Roth, K., Aguzzi, A., Staufenbiel, M., Walker, L. C., et al. (2009) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 279

Prion protein and Aβ‐related synaptic toxicity impairment

Calella, A. M., Farinelli, M., Nuvolone, M., Mirante, O., Moos, R., Falsig, J., Mansuy, I. M., & Aguzzi, A. (2010) · EMBO Molecular Medicine

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 242

Pathogenesis of prion diseases: current status and future outlook

Aguzzi, A., & Heikenwalder, M. (2006) · Nature Reviews Microbiology

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 207

Pericytes regulate vascular immune homeostasis in the CNS

Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 166

A neuroprotective role for microglia in prion diseases

Zhu, C., Herrmann, U. S., Falsig, J., Abakumova, I., Nuvolone, M., Schwarz, P., Frauenknecht, K., Rushing, E. J., & Aguzzi, A. (2016) · Journal of Experimental Medicine

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 134

Microglia in prion diseases

Aguzzi, A., & Zhu, C. (2017) · Journal of Clinical Investigation

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 122

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

Kranich, J., Krautler, N. J., Falsig, J., Ballmer, B., Li, S., Hutter, G., Schwarz, P., Moos, R., Julius, C., Miele, G., et al. (2010) · Journal of Experimental Medicine

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 110

Ablation of Dicer from Murine Schwann Cells Increases Their Proliferation while Blocking Myelination

Bremer, J., O'Connor, T., Tiberi, C., Rehrauer, H., Weis, J., & Aguzzi, A. (2010) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsMicroRNA in disease regulation

Cited by 87

Prion pathogenesis in the absence of Toll-like receptor signalling

Prinz, M., Heikenwalder, M., Schwarz, P., Takeda, K., Akira, S., & Aguzzi, A. (2003) · The EMBO Reports

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 85

Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrPC

Radovanovic, I., Braun, N., Giger, O. T., Mertz, K., Miele, G., Prinz, M., Navarro, B., & Aguzzi, A. (2005) · The Journal of Neuroscience

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 82

Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Scheckel, C., Imeri, M., Schwarz, P., & Aguzzi, A. (2020) · eLife

Prion Diseases and Protein MisfoldingRNA and protein synthesis mechanisms

Cited by 57

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

Zhu, C., Herrmann, U. S., Li, B., Abakumova, I., Moos, R., Schwarz, P., Rushing, E. J., Colonna, M., & Aguzzi, A. (2015) · Neurobiology of Aging

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 44

Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

Nuvolone, M., Sorce, S., Schwarz, P., & Aguzzi, A. (2015) · PLOS ONE

Prion Diseases and Protein MisfoldingInflammasome and immune disorders

Cited by 39

Glial activation in prion diseases is selectively triggered by neuronal PrPSc

Lakkaraju, A. K. K., Sorce, S., Senatore, A., Nuvolone, M., Guo, J., Schwarz, P., Moos, R., Pelczar, P., & Aguzzi, A. (2022) · Brain Pathology

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 34